Results 31 to 40 of about 3,436,795 (301)

The Orphan Nuclear Receptor TR4 Is a Vitamin A-activated Nuclear Receptor [PDF]

Journal of Biological Chemistry, 2011
Testicular receptors 2 and 4 (TR2/4) constitute a subgroup of orphan nuclear receptors that play important roles in spermatogenesis, lipid and lipoprotein regulation, and the development of the central nervous system. Currently, little is known about the structural features and the ligand regulation of these receptors.
X Edward, Zhou, Kelly M, Suino-Powell, Yong, Xu, Cee-Wah, Chan, Osamu, Tanabe, Schoen W, Kruse, Ross, Reynolds, James Douglas, Engel, H Eric, Xu   +8 more
openaire   +2 more sources

The dynamics of nuclear receptors and nuclear receptor coregulators in the pathogenesis of endometriosis [PDF]

Human Reproduction Update, 2014
Endometriosis is defined as the colonization and growth of endometrial tissue at anatomic sites outside the uterine cavity. Up to 15% of reproductive-aged women in the USA suffer from painful symptoms of endometriosis, such as infertility, pelvic pain, menstrual cycle abnormalities and increased risk of certain cancers.
Sang Jun, Han, Bert W, O'Malley
openaire   +2 more sources

Regulation of xenobiotic and bile acid metabolism by the nuclear pregnane X receptor

Journal of Lipid Research, 2002
The nuclear pregnane X receptor (PXR; NR1I2) is an integral component of the body's defense mechanism against chemical insult (chemoprotection). PXR is activated by a diverse array of lipophilic chemicals, including xenobiotics and endogenous substances,
Steven A. Kliewer, Timothy M. Willson
doaj   +1 more source

Improved Glucocorticoid Receptor Ligands: Fantastic Beasts, but How to Find Them?

Frontiers in Endocrinology, 2020
Exogenous glucocorticoids are widely used in the clinic for the treatment of inflammatory disorders and hematological cancers. Unfortunately, their use is associated with debilitating side effects, including hyperglycemia, osteoporosis, mood swings, and ...
Laura Van Moortel, Laura Van Moortel, Laura Van Moortel, Kris Gevaert, Kris Gevaert, Karolien De Bosscher, Karolien De Bosscher, Karolien De Bosscher   +7 more
doaj   +1 more source

LXRs, SHP, and FXR in Prostate Cancer: Enemies or Ménage à Quatre With AR? [PDF]

, 2018
Androgens and androgen receptor (AR, NR3C4) clearly play a crucial role in prostate cancer progression. Besides, the link between metabolic disorders and the risk of developing a prostate cancer has been emerging these last years.
Lobaccaro, Jean-Marc, Moschetta, Antonio, Lobaccaro, Jean-Marc A, Cariello, Marica, Ducheix, Simon, Baron, Silvère, Maqdasy, Salwan   +6 more
core   +1 more source

Mechanisms Underlying the Functional Cooperation Between PPARα and GRα to Attenuate Inflammatory Responses

Frontiers in Immunology, 2019
Glucocorticoids (GCs) act via the glucocorticoid receptor (NR3C1, GRα) to combat overshooting responses to infectious stimuli, including lipopolysaccharide (LPS).
Nadia Bougarne, Nadia Bougarne, Nadia Bougarne, Viacheslav Mylka, Viacheslav Mylka, Viacheslav Mylka, Dariusz Ratman, Dariusz Ratman, Dariusz Ratman, Ilse M. Beck, Jonathan Thommis, Jonathan Thommis, Jonathan Thommis, Lode De Cauwer, Lode De Cauwer, Lode De Cauwer, Jan Tavernier, Jan Tavernier, Jan Tavernier, Bart Staels, Claude Libert, Claude Libert, Karolien De Bosscher, Karolien De Bosscher, Karolien De Bosscher   +24 more
doaj   +1 more source

A novel panel of mouse models to evaluate the role of human pregnane X receptor and constitutive androstane receptor in drug response [PDF]

, 2008
The pregnane X receptor (PXR) and the constitutive androstane receptor (CAR) are closely related orphan nuclear hormone receptors that play a critical role as xenobiotic sensors in mammals.
Zevnik, Branko, Rode, Anja, Nicole Faust, Ross, Jillian, C. Roland Wolf, Nico Scheer, Scheer, Nico, Niehaves, Sandra, Sandra Niehaves, Faust, Nicole, Branko Zevnik, Wolf, C. Roland, Jillian Ross, Anja Rode   +13 more
core   +1 more source

Vitamin D3 receptor is highly expressed in Hodgkin's lymphoma [PDF]

, 2012
Background: Hodkin s lymphoma is one of the most frequent lymphoma in western world. Despite an overall good prognosis some patients suffer relapsing tumors which are difficult to cure.
Renné Christoph, Benz Alexander H, Hansmann Martin L, Christoph, Renné, Benz, Alexander, Hansmann, Martin-Leo   +5 more
core   +1 more source

Nuclear Receptor Signaling: A Home for Nuclear Receptor and Coregulator Signaling Research [PDF]

Nuclear Receptor Signaling, 2014
The field of nuclear receptor and coregulator signaling has grown into one of the most active and interdisciplinary in eukaryotic biology. Papers in this field are spread widely across a vast number of journals, which complicates the task of investigators in keeping current with the literature in the field.
McKenna, Neil J., Evans, Ronald M., O’Malley, Bert W.   +2 more
openaire   +2 more sources

Transcriptional Profiling of Monocytes Deficient in Nuclear Orphan Receptors NR4A2 and NR4A3 Reveals Distinct Signalling Roles Related to Antigen Presentation and Viral Response

Frontiers in Immunology, 2021
The nuclear receptor sub-family 4 group A (NR4A) family are early response genes that encode proteins that are activated in several tissues/cells in response to a variety of stressors.
David E. Phelan, David E. Phelan, Masahiko Shigemura, Sarah Aldhafiri, Sarah Aldhafiri, Catarina Mota, Catarina Mota, Thomas J. Hall, Jacob I. Sznajder, Evelyn P. Murphy, Daniel Crean, Daniel Crean, Eoin P. Cummins, Eoin P. Cummins   +13 more
doaj   +1 more source