Results 1 to 10 of about 9,389 (199)

Strategies to inhibit steroid cytochrome P450 enzymes to benefit human health: development of steroid ligands for P450s 17A1, 19A1, and 8B1 to treat cancer and obesity. [PDF]

RSC Med Chem
Ho TM, Yoshimoto FK.
europepmc   +1 more source

Deletion of CH25H and LIPA Genes in Human Abolishes Biosynthesis of 25-Hydroxycholesterol but not of 7α,25-Dihydroxysterols and Enhances Non-enzymatic Cholesterol Oxidation: Metabolic Changes are Partially Reversed by Hematopoietic Stem Cell Transplant^‡

Yutuc E, Ghosh A, Abdel-Khalik J, Goenka A, Asgari MA, Lopez-Castejon G, Beaman GM, Wynn RF, Newman WG, Jones SA, Griffiths WJ, Wang Y.   +11 more
europepmc   +1 more source

A potential role for sterol 27-hydroxylase in atherogenesis

Atherosclerosis, 2001
27-hydroxycholesterol is the product of the mitochondrial cytochrome P450 sterol 27-hydroxylase, a key enzyme in cholesterol metabolism present in most tissues of the body. 27-hydroxycholesterol increases in abundance with progression of human atherosclerotic lesions, therefore the aim of this study was to determine the pattern of sterol 27-hydroxylase
Catherine M Shanahan, Keri L H Carpenter
exaly   +3 more sources

Cafestol, the Cholesterol-Raising Factor in Boiled Coffee, Suppresses Bile Acid Synthesis by Downregulation of Cholesterol 7α-Hydroxylase and Sterol 27-Hydroxylase in Rat Hepatocytes

Arteriosclerosis, Thrombosis, and Vascular Biology, 1997
Consumption of boiled coffee raises serum cholesterol levels in humans. The diterpenes cafestol and kahweol in boiled coffee have been found to be responsible for the increase.
Sabine M Post, Hans M G Princen
exaly   +2 more sources

Transcriptional regulation of the human sterol 27-hydroxylase gene (CYP27) and promoter mapping

Atherosclerosis, 2001
Recent evidence suggests that sterol 27-hydroxylase may play a role in cholesterol homeostasis and affect atherogenesis. The major objective of the study was to map and characterize the sterol 27-hydroxylase (CYP27) promoter region. Here we show that CYP27 gene has a TATA-less promoter and transcription initiates at a cluster of sites.
Alik Honigman, H Rosen, Eran Leitersdorf   +2 more
exaly   +3 more sources

Structural Aspects of Bile Acids Involved in the Regulation of Cholesterol 7alpha-Hydroxylase and Sterol 27-Hydroxylase

FEBS Journal, 1995
Jaap Twisk, Takashi Iida, Adriaan P Ijzerman   +2 more
exaly  

Regulation of sterol 27-hydroxylase and an alternative pathway of bile acid biosynthesis in primary cultures of rat hepatocytes

Journal of Steroid Biochemistry and Molecular Biology, 1996
Philip B Hylemon, Narayan G Avadhani
exaly  

Rabbit liver contains one major sterol 12α-hydroxylase with broad substrate specificity

Lipids and Lipid Metabolism, 1998
Ulla Andersson, Gösta Eggertsen, Ingemar Björkhem   +2 more
exaly