25-Hydroxycholesterol in health and diseases [PDF]
Journal of Lipid ResearchCholesterol is an essential structural component of all membranes of mammalian cells where it plays a fundamental role not only in cellular architecture, but also, for example, in signaling pathway transduction, endocytosis process, receptor functioning ...
Cindy Nguyen +4 more
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Cholesterol Metabolites 25-Hydroxycholesterol and 25-Hydroxycholesterol 3-Sulfate Are Potent Paired Regulators: From Discovery to Clinical Usage [PDF]
Metabolites, 2020 Oxysterols have long been believed to be ligands of nuclear receptors such as liver × receptor (LXR), and they play an important role in lipid homeostasis and in the immune system, where they are involved in both transcriptional and posttranscriptional ...
Yaping Wang, Xiaobo Li, Shunlin Ren
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Inhibition of Marek’s Disease Virus Replication and Spread by 25-hydroxycholesterol and 27-hydroxycholesterol In Vitro [PDF]
Viruses, 2023 Marek’s disease virus (MDV) causes a deadly lymphoproliferative disease in chickens, resulting in huge economic losses in the poultry industry. It has been suggested that MDV suppresses the induction of type I interferons and thus escapes immune control.
Nitin Kamble +6 more
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25-hydroxycholesterol: an integrator of antiviral ability and signaling [PDF]
Frontiers in Immunology, 2023 Cholesterol, as an important component in mammalian cells, is efficient for viral entry, replication, and assembly. Oxysterols especially hydroxylated cholesterols are recognized as novel regulators of the innate immune response. The antiviral ability of
Jialu Zhang +7 more
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Cholesterol 25-hydroxylase suppresses avian reovirus replication by its enzymatic product 25-hydroxycholesterol [PDF]
Frontiers in Microbiology, 2023 Avian reovirus (ARV) causing viral arthritis/tenosynovitis and viral enteritis in domestic fowl has significantly threatened on the poultry industry worldwide. ARV is a non-enveloped fusogenic virus that belongs to the Reoviridae family.
Yuyang Wang +9 more
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25-Hydroxycholesterol exacerbates vascular leak during acute lung injury [PDF]
JCI Insight, 2023 Cholesterol-25-hydroxylase (CH25H), the biosynthetic enzyme for 25-hydroxycholesterol (25HC), is most highly expressed in the lung, but its role in lung biology is poorly defined.
Jennifer H. Madenspacher +14 more
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Redox Biology, 2020 There is an urgent need to identify antivirals against the coronavirus SARS-CoV-2 in the current COVID-19 pandemic and to contain future similar emergencies early on.
Alessandro Marcello +2 more
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25-Hydroxycholesterol Effect on Membrane Structure and Mechanical Properties [PDF]
International Journal of Molecular Sciences, 2021 Marco M Domingues +2 more
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The cholesterol metabolite 25-hydroxycholesterol restrains the transcriptional regulator SREBP2 and limits intestinal IgA plasma cell differentiation [PDF]
Immunity, 2021 Bruno C Trindade +2 more
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Frontiers in Nutrition, 2022 Cholesterol is a lipid of high nutritional value that easily undergoes oxidation through enzymatic and non-enzymatic pathways, leading to a wide variety of cholesterol oxidation products (COPs), more commonly named oxysterols.
Federico Canzoneri +5 more
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