Results 21 to 30 of about 7,256 (187)
Cholesterol metabolism: from lipidomics to immunology
Journal of Lipid Research, 2022 Oxysterols, the oxidized forms of cholesterol or of its precursors, are formed in the first steps of cholesterol metabolism. Oxysterols have interested chemists, biologists, and physicians for many decades, but their exact biological relevance in vivo ...
William J. Griffiths, Yuqin Wang
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The role of oxysterols in control of endothelial stiffness
Journal of Lipid Research, 2012 Endothelial dysfunction is a key step in atherosclerosis development. Our recent studies suggested that oxLDL-induced increase in endothelial stiffness plays a major role in dyslipidemia-induced endothelial dysfunction.
Tzu Pin Shentu +9 more
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Metabolism of oxysterols derived from nonenzymatic oxidation of 7-dehydrocholesterol in cells[S]
Journal of Lipid Research, 2013 Recent studies suggest that 7-dehydrocholesterol (7-DHC)-derived oxysterols play important roles in the pathophysiology of Smith-Lemli-Opitz syndrome (SLOS), a metabolic disorder that is caused by defective 3β-hydroxysterol-Δ7-reductase (DHCR7). Although
Libin Xu +4 more
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Oxysterols Protect Epithelial Cells Against Pore-Forming Toxins
Frontiers in Immunology, 2022 Many species of bacteria produce toxins such as cholesterol-dependent cytolysins that form pores in cell membranes. Membrane pores facilitate infection by releasing nutrients, delivering virulence factors, and causing lytic cell damage - cytolysis ...
Thomas J. R. Ormsby +6 more
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Stem Cell Research & Therapy, 2017 Background Oxysterols, oxygenated by-products of cholesterol biosynthesis, play roles in various physiological and pathological systems. However, the effects of oxysterols on periodontal regeneration are unknown.
Jin-Sun Lee +4 more
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Inhibition of herpes simplex-1 virus replication by 25-hydroxycholesterol and 27-hydroxycholesterol
Redox Biology, 2017 Oxysterols are known pleiotropic molecules whose antiviral action has been recently discovered. Here reported is the activity of a panel of oxysterols against HSV-1 with the identification of a new mechanism of action.
Valeria Cagno +9 more
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Simvastatin reduces circulating oxysterol levels in men with hypercholesterolaemia
Redox Biology, 2018 Oxysterols (OHC) are biologically active cholesterol metabolites circulating in plasma that may be formed enzymatically (e.g. 24S-OHC, 25-OHC and 27-OHC) or by autoxidative mechanisms (e.g. 7-ketocholesterol, 7β-OHC and 25-OHC).
Irundika H.K. Dias +5 more
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Arteriosclerosis, Thrombosis, and Vascular Biology, 2002 Oxysterols are oxygenated derivatives of cholesterol that are intermediates or even end products in cholesterol excretion pathways. Because of their ability to pass cell membranes and the blood-brain barrier at a faster rate than cholesterol itself, they are also important as transport forms of cholesterol.
Ingemar, Björkhem, Ulf, Diczfalusy
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Accumulation of oxysterols in the erythrocytes of COVID-19 patients as a biomarker for case severity
Respiratory Research, 2023 Background Due to the high risk of COVID-19 patients developing thrombosis in the circulating blood, atherosclerosis, and myocardial infarction, it is necessary to study the lipidome of erythrocytes.
Alaa Khedr +5 more
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Biochemistry and Biophysics Reports, 2019 Oxysterols are 27-carbon oxidation products of cholesterol metabolism. Oxysterols possess several biological actions, including the promotion of cell death. Here, we examined the ability of 7-ketocholesterol (7-KC), cholestane-3β-5α-6β-triol (triol), and
Debora Levy +7 more
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