Results 41 to 50 of about 3,436,795 (301)
Data Science Journal, 2017 Public transcriptomic assets in the nuclear receptor (NR) signaling field hold considerable collective potential for exposing underappreciated aspects of NR regulation of gene expression.
Scott A. Ochsner +6 more
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Nuclear Receptor Signaling Atlas: Opening Access to the Biology of Nuclear Receptor Signaling Pathways. [PDF]
PLoS ONE, 2015 Signaling pathways involving nuclear receptors (NRs), their ligands and coregulators, regulate tissue-specific transcriptomes in diverse processes, including development, metabolism, reproduction, the immune response and neuronal function, as well as in ...
Lauren B Becnel +10 more
doaj +1 more source
Full-length nuclear receptor allosteric regulation
Journal of Lipid Research, 2023 Nuclear receptors are a superfamily of transcription factors regulated by a wide range of lipids that include phospholipids, fatty acids, heme-based metabolites, and cholesterol-based steroids. Encoded as classic two-domain modular transcription factors,
Woong Jae Choi +2 more
doaj +1 more source
Frontiers in Immunology, 2017 Malaria-associated acute respiratory distress syndrome (MA-ARDS) is an often lethal complication of malaria. Currently, no adequate therapy for this syndrome exists. Although glucocorticoids (GCs) have been used to improve clinical outcome of ARDS, their
Karolina A. Zielińska +9 more
doaj +1 more source
Liver Research, 2019 Estrogen-related receptor gamma (ERRγ) is one of three members of the ERR family and remains an orphan, as there are no known natural ligands. ERRγ is an inducible transcription factor, and its ligand-independent transcriptional activity is regulated by ...
Don-Kyu Kim, Hueng-Sik Choi
doaj +1 more source
Wilson Disease: Update on Pathophysiology and Treatment
Frontiers in Cell and Developmental Biology, 2022 Wilson disease (WD) is a potentially fatal genetic disorder with a broad spectrum of phenotypic presentations. Inactivation of the copper (Cu) transporter ATP7B and Cu overload in tissues, especially in the liver, are established causes of WD.
Som Dev +3 more
doaj +1 more source
Nuclear receptor corepressors [PDF]
Nuclear Receptor Signaling, 2003 The ability of NR LBDs to transfer repression function to a heterologous DNA binding domain, and the cross-squelching of repression by untethered LBDs, has suggested that repression is mediated by interactions with putative cellular corepressor proteins.
openaire +2 more sources
Cell Reports, 2017 Macrophages exert potent effector functions against invading microorganisms but constitute, paradoxically, a preferential niche for many bacterial strains to replicate.
Jonathan Matalonga +23 more
doaj +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen +23 more
wiley +1 more source
Conservation of signaling pathways of xenobiotic-sensing orphan nuclear receptors, chicken xenobiotic receptor, constitutive androstane receptor, and pregnane X receptor, from birds to humans [PDF]
, 2001 Chicken xenobiotic receptor, pregnane X receptor, and constitutive androstane receptor are orphan nuclear receptors that have recently been discovered to regulate drug- and steroid-mediated induction of hepatic cytochromes P450 (CYP).
Stockli, J. +4 more
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