Results 1 to 10 of about 6,185 (138)
Membrane properties of hydroxycholesterols related to the brain cholesterol metabolism [PDF]
Beilstein Journal of Organic Chemistry, 2017 Compared to cholesterol, hydroxycholesterols contain an additional hydroxy group in the alkyl chain and are able to efficiently cross the brain–blood barrier. Therefore, they are responsible for the sterol transfer between brain and circulation.
Holger Scheidt, Daniel Huster
exaly +5 more sources
Cells, 2021 Ambient temperature is an important determinant of both the alternative bile acid synthesis pathway controlled by oxysterol 7-α hydroxylase (CYP7B1) and the progression of metabolic-associated fatty liver disease (MAFLD).
Ioannis Evangelakos +9 more
doaj +3 more sources
Oxysterols protect bovine endometrial cells against pore-forming toxins from pathogenic bacteria. [PDF]
FASEB J, 2021 Many species of pathogenic bacteria secrete toxins that form pores in mammalian cell membranes. These membrane pores enable the delivery of virulence factors into cells, result in the leakage of molecules that bacteria can use as nutrients, and ...
Ormsby TJR +8 more
europepmc +4 more sources
Analysis of bioactive oxysterols in newborn mouse brain by LC/MS
Journal of Lipid Research, 2012 Unesterified cholesterol is a major component of plasma membranes. In the brain of the adult, it is mostly found in myelin sheaths, where it plays a major architectural role.
Anna Meljon +9 more
doaj +3 more sources
Elevated hydroxycholesterols in Norwegian patients with hereditary spastic paraplegia SPG5
Journal of the Neurological Sciences, 2020 Spastic paraplegia type 5 (SPG5/HSP-CYP7B1) is an autosomal recessive hereditary spastic paraplegia (HSP) caused by biallelic variants in the CYP7B1 gene, resulting in dysfunction of the enzyme oxysterol-7-α-hydroxylase.
Foudil LAMARI +2 more
exaly +2 more sources
Hydroxycholesterol substitution in ionizable lipid nanoparticles for mRNA delivery to T cells. [PDF]
J Control Release, 2022 Delivery of nucleic acids, such as mRNA, to immune cells has become a major focus in the past decade with ionizable lipid nanoparticles (LNPs) emerging as a clinically-validated delivery platform. LNPs—typically composed of ionizable lipids, cholesterol,
Patel SK +9 more
europepmc +2 more sources
Pharmacokinetic profiling of imatinib in relation to CYP3A4 activity in leukaemia patients. [PDF]
Br J Clin PharmacolAim Imatinib pharmacokinetics exhibit large interindividual variability because of differences in CYP3A4 activity—the main imatinib‐metabolizing enzyme. While therapeutic drug monitoring is effective, it requires steady‐state conditions and frequent sampling.
Rasmussen ASB +14 more
europepmc +2 more sources
Application of Virtual Twin PBPK Models in Individuals with Obesity via CYP3A4 Phenotyping Using Endogenous Biomarker Data. [PDF]
Clin Pharmacol TherPlasma 4β‐hydroxycholesterol (4β‐OHC) normalized for the levels of its parent cholesterol (4β‐OHC/C) is an endogenous biomarker for hepatic CYP3A4. This study evaluated CYP3A4 activity longitudinally in individuals while their obesity status was changing. 4β‐OHC/C was measured pre‐surgery (n = 54) and 2 years after Roux‐en‐Y gastric bypass (n = 30) and
Izat N +6 more
europepmc +2 more sources
Journal of Lipid Research, 2014 Alterations of cholesterol metabolism are responsible for vasospastic angina and atherosclerosis. To comprehensively evaluate cholesterol metabolism, 18 sterols, including cholesterol, 6 cholesteryl esters (CEs), 3 cholesterol precursors, and 8 ...
Hyun-Hwa Son +5 more
doaj +2 more sources
Journal of Lipid Research, 2000 We used an automated Langmuir-Pockels surface balance to characterize the air–water interfacial properties of cholesterol (CH) and its derivatives with hydrophilic OH and F substitutions at isologous sites on the sterol body or side chain.
John M. Kauffman +2 more
exaly +3 more sources