25-Hydroxycholesterol Effect on Membrane Structure and Mechanical Properties [PDF]
International Journal of Molecular Sciences, 2021 Cholesterol is responsible for the plasticity of plasma membranes and is involved in physiological and pathophysiological responses. Cholesterol homeostasis is regulated by oxysterols, such as 25-hydroxycholesterol. The presence of 25-hydroxycholesterol at the membrane level has been shown to interfere with several viruses’ entry into their target ...
Nuno C. Santos +2 more
exaly +9 more sources
Cholesterol Metabolites 25-Hydroxycholesterol and 25-Hydroxycholesterol 3-Sulfate Are Potent Paired Regulators: From Discovery to Clinical Usage [PDF]
Metabolites, 2020 Oxysterols have long been believed to be ligands of nuclear receptors such as liver × receptor (LXR), and they play an important role in lipid homeostasis and in the immune system, where they are involved in both transcriptional and posttranscriptional ...
Yaping Wang, Xiaobo Li, Shunlin Ren
doaj +6 more sources
25-Hydroxycholesterol in health and diseases [PDF]
Journal of Lipid ResearchCholesterol is an essential structural component of all membranes of mammalian cells where it plays a fundamental role not only in cellular architecture, but also, for example, in signaling pathway transduction, endocytosis process, receptor functioning ...
Cindy Nguyen +4 more
doaj +6 more sources
25-hydroxycholesterol: an integrator of antiviral ability and signaling [PDF]
Frontiers in Immunology, 2023 Cholesterol, as an important component in mammalian cells, is efficient for viral entry, replication, and assembly. Oxysterols especially hydroxylated cholesterols are recognized as novel regulators of the innate immune response. The antiviral ability of
Jialu Zhang +7 more
doaj +4 more sources
The Oxysterol 25-Hydroxycholesterol Inhibits Replication of Murine Norovirus [PDF]
Viruses, 2019 Cholesterol, an essential component of mammalian cells, is also an important factor in the replicative-cycles of several human and animal viruses.
Ghada T. Shawli +3 more
doaj +7 more sources
Inhibition of Marek’s Disease Virus Replication and Spread by 25-hydroxycholesterol and 27-hydroxycholesterol In Vitro [PDF]
Viruses, 2023 Marek’s disease virus (MDV) causes a deadly lymphoproliferative disease in chickens, resulting in huge economic losses in the poultry industry. It has been suggested that MDV suppresses the induction of type I interferons and thus escapes immune control.
Nitin Kamble +6 more
doaj +3 more sources
25-Hydroxycholesterol as a Signaling Molecule of the Nervous System. [PDF]
Biochemistry (Mosc), 2022 Cholesterol is an essential component of plasma membrane and precursor of biological active compounds, including hydroxycholesterols (HCs). HCs regulate cellular homeostasis of cholesterol; they can pass across the membrane and vascular barriers and act distantly as para- and endocrine agents. A small amount of 25-hydroxycholesterol (25-HC) is produced
Odnoshivkina UG +2 more
europepmc +3 more sources
Increased 25-hydroxycholesterol as an indicator for patients with vestibular neuritis. [PDF]
Front NeurolBackgroundVestibular neuritis (VN) is one of the most common diseases in vestibular vertigo. 25-hydroxycholesterol (25-HC) was correlated to neuroinflammation, however, whether the level of serum 25-HC could be used to diagnose the VN occurrence remains unclear.MethodsThe enrolled patients were divided into VN and healthy control groups.
Song X, Liang J, Tian C.
europepmc +4 more sources
Cholesterol 25-hydroxylase suppresses avian reovirus replication by its enzymatic product 25-hydroxycholesterol [PDF]
Frontiers in Microbiology, 2023 Avian reovirus (ARV) causing viral arthritis/tenosynovitis and viral enteritis in domestic fowl has significantly threatened on the poultry industry worldwide. ARV is a non-enveloped fusogenic virus that belongs to the Reoviridae family.
Yuyang Wang +9 more
doaj +2 more sources
25-Hydroxycholesterol exacerbates vascular leak during acute lung injury [PDF]
JCI Insight, 2023 Cholesterol-25-hydroxylase (CH25H), the biosynthetic enzyme for 25-hydroxycholesterol (25HC), is most highly expressed in the lung, but its role in lung biology is poorly defined.
Jennifer H. Madenspacher +14 more
doaj +2 more sources