Results 1 to 10 of about 586,733 (196)

Non-Coding RNAs as Critical Modulators of Cholesterol Metabolism in Cancer [PDF]

Biomedicines
Cholesterol metabolism reprogramming helps tumor cells meet their high energy and biosynthetic needs. Many studies link high cholesterol levels to a higher risk of cancers, such as breast, prostate, and colorectal cancer.
Chunyu Zhang, Zhiwei Miao, Yan Xu, Tongguo Shi   +3 more
doaj   +2 more sources

Cholesterol metabolism: physiological regulation and diseases

MedComm
Cholesterol homeostasis is crucial for cellular and systemic function. The disorder of cholesterol metabolism not only accelerates the onset of cardiovascular disease (CVD) but is also the fundamental cause of other ailments.
Jiarui Guo, Silong Chen, Ying Zhang, Jinxia Liu, Luyang Jiang, Lidan Hu, Ke Yao, Yibo Yu, Xiangjun Chen   +8 more
doaj   +2 more sources

Genetic connections between neurological disorders and cholesterol metabolism

Journal of Lipid Research, 2010
Cholesterol is an essential component of both the peripheral and central nervous systems of mammals. Over the last decade, evidence has accumulated that disturbances in cholesterol metabolism are associated with the development of various neurological ...
Ingemar Björkhem, Valerio Leoni, Steve Meaney   +2 more
doaj   +3 more sources

Hepatic cholesterol metabolism in cholesterol gallstone disease

Journal of Lipid Research, 1991
Hepatic cholesterol metabolism was examined in 27 Swedish patients with cholesterol gallstone disease and in 13 patients free of gallstones operated for roentgenographically suspect polyps in the gallbladder.
E Reihnér, B Angelin, I Björkhem, K Einarsson   +3 more
doaj   +3 more sources

Research progress on cholesterol metabolism and tumor therapy [PDF]

Discover Oncology
Cholesterol and its metabolic derivatives have important biological functions and are crucial in tumor initiation, progression, and treatment. Cholesterol maintains the physical properties of cellular membranes and is pivotal in cell signal transduction.
Zewen Chu, Lei Fang, Yanwei Xiang, Yue Ding   +3 more
doaj   +2 more sources

Microbial impact on cholesterol and bile acid metabolism: current status and future prospects

Journal of Lipid Research, 2019
Recently, the gut microbiota has emerged as a crucial factor that influences cholesterol metabolism. Ever since, significant interest has been shown in investigating these host-microbiome interactions to uncover microbiome-mediated functions on ...
Aicha Kriaa, Mélanie Bourgin, Aline Potiron, Héla Mkaouar, Amin Jablaoui, Philippe Gérard, Emmanuelle Maguin, Moez Rhimi   +7 more
doaj   +3 more sources

The Role of Cholesterol Metabolism and Its Regulation in Tumor Development [PDF]

Cancer Medicine
Background Within the tumor microenvironment, tumor cells undergo metabolic reprogramming of cholesterol due to intrinsic cellular alterations and changes in the extracellular milieu.
Yongmei Wu, Wenqian Song, Min Su, Jing He, Rong Hu, Youbo Zhao   +5 more
doaj   +2 more sources

27-Hydroxylation of oncosterone by CYP27A1 switches its activity from pro-tumor to anti-tumor

Journal of Lipid Research, 2023
Oncosterone (6-oxo-cholestane-3β,5α-diol; OCDO) is an oncometabolite and a tumor promoter on estrogen receptor alpha-positive breast cancer (ER(+) BC) and triple-negative breast cancers (TN BC). OCDO is an oxysterol formed in three steps from cholesterol:
Silia Ayadi, Silvia Friedrichs, Regis Soulès, Laly Pucheu, Dieter Lütjohann, Sandrine Silvente-Poirot, Marc Poirot, Philippe de Medina   +7 more
doaj   +1 more source

Localization of sterols and oxysterols in mouse brain reveals distinct spatial cholesterol metabolism [PDF]

, 2020
Dysregulated cholesterol metabolism is implicated in a number of neurological disorders. Many sterols, including cholesterol and its precursors and metabolites, are biologically active and important for proper brain function. However, spatial cholesterol
Angelini, Roberto, Baumert, Mark, Clench, Malcolm, Griffiths, William J., Howell, Owain W., Mast, Natalia, Newton, Jillian, Pikuleva, Irina, Skibinski, David O.F., Wang, Yuqin, Yutuc, Eylan   +10 more
core   +2 more sources

Targeting the liver X receptor with dendrogenin A differentiates tumour cells to secrete immunogenic exosome‐enriched vesicles

Journal of Extracellular Vesicles, 2022
Tumour cells are characterized by having lost their differentiation state. They constitutively secrete small extracellular vesicles (sEV) called exosomes when they come from late endosomes.
Michel Record, Mehdi Attia, Kevin Carayon, Laly Pucheu, Julio Bunay, Régis Soulès, Silia Ayadi, Bruno Payré, Laure Perrin‐Cocon, Florence Bourgailh, Antonin Lamazière, Vincent Lotteau, Marc Poirot, Sandrine Silvente‐Poirot, Philippe de Medina   +14 more
doaj   +1 more source