Results 11 to 20 of about 1,364,815 (358)

Nuclear receptors in vascular biology [PDF]

Current Atherosclerosis Reports, 2015
Nuclear receptors sense a wide range of steroids and hormones (estrogens, progesterone, androgens, glucocorticoid, and mineralocorticoid), vitamins (A and D), lipid metabolites, carbohydrates, and xenobiotics.
A Chawla, A McCurley, AA Hamers, AL Bookout, B Fisslthaler, BG Hoebel, C McCarthy, C Zhou, CH Lee, CK Glass, CK Huang, CT Lee, D Bishop-Bailey, D Bishop-Bailey, David Bishop-Bailey, DP Edwards, E Gerlach, F Akbiyik, FA Pereira, FL Wynne, FY Ali, G Pascual, I Dussault, I Spoletini, J He, J Qin, J Sonoda, J Xiang, K Spruiell, KE Swales, L Calza, L Li, L Piqueras, LA Moraes, LA Moraes, LJ Jonk, LR You, M Kaushik, M Matic, N Albermann, N Schafer, N Takamoto, Q Qin, R Zhao, S Asgary, S Chakrabarti, S Marino De, S Stein, SA Kliewer, V Zoete, W El-Sankary, WC Lau, X Wang, Y Ma, Y Sui, Y Sui, YW Hu   +56 more
core   +5 more sources

A chimeric virus-based probe unambiguously detects live circulating tumor cells with high specificity and sensitivity

Molecular Therapy: Methods & Clinical Development, 2021
The current methods for detecting circulating tumor cells (CTCs) suffer from several drawbacks. We report a novel method that is based on a chimeric virus probe and can detect CTCs with extremely high specificity and sensitivity. Moreover, it exclusively
Xinping Fu, Lihua Tao, Xiaoliu Zhang
doaj   +1 more source

NUCLEAR RECEPTORS [PDF]

British Journal of Pharmacology, 2007
ALEXANDER, S.P.H., MATHIE, A. & PETERS, J.A. (2007). Guide to Receptors and Channels (GRAC), 2nd edition (2007 revision). Br. J. Pharmacol., 150 (Suppl. 1), S1–S168.
S. P. H. Alexander, A Mathie, J. A. Peters   +2 more
openaire   +3 more sources

Carboxylic Acid Bioisosteres in Medicinal Chemistry: Synthesis and Properties

Journal of Chemistry, 2022
Lead optimization represents the tedious process of fine-tuning lead compounds from biologically active hits to suitable drug candidates for clinical trials.
Kato Bredael, Silke Geurs, Dorien Clarisse, Karolien De Bosscher, Matthias D’hooghe   +4 more
doaj   +1 more source

Comprehensive and systemic optimization for improving the yield of SARS-CoV-2 spike pseudotyped virus

Molecular Therapy: Methods & Clinical Development, 2021
Virus neutralization assay is principally conducted by measuring the ability of the antibodies in patient sera to prevent the infection of susceptible cells by the virus.
Xinping Fu, Lihua Tao, Xiaoliu Zhang
doaj   +1 more source

How the glucocorticoid receptor contributes to platinum-based therapy resistance in solid cancer

Nature Communications, 2021
Synthetic glucocorticoids serve as co-medication against solid malignant tumors. However, glucocorticoid receptor activation may promote unsolicited cancer resistance to chemotherapy.
Dorien Clarisse, Karolien De Bosscher
doaj   +1 more source

The nuclear receptor superfamily [PDF]

Journal of Cell Science, 2003
Nuclear receptors are one of the most abundant classes of transcriptional regulators in animals (metazoans). They regulate diverse functions, such as homeostasis, reproduction, development and metabolism (for a review, see [Laudet and Gronemeyer, 2002][1]).
Robinson-Rechavi, M., Escriva-Garcia, H., Laudet, V.   +2 more
openaire   +3 more sources

Arming HSV-Based Oncolytic Viruses with the Ability to Redirect the Host’s Innate Antiviral Immunity to Attack Tumor Cells

Molecular Therapy: Oncolytics, 2020
One of the major hurdles for cancer immunotherapy is the host’s innate antiviral defense mechanisms. They include innate immune cells, such as natural killer (NK) cells and macrophages, which can be recruited within hours to the site of injection to ...
Xinping Fu, Lihua Tao, Wanfu Wu, Xiaoliu Zhang   +3 more
doaj   +1 more source

Higher nucleoporin-Importinβ affinity at the nuclear basket increases nucleocytoplasmic import. [PDF]

, 2013
Several in vitro studies have shown the presence of an affinity gradient in nuclear pore complex proteins for the import receptor Importinβ, at least partially contributing to nucleocytoplasmic transport, while others have historically argued against the
Azimi, Mohammad, Mofrad, Mohammad
core   +5 more sources

Meta‐analysis and Consolidation of Farnesoid X Receptor Chromatin Immunoprecipitation Sequencing Data Across Different Species and Conditions

Hepatology Communications, 2021
Farnesoid X receptor (FXR) is a nuclear receptor that controls gene regulation of different metabolic pathways and represents an upcoming drug target for various liver diseases.
Emilian Jungwirth, Katrin Panzitt, Hanns‐Ulrich Marschall, Gerhard G. Thallinger, Martin Wagner   +4 more
doaj   +1 more source