Results 1 to 10 of about 2,010 (126)

Genome-wide interaction study with body mass index identifies and as genetic modulators of metabolic dysfunction-associated steatotic liver disease [PDF]

Clinical and Molecular Hepatology
Background/Aims Metabolic dysfunction-associated steatotic liver disease (MASLD) may progress to liver inflammation, fibrosis, cirrhosis and hepatocellular carcinoma. So far, genome-wide association studies explain a small fraction of MASLD heritability.
Oveis Jamialahmadi, Endrina Mujica, Lowri Morris, Rosellina Margherita Mancina, Ester Ciociola, Sami F. Qadri, Samantha Maurotti, Francesco Malvestiti, Ruifang Li-Gao, Luisa Ronzoni, Federica Tavaglione, Hannah Maude, Amin Allalou, Anastasia Emmanouilidou, Umberto Vespasiani-Gentilucci, Frits Richard Rosendaal, Hannele Yki-Järvinen, Inês Cebola, Luca Valenti, Marcel den Hoed, Stefano Romeo   +20 more
doaj   +2 more sources

Prox1 directly interacts with LSD1 and recruits the LSD1/NuRD complex to epigenetically co-repress CYP7A1 transcription. [PDF]

PLoS ONE, 2013
Cholesterol 7α-hydroxylase (CYP7A1) catalyzes the first and rate-limiting step in the classical pathway of bile acids synthesis in liver and is crucial for maintaining lipid homeostasis.
Huafang Ouyang, Yi Qin, Yanfeng Liu, Youhua Xie, Jing Liu   +4 more
doaj   +2 more sources

Up to date on cholesterol 7 alpha-hydroxylase (CYP7A1) in bile acid synthesis

Liver Research, 2020
Cholesterol 7 alpha-hydroxylase (CYP7A1, EC1.14) is the first and rate-limiting enzyme in the classic bile acid synthesis pathway. Much progress has been made in understanding the transcriptional regulation of CYP7A1 gene expression and the underlying ...
John Chiang, Jessica M Ferrell
exaly   +3 more sources

Parental betaine supplementation promotes hepatic conversion of cholesterol to bile acids in offspring goslings with epigenetic modulation of CYP7A1 gene [PDF]

Animal Bioscience
Objective Maternal betaine supplementation has been shown to affect offspring metabolism through epigenetic mechanisms in mammals. This study aimed to investigate whether parental betaine supplementation can exert intergenerational effects on hepatic ...
Shuai Ma, Liang Chen, Yan Wang, Lei Wu, Ruqian Zhao   +4 more
doaj   +3 more sources

Atorvastatin Induces FXR and CYP7A1 Activation as a Result of the Sequential Action of PPARγ/PGC-1α/HNF-4α in Hep3B Cells

The Korean Journal of Gastroenterology, 2021
Backgrounds/Aims: PPARγ, farnesoid X receptor (FXR) and CYP7A1 are associated with solubility of bile. This study was performed to understand a mechanism and interactions of statin-induced PPARγ, PGC-1α and HNF-4α related to the statin-induced activation
Jin Lee, Eun Mi Hong, Jang Han Jung, Se Woo Park, Sang Pyo Lee, Dong Hee Koh, Hyun Joo Jang, Sea Hyub Kae   +7 more
doaj   +1 more source

IL‐31 levels correlate with pruritus in patients with cholestatic and metabolic liver diseases and is farnesoid X receptor responsive in NASH

Hepatology, EarlyView., 2022
IL‐31 levels correlate with pruritus in patients with cholestatic and metabolic liver diseases Abstract Background and Aims Pruritus is associated with multiple liver diseases, particularly those with cholestasis, but the mechanism remains incompletely understood.
Jun Xu, Ya Wang, Mina Khoshdeli, Matt Peach, Jen‐Chieh Chuang, Julie Lin, Wen‐Wei Tsai, Sangeetha Mahadevan, Wesley Minto, Lauri Diehl, Ruchi Gupta, Michael Trauner, Keyur Patel, Mazen Noureddin, Kris V. Kowdley, Aliya Gulamhusein, Christopher L. Bowlus, Ryan S. Huss, Robert P. Myers, Chuhan Chung, Andrew N. Billin   +20 more
wiley   +1 more source

Effects of achilline on lipid metabolism gene expression in cell culture

Бюллетень сибирской медицины, 2016
Objective. Evaluation in vitro of the mechanisms of the hypolipidemic effect of sesquiterpene γ-lactone achilline in the hepatoma tissue culture (HTC).Materials and methods.The influence of sesquiterpene γ-lactone achilline and gemfibrozil (comparison ...
A. V. Ratkin, Iu. A. Pfarger, O. A. Kaidash, V. V. Ivanov, M. M. Tsyganov, V. S. Chuchalin, S. M. Adekenov, V. V. Novitsky   +7 more
doaj   +1 more source

Are fucoidan and alginate active substances affecting CYP7A1 and HMG CoA reductase in dyslipidemia condition? [PDF]

Journal of Pharmacy & Pharmacognosy Research
Context: Dyslipidemia, characterized by abnormal plasma lipid levels, is commonly treated with statins, which may induce adverse effects. Fucoidan and alginate, bioactive marine polysaccharides, have emerged as potential natural modulators of lipid ...
Pertiwi Febriana Chandrawati, Loeki Enggar Fitri, Akhmad Sabarudin, Valentina Yurina, M. Izdad Irfani Fanada   +4 more
doaj   +1 more source

TGFβ1, TNFα, and insulin signaling crosstalk in regulation of the rat cholesterol 7α-hydroxylase gene expression*

Journal of Lipid Research, 2008
The TGFβ1/Smad pathway plays a critical role in cholestasis and liver fibrosis. Previous studies show that TGFβ1, TNFα, and insulin inhibit cholesterol 7α-hydroxylase (CYP7A1) gene transcription and bile acid synthesis in human hepatocytes. In this study,
Tiangang Li, Huiyan Ma, John Y.L. Chiang
doaj   +1 more source

A putative role of micro RNA in regulation of cholesterol 7α-hydroxylase expression in human hepatocytes[S]

Journal of Lipid Research, 2010
Cholesterol 7α-hydroxylase (CYP7A1) plays a critical role in regulation of bile acid synthesis in the liver. CYP7A1 mRNAs have very short half-lives, and bile acids destabilize CYP7A1 mRNA via the 3′-untranslated region (3′-UTR).
Kwang-Hoon Song, Tiangang Li, Erika Owsley, John Y.L. Chiang   +3 more
doaj   +1 more source