Results 1 to 10 of about 3,436,795 (301)

Unlocking therapeutic potential: exploring cross-talk among emerging nuclear receptors to combat metabolic dysfunction in steatotic liver disease

npj Metabolic Health and Disease
Nuclear receptors (NRs) regulate cellular processes and serve as key targets in treating metabolic dysfunction-associated steatotic liver disease (MASLD) and steatohepatitis (MASH).
Milton Boaheng Antwi, Ariann Jennings, Sander Lefere, Dorien Clarisse, Anja Geerts, Lindsey Devisscher, Karolien De Bosscher   +6 more
doaj   +1 more source

A Convenient Laboratory‐Scale Synthesis Route Toward the PPARα Agonist Pemafibrate

ChemistryOpen
Pemafibrate is a potent and selective agonist of peroxisome proliferator‐activated receptor alpha (PPARα). It was designed to improve lipid metabolism with enhanced safety and efficacy compared to traditional fibrates and is clinically approved in Japan ...
Felien Morlion, Dorien Clarisse, Karolien De Bosscher, Matthias D’hooghe   +3 more
doaj   +1 more source

The gene regulatory networks shaping macrophage plasticity and altered function in fibrosis

Frontiers in Immunology
Tissue inflammation and its resolution are fundamental physiological processes that ensure homeostasis and tissue integrity following injury. A precise balance between pro-inflammatory and pro-resolving mechanisms promotes proper tissue repair, whereas ...
Zsuzsanna Kolostyak, Zsuzsanna Kolostyak, Laszlo Nagy, Laszlo Nagy   +3 more
doaj   +1 more source

MT4-MMP deficiency increases patrolling monocyte recruitment to early lesions and accelerates atherosclerosis

Nature Communications, 2018
Matrix metalloproteinases (MMP) are involved in vascular remodeling associated with plaque progression. Little is known about their immune regulatory role in vascular disorders.
Cristina Clemente, Cristina Rius, Laura Alonso-Herranz, Mara Martín-Alonso, Ángela Pollán, Emilio Camafeita, Fernando Martínez, Rubén A. Mota, Vanessa Núñez, Cristina Rodríguez, Motoharu Seiki, José Martínez-González, Vicente Andrés, Mercedes Ricote, Alicia G. Arroyo   +14 more
doaj   +1 more source

Alveolar Bone Density Reduction in Rats Caused by Unilateral Nasal Obstruction

Balkan Medical Journal, 2019
Background: Oral breathing can cause morphological changes in the oral and maxillofacial regions. Aims: To investigate whether oral breathing affected structural changes in bone tissues. Study Design: Animal experimentation.
Xue Wang, Yongge Cao, Zhenhua Liu, Zihan Wang, Xiaoying Chu, Lei Wang, Xuanxuan Hu, Han Zhao, Zhanqiu Diao, Fengting Peng, Hui Ye, Zhensheng Cao   +11 more
doaj   +1 more source

Molecular Image-Based Prediction Models of Nuclear Receptor Agonists and Antagonists Using the DeepSnap-Deep Learning Approach with the Tox21 10K Library

Molecules, 2020
The interaction of nuclear receptors (NRs) with chemical compounds can cause dysregulation of endocrine signaling pathways, leading to adverse health outcomes due to the disruption of natural hormones.
Yasunari Matsuzaka, Yoshihiro Uesawa
doaj   +1 more source

Liver-specific Nr1h4 deletion in mice with human-like bile acid composition causes severe liver injury

Journal of Lipid Research
The farnesoid X receptor, encoded by NR1H4, is crucial for bile acid, lipid, and glucose metabolism. NR1H4 mutations in humans cause a severe liver injury called progressive familial intrahepatic cholestasis 5.
Yusuke Mishima, Kota Tsuruya, Kinuyo Ida, Satsuki Ieda, Yutaka Inagaki, Akira Honda, Tatehiro Kagawa, Akihide Kamiya   +7 more
doaj   +1 more source

Reduced VLDL clearance in Apoe−/−Npc1−/− mice is associated with increased Pcsk9 and Idol expression and decreased hepatic LDL-receptor levels

Journal of Lipid Research, 2010
Niemann-Pick type C1 (NPC1) promotes the transport of LDL receptor (LDL-R)-derived cholesterol from late endosomes/lysosomes to other cellular compartments.
Minako Ishibashi, David Masson, Marit Westerterp, Nan Wang, Scott Sayers, Rong Li, Carrie L. Welch, Alan R. Tall   +7 more
doaj   +1 more source

Liver X receptors are regulators of adipocyte gene expression but not differentiation

Journal of Lipid Research, 2004
The liver X receptors α and β (LXRα and LXRβ) have been shown to play important roles in lipid homeostasis in liver and macrophages, however, their function in adipose tissue is not well defined.
Sarah Hummasti, Bryan A. Laffitte, Michael A. Watson, Cristin Galardi, Lily C. Chao, Lakshman Ramamurthy, John T. Moore, Peter Tontonoz   +7 more
doaj   +1 more source

Computer-Aided Discovery of Small Molecule Inhibitors of Transcriptional Activity of TLX (NR2E1) Nuclear Receptor

Molecules, 2018
Orphan nuclear receptor TLX (NR2E1) plays a critical role in the regulation of neural stem cells (NSC) as well as in the development of NSC-derived brain tumors.
Evgenia Dueva, Kriti Singh, Anastasia Kalyta, Eric LeBlanc, Paul S. Rennie, Artem Cherkasov   +5 more
doaj   +1 more source