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Cholesterol metabolism: physiological regulation and diseases
MedCommCholesterol homeostasis is crucial for cellular and systemic function. The disorder of cholesterol metabolism not only accelerates the onset of cardiovascular disease (CVD) but is also the fundamental cause of other ailments.
Jiarui Guo +8 more
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Dysregulated cholesterol metabolism in genodermatoses: implications for systemic disease and therapeutic strategies [PDF]
Frontiers in Cell and Developmental BiologyCholesterol plays a critical role in maintaining normal physiological functions, and it is particularly important in skin tissue. Dysregulation of cholesterol metabolism can lead to a spectrum of skin disorders, including ichthyosis, porokeratosis ...
Zhenzhen Xiao +3 more
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Cholesterol Metabolism in T Cells
Frontiers in Immunology, 2017 Compartmentalization and spatial control of biochemical reactions is the foundation of cell-based life on earth. The lipid bilayer system employed by eukaryote cells not only keeps them separate from the environment but also provides a platform for key ...
Andreas Bietz +5 more
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Genetic connections between neurological disorders and cholesterol metabolism
Journal of Lipid Research, 2010 Cholesterol is an essential component of both the peripheral and central nervous systems of mammals. Over the last decade, evidence has accumulated that disturbances in cholesterol metabolism are associated with the development of various neurological ...
Ingemar Björkhem +2 more
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27-Hydroxylation of oncosterone by CYP27A1 switches its activity from pro-tumor to anti-tumor
Journal of Lipid Research, 2023 Oncosterone (6-oxo-cholestane-3β,5α-diol; OCDO) is an oncometabolite and a tumor promoter on estrogen receptor alpha-positive breast cancer (ER(+) BC) and triple-negative breast cancers (TN BC). OCDO is an oxysterol formed in three steps from cholesterol:
Silia Ayadi +7 more
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Journal of Extracellular Vesicles, 2022 Tumour cells are characterized by having lost their differentiation state. They constitutively secrete small extracellular vesicles (sEV) called exosomes when they come from late endosomes.
Michel Record +14 more
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The role of cholesterol metabolism in tumor therapy, from bench to bed
Frontiers in Pharmacology, 2023 Cholesterol and its metabolites have important biological functions. Cholesterol is able to maintain the physical properties of cell membrane, play an important role in cellular signaling, and cellular cholesterol levels reflect the dynamic balance ...
Wenhao Xia +14 more
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Aberrant Cholesterol Metabolism in Ovarian Cancer: Identification of Novel Therapeutic Targets
Frontiers in Oncology, 2021 Cholesterol is an essential substance in mammalian cells, and cholesterol metabolism plays crucial roles in multiple biological functions. Dysregulated cholesterol metabolism is a metabolic hallmark in several cancers, beyond the Warburg effect ...
Jiangnan He +3 more
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Functional significance of cholesterol metabolism in cancer: from threat to treatment
Experimental and Molecular Medicine, 2023 Cholesterol is an essential structural component of membranes that contributes to membrane integrity and fluidity. Cholesterol homeostasis plays a critical role in the maintenance of cellular activities.
Mingming Xiao +9 more
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Coronavirus Infection and Cholesterol Metabolism
Frontiers in Immunology, 2022 Host cholesterol metabolism remodeling is significantly associated with the spread of human pathogenic coronaviruses, suggesting virus-host relationships could be affected by cholesterol-modifying drugs.
Jun Dai +11 more
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