HMGCR-Driven Cholesterol Metabolism Promotes Osteoarthritis Progression by Accelerating Synovial Fibroblast Senescence. [PDF]
Adv Sci (Weinh)In the pathological context of osteoarthritis (OA), the phosphorylation of AKT1 at Ser473 enhances its binding to Lys140 of Insig1, which facilitates the formation of AKT1–Insig1 complex. Subsequently, the activation of AKT1 promotes the phosphorylation of Insig1 at Ser189, potentially enhancing the dissociation of Insig1 from sterol regulatory element‑
Zhang X +19 more
europepmc +2 more sources
Reduction of circulating cholesterol and apolipoprotein levels during sepsis [PDF]
, 1999 Sepsis with multiple organ failure is frequently associated with a substantial decrease of cholesterol levels. This decrease of cholesterol is strongly associated with mortality suggesting a direct relation between inflammatory conditions and altered ...
Peter Fraunberger +9 more
core +1 more source
The effect of oligomeric procyanidins on endothelial function and cholesterol homeostasis [PDF]
, 2012 PhDOligomeric procyanidins (OPC) are naturally occurring dietary substances, which studies suggest can protect against cardiovascular disease. To explore this further a double-blind randomised controlled crossover trial, EPICURE (Evaluation of high ...
Rull, Gurvinder Kaur
core +4 more sources
Extracellular vesicles: lipids as key components of their biogenesis and functions
Journal of Lipid Research, 2018 Intercellular communication has been known for decades to involve either direct contact between cells or to operate via circulating molecules, such as cytokines, growth factors, or lipid mediators.
Michel Record +3 more
doaj +1 more source
Progress on cholesterol metabolism and non-alcoholic steatohepatitis [PDF]
Jichu yixue yu linchuang, 2022 Non-alcoholic steatohepatitis (NASH) is a progressive form of non-alcoholic fatty liver disease (NAFLD). Cholesterol is an essential substance for biological process.
LI Xiao-xiao, SHU Xiang-bing, ZHANG Li
doaj +1 more source
Peroxisome Proliferator Activated Receptors and Lipoprotein Metabolism [PDF]
, 2008 Plasma lipoproteins are responsible for carrying triglycerides and cholesterol in the blood and ensuring their delivery to target organs. Regulation of lipoprotein metabolism takes place at numerous levels including via changes in gene transcription.
Kersten, A.H., Sander Kersten
core +1 more source
Dendrogenin A drives LXR to trigger lethal autophagy in cancers
Nature Communications, 2017 Dendrogenin A, cholesterol metabolite, has tumor suppressive properties but the mechanisms are unknown. Here the authors show that Dendrogenin A can induce autophagy-mediated cell death in both melanoma and acute myeloid leukaemia.
Gregory Segala +34 more
doaj +1 more source
Sorting through the extensive and confusing roles of sortilin in metabolic disease
Journal of Lipid Research, 2022 Sortilin is a post-Golgi trafficking receptor homologous to the yeast vacuolar protein sorting receptor 10 (VPS10). The VPS10 motif on sortilin is a 10-bladed β-propeller structure capable of binding more than 50 proteins, covering a wide range of ...
Kelly A. Mitok +2 more
doaj +1 more source
Pregnancy and the Biliary Tract
Canadian Journal of Gastroenterology, 2000 Pregnancy induces many physiological changes, some of which may have pathological results. In population studies, gallstones were found in 6.5% to 8.4% of nulliparous women, and in 18.4% to 19.3% of women with two to three or more pregnancies.
Tuvia Gilat, Fred Konikoff
doaj +1 more source
Biliary cholesterol crystallization characterized by single-crystal cryogenic electron diffraction
Journal of Lipid Research, 2005 Cholesterol crystals are the building blocks of cholesterol gallstones. The exact structure of early-forming crystals is still controversial. We combined cryogenic-temperature transmission electron microscopy with cryogenic-temperature electron ...
Daphne Weihs +6 more
doaj +1 more source