Results 21 to 30 of about 1,660 (124)

Circulating Bile Acids in Liver Failure Activate TGR5 and Induce Monocyte DysfunctionSummary

Cellular and Molecular Gastroenterology and Hepatology, 2021
Background & Aims: Retention of bile acids in the blood is a hallmark of liver failure. Recent studies have shown that increased serum bile acid levels correlate with bacterial infection and increased mortality.
Julia Leonhardt, Raphael S. Haider, Christoph Sponholz, Silke Leonhardt, Julia Drube, Katrin Spengler, Diana Mihaylov, Sophie Neugebauer, Michael Kiehntopf, Nevin A. Lambert, Andreas Kortgen, Tony Bruns, Frank Tacke, Carsten Hoffmann, Michael Bauer, Regine Heller   +15 more
doaj   +1 more source

Identification of Andrographolide as an Agonist of Bile Acid TGR5 Receptor in a Cell Line to Demonstrate the Reduction in Hyperglycemia in Type-1 Diabetic Rats

Pharmaceuticals, 2023
Andrographolide (ADG) is contained in bitter plants, and its effects are widely thought to be associated with taste receptors. The current study used animal studies and cell lines to investigate the role of ADG in diabetic models.
Yingxiao Li, Kai-Chun Cheng, I-Min Liu, Juei-Tang Cheng   +3 more
doaj   +1 more source

TGR5 Expression Is Associated with Changes in the Heart and Urinary Bladder of Rats with Metabolic Syndrome

Life, 2021
Adipose-derived cytokines may contribute to the inflammation that occurs in metabolic syndrome (MetS). The Takeda G protein-coupled receptor (TGR5) regulates energy expenditure and affects the production of pro-inflammatory biomarkers in metabolic ...
Chia-Chen Hsu, Kai-Chun Cheng, Yingxiao Li, Ping-Hao Hsu, Juei-Tang Cheng, Ho-Shan Niu   +5 more
doaj   +1 more source

Activation of TGR5 protects blood brain barrier via the BRCA1/Sirt1 pathway after middle cerebral artery occlusion in rats

Journal of Biomedical Science, 2020
Background The disruption of the blood–brain barrier (BBB) plays a critical event in the pathogenesis of ischemia stroke. TGR5 is recognized as a potential target for the treatment for neurologic disorders.
Hui Liang, Nate Matei, Devin W. McBride, Yang Xu, Jiping Tang, Benyan Luo, John H. Zhang   +6 more
doaj   +1 more source

Identification of miR-26a as a target gene of bile acid receptor GPBAR-1/TGR5.

PLoS ONE, 2015
GPBAR1/TGR5 is a G protein-coupled receptor of bile acids. TGR5 is known to regulate the BA homeostasis and energy metabolism. Recent studies highlight an important role of TGR5 in alleviating obesity and improving glucose regulation, however, the ...
Xiaosong Chen, Haixia Xu, Lili Ding, Guiyu Lou, Yan Liu, Yalan Yao, Liangwan Chen, Wendong Huang, Xianghui Fu   +8 more
doaj   +1 more source

TGR5 Activation Ameliorates Mitochondrial Homeostasis via Regulating the PKCδ/Drp1-HK2 Signaling in Diabetic Retinopathy

Frontiers in Cell and Developmental Biology, 2022
Background: Diabetic retinopathy (DR) is one of the most important microvascular diseases of diabetes. Our previous research demonstrated that bile acid G-protein-coupled membrane receptor (TGR5), a novel cell membrane receptor of bile acid, ameliorates ...
Meng-Yuan Zhang, Lingpeng Zhu, Xinhua Zheng, Tian-Hua Xie, Wenjuan Wang, Jian Zou, Yan Li, Hong-Ying Li, Jiping Cai, Shun Gu, Yong Yao, Yong Yao, Ting-Ting Wei   +12 more
doaj   +1 more source

Bile Acid Network and Vascular Calcification-Associated Diseases: Unraveling the Intricate Connections and Therapeutic Potential

Clinical Interventions in Aging, 2023
Cui Wang,1,* Qing Ma,2,* Xijie Yu1 1Laboratory of Endocrinology & Metabolism/Department of Endocrinology & Metabolism, Rare Disease Center, West China Hospital, Sichuan University, Chengdu, Sichuan Province, 610041, People’s Republic of China ...
Wang C, Ma Q, Yu X
doaj  

TGR5 activation attenuates neuroinflammation via Pellino3 inhibition of caspase-8/NLRP3 after middle cerebral artery occlusion in rats

Journal of Neuroinflammation, 2021
Background Nucleotide-binding oligomerization domain-like receptor pyrin domain-containing protein 3 (NLRP3) plays an important role in mediating inflammatory responses during ischemic stroke.
Hui Liang, Nathanael Matei, Devin W. McBride, Yang Xu, Zhenhua Zhou, Jiping Tang, Benyan Luo, John H. Zhang   +7 more
doaj   +1 more source

Improving glucose and lipids metabolism: drug development based on bile acid related targets

Cell Stress, 2021
Bariatric surgery is one of the most effective treatment options for severe obesity and its comorbidities. However, it is a major surgery that poses several side effects and risks which impede its clinical use.
Hanchen Shen, Lili Ding, Mehdi Baig, Jingyan Tian, Yang Wang, Wendong Huang   +5 more
doaj   +1 more source

Inflammatory-Dependent Bidirectional Effect of Bile Acids on NLRP3 Inflammasome and Its Role in Ameliorating CPT-11-Induced Colitis

Frontiers in Pharmacology, 2022
Irinotecan (CPT-11) in combination with 5-fluorouracil and leucovorin is a first-line chemotherapy regimen for the treatment of colorectal cancer; however, its clinical application is limited by the dose-limiting gastrointestinal toxicity of colitis.
Chuyao Liao, Di Wang, Siyuan Qin, Ying Zhang, Jie Chen, Ruijie Xu, Fengguo Xu, Pei Zhang   +7 more
doaj   +1 more source