Results 41 to 50 of about 22,496 (211)
PLoS ONE, 2021 Retinoic acid receptor-related orphan nuclear receptor (ROR) γt is a member of the RORC nuclear hormone receptor family of transcription factors. RORγt functions as a critical regulator of thymopoiesis and immune responses. RORγt is expressed in multiple
Steven A. Saenz +23 more
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Human RORγt+CD34+ Cells Are Lineage-Specified Progenitors of Group 3 RORγt+ Innate Lymphoid Cells [PDF]
, 2014 SummaryGroup 3 innate lymphoid cells (ILC3s) are defined by the expression of the transcription factor RORγt, which is selectively required for their development. The lineage-specified progenitors of ILC3s and their site of development after birth remain
Huntington, N. +37 more
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RORγT agonists as immune modulators in anticancer therapy.
Biochimica et biophysica acta. Reviews on cancer, 2023 RORγT is a transcription factor that directs the development of Th17 lymphocytes and other IL-17-expressing cells (e.g., Tc17 and ILC3 cells). These cells are involved in the body's defense against pathogenic bacteria and fungi, but they also participate
Joanna Pastwińska +4 more
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Reconciling the spectrum of RORγt+ antigen-presenting cells
bioRxiv, 2023 Three recent contemporaneously published papers1–3 showed that antigen-presenting cells (APC) expressing the nuclear receptor RORγt instruct peripheral regulatory T (pTreg) cell differentiation and establish tolerance to the gut microbiota. These studies
Tyler Park +3 more
semanticscholar +1 more source
Regulated Expression of Nuclear Receptor RORγt Confers Distinct Functional Fates to NK Cell Receptor-Expressing RORγt+ Innate Lymphocytes [PDF]
, 2010 SummaryWhether the recently identified innate lymphocyte population coexpressing natural killer cell receptors (NKRs) and the nuclear receptor RORγt is part of the NK or lymphoid tissue inducer (LTi) cell lineage remains unclear.
Christoph Hölscher +32 more
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ACS Omega, 2023 Retinoic acid receptor-related orphan receptor γ-t (RORγt) and GPBAR1, a transmembrane G-protein-coupled receptor for bile acids, are attractive drug targets to develop clinically relevant small modulators as potent therapeutics for autoimmune diseases ...
Bianca Fiorillo +15 more
semanticscholar +1 more source
RORγt-Raftlin1 complex regulates the pathogenicity of Th17 cells and colonic inflammation
Nature Communications, 2023 Th17 cells that produce Interleukin IL-17 are pathogenic in many human diseases, including inflammatory bowel disease, but are, paradoxically, essential for maintaining the integrity of the intestinal barrier in a non-inflammatory state.
Amir Kumar Singh +13 more
semanticscholar +1 more source
rmIL-23 administration induces RORγt proliferation in liver.
, 2022 FACS staining was performed in liver NPCs isolated from mice administered either PBS or recombinant mouse IL-23 (rmIL-23) by IP injections (A-G): Representative FACS gate, IL-23 induced greater frequency of RORγt+Ki67+ T Cells gated from CD3e+CD4-CD8- (A)
Victor Nunez (11025627) +11 more
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Pharmacological inhibition of RORγt suppresses the Th17 pathway and alleviates arthritis in vivo. [PDF]
PLoS ONE, 2017 Retinoic acid receptor-related-orphan-receptor-C (RORγt) is the key transcription factor that is driving the differentiation of IL-17 producing T-helper 17 (Th17) cells that are implicated in the pathology of various autoimmune and inflammatory diseases.
Ulf Guendisch +10 more
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European journal of medicinal chemistry, 2023 The transcription factor retinoic acid receptor-related orphan receptor γt (RORγt) is an attractive drug target for some autoimmune diseases owing to its roles in the differentiation of human T helper 17 (Th17) cells which produce pro-inflammatory ...
Li-Xue Lu, Nan-nan Sun, Yonghui Wang
semanticscholar +1 more source