Results 41 to 50 of about 2,458 (158)

Bile Acids in Autoimmune Liver Disease: Unveiling the Nexus of Inflammation, Inflammatory Cells, and Treatment Strategies

Cells, 2023
As bile acids not solely play an essential role in nutrition absorption, but also in regulating metabolic functions as well as immune response, bile acids and their signaling pathways are increasingly acknowledged as potential therapeutic targets in the ...
Tianhao Zhou, AbdiGhani Ismail, Heather Francis   +2 more
doaj   +1 more source

Identification of cysteinyl-leukotriene-receptor 1 antagonists as ligands for the bile acid receptor GPBAR1

, 2020
The cysteinyl leukotrienes (CysLTs), i.e. LTC4, LTD4 and LTE4, are a family of proinflammatory agents synthesized from the arachidonic acid. In target cells, these lipid mediators bind to the cysteinyl leukotriene receptors (CysLTR), a family of seven ...
Limongelli V., Sepe V., Biagioli M., Zampella A., Fiorucci S., Distrutti E., Di Giorgio C., Bordoni M., Fiorucci C., Carino A., Conflitti P., Marchianò S., Baldoni M., Roselli R.   +13 more
core   +1 more source

Bile Acids Activated Receptors Regulate Innate Immunity

Frontiers in Immunology, 2018
Once known exclusively for their role in nutrients absorption, primary bile acids, chenodeoxycholic and cholic acid, and secondary bile acids, deoxycholic and lithocholic acid, are signaling molecules, generated from cholesterol breakdown by the ...
Stefano Fiorucci, Michele Biagioli, Angela Zampella, Eleonora Distrutti   +3 more
doaj   +1 more source

Hepatokines, bile acids and ketone bodies are novel Hormones regulating energy homeostasis

Frontiers in Endocrinology, 2023
Current views show that an impaired balance partly explains the fat accumulation leading to obesity. Fetal malnutrition and early exposure to endocrine-disrupting compounds also contribute to obesity and impaired insulin secretion and/or sensitivity. The
Gabriella Garruti, Jacek Baj, Angelo Cignarelli, Sebastio Perrini, Francesco Giorgino   +4 more
doaj   +1 more source

Discovery of new dual GPBAR1 /RORγt modulators with promising activity in the treatment of inflammation diseases [PDF]

, 2022
The inflammatory bowel diseases (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), are chronic inflammatory disorders of the intestine.
Claudia Finamore, Stefano Fiorucci, Carmen Festa, Michele Biagioli, Simona De Marino, Valentina Sepe, Bruno Catalanotti, Angela Zampella   +7 more
core  

Beneficial effects of UDCA and norUDCA in a rodent model of steatosis are linked to modulation of GPBAR1/FXR signaling

, 2022
Non-alcoholic steatosis (NAFLD) and steatohepatitis (NASH) are two highly prevalent human disorders for which therapy remains suboptimal. Bile acids play an essential role in regulating liver metabolism, and several bile acids-based therapy are currently
Bellini R., Morretta E., Urbani G., Monti M. C., Biagioli M., Fiorucci S., Distrutti E., Di Giorgio C., Zampella Angela, Marchiano S., Roselli R., Bordoni M.   +11 more
core   +2 more sources

Immunosuppressive effects of circulating bile acids in human endotoxemia and septic shock: patients with liver failure are at risk

Critical Care, 2023
Background Sepsis-induced immunosuppression is a frequent cause of opportunistic infections and death in critically ill patients. A better understanding of the underlying mechanisms is needed to develop targeted therapies.
Julia Leonhardt, Mirrin J. Dorresteijn, Sophie Neugebauer, Diana Mihaylov, Julia Kunze, Ignacio Rubio, Frank-Stephan Hohberger, Silke Leonhardt, Michael Kiehntopf, Klaus Stahl, Christian Bode, Sascha David, Frank A. D. T. G. Wagener, Peter Pickkers, Michael Bauer   +14 more
doaj   +1 more source

Glycoursodeoxycholic acid regulates bile acids level and alters gut microbiota and glycolipid metabolism to attenuate diabetes

Gut Microbes, 2023
Accumulating evidence suggests that the bile acid regulates type 2 diabetes mellitus (T2DM) through gut microbiota-host interactions. However, the mechanisms underlying such interactions have been unclear.
Bingting Chen, Yu Bai, Fenglian Tong, Junlin Yan, Rui Zhang, Yewei Zhong, Huiwen Tan, Xiaoli Ma   +7 more
doaj   +1 more source

The bile acid receptor GPBAR1 regulates the M1/M2 phenotype of intestinal macrophages and activation of gpbar1 rescues mice from murine colitis

, 2017
GPBAR1 (TGR5 or M-BAR) is a G protein-coupled receptor for secondary bile acids that is highly expressed in monocytes/macrophages. In this study, we aimed to determine the role of GPBAR1 in mediating leukocyte trafficking in chemically induced models of ...
Fiorucci, Stefano, Adriana Carino, Paolo Scarpelli, Cipriani, Sabrina, Marchianò, Silvia, Michele Biagioli, Daniele Sorcini, Scarpelli, Paolo, Angela Zampella, Silvia Marchianò, Biagioli, Michele, Sorcini, Daniele, Carino, Adriana, Daniela Francisci, Stefano Fiorucci, ZAMPELLA, ANGELA, Sabrina Cipriani, Silvia Marchian(`(o)), MARCHIANO', SILVIA, Francisci, Daniela   +19 more
core   +1 more source

Translating gut microbiome research into therapies for type 1 diabetes

Experimental Physiology, EarlyView.
Abstract Type 1 diabetes (T1D) is characterised by the loss of functional pancreatic β‐cells, for which lifelong insulin therapy remains the standard of care. Given that the gut microbiome can influence host health and that shifts in gut microbial profiles have been observed in T1D, growing interest has emerged in the role of the gut microbiome in T1D,
Shanti P. Kok, Max Nieuwdorp, Elena Rampanelli   +2 more
wiley   +1 more source