Results 1 to 10 of about 7,409 (117)
Sertraline Treatment Can Mimic Niemann-Pick Type C Biomarker Profile: A Diagnostic Pitfall. [PDF]
Ann Clin Transl NeurolABSTRACT Background Oxysterols (cholestane‐3β,5α,6β‐triol and 7‐ketocholesterol) and N‐palmitoyl‐O‐phosphocholineserine (PPCS) are sensitive biomarkers for Niemann‐Pick disease type C (NPC) screening. However, false‐positive results occur, with a biomarker profile suggestive of NPC despite the absence of pathogenic variants in genes involved in NPC or ...
Makrygianni M +19 more
europepmc +2 more sources
Oxysterol signaling in the central nervous system: cellular mechanisms and implications for neurodegeneration [PDF]
Frontiers in Molecular NeuroscienceOxysterols, oxidized derivatives of cholesterol, are key modulators of central nervous system (CNS) function. Acting as both signaling molecules and cytotoxic mediators, oxysterols can influence glial activity, neuroinflammation and myelination.
Raphael P. Ricci +3 more
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HSD3B1 is an oxysterol 3β-hydroxysteroid dehydrogenase in human placenta
Open Biology, 2023 Most biologically active oxysterols have a 3β-hydroxy-5-ene function in the ring system with an additional site of oxidation at C-7 or on the side-chain.
Alison Dickson +6 more
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Impact of Oxysterols on Cell Death, Proliferation, and Differentiation Induction: Current Status
Cells, 2021 Oxysterols are oxidized derivatives of cholesterol produced by enzymatic activity or non-enzymatic pathways (auto-oxidation). The oxidation processes lead to the synthesis of about 60 different oxysterols.
Fábio Alessandro de Freitas +4 more
doaj +1 more source
Oxysterols in the Immune Response to Bacterial and Viral Infections
Cells, 2022 Oxidized cholesterols, the so-called oxysterols, are widely known to regulate cholesterol homeostasis. However, more recently oxysterols have emerged as important lipid mediators in the response to both bacterial and viral infections.
Cheng Xiang Foo +2 more
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BMC Medicine, 2023 Background Breast cancer is the most commonly diagnosed cancer in women worldwide, and underlying mechanistic pathways associated with breast cancer-specific and non-breast cancer-related deaths are of importance.
Nina Sophia Decker +8 more
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Effects of Oxysterols on Immune Cells and Related Diseases
Cells, 2022 Oxysterols are the products of cholesterol oxidation. They have a wide range of effects on several cells, organs, and systems in the body. Oxysterols also have an influence on the physiology of the immune system, from immune cell maturation and migration
Fábio Alessandro de Freitas +5 more
doaj +1 more source
Simultaneous determination of oxysterols, cholesterol and 25-hydroxy-vitamin D3 in human plasma by LC-UV-MS. [PDF]
PLoS ONE, 2015 Oxysterols are promising biomarkers of neurodegenerative diseases that are linked with cholesterol and vitamin D metabolism. There is an unmet need for methods capable of sensitive, and simultaneous quantitation of multiple oxysterols, vitamin D and ...
Rohini Narayanaswamy +9 more
doaj +1 more source
Frontiers in Nutrition, 2022 Cholesterol is a lipid of high nutritional value that easily undergoes oxidation through enzymatic and non-enzymatic pathways, leading to a wide variety of cholesterol oxidation products (COPs), more commonly named oxysterols.
Federico Canzoneri +5 more
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Sulphatation does not appear to be a protective mechanism to prevent oxysterol accumulation in humans and mice. [PDF]
PLoS ONE, 2013 24S- and 27-hydroxycholesterol (24OHC and 27OHC) are potent regulators of different biochemical systems in vitro and are the major circulating oxysterols.
Jure Acimovic +11 more
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