Results 1 to 10 of about 877 (100)
Inhibition of Marek’s Disease Virus Replication and Spread by 25-hydroxycholesterol and 27-hydroxycholesterol In Vitro [PDF]
Viruses, 2023 Marek’s disease virus (MDV) causes a deadly lymphoproliferative disease in chickens, resulting in huge economic losses in the poultry industry. It has been suggested that MDV suppresses the induction of type I interferons and thus escapes immune control.
Nitin Kamble +6 more
doaj +2 more sources
Liver X Receptor α (LXRα) Regulates 5β-Reductase (AKR1D1) Expression in Avian Embryos: Implications for Yolk Steroid Metabolism. [PDF]
J Exp Zool A Ecol Integr PhysiolABSTRACT Steroid‐mediated maternal effects are well‐studied as a source of phenotypic variation. In bird eggs, the yolk contains various steroids that can influence embryonic development. However, one complicating factor in understanding how yolk steroids affect development is that the embryo metabolizes yolk steroids to regulate exposure.
Paitz RT +4 more
europepmc +2 more sources
Membrane properties of hydroxycholesterols related to the brain cholesterol metabolism
Beilstein Journal of Organic Chemistry, 2017 Compared to cholesterol, hydroxycholesterols contain an additional hydroxy group in the alkyl chain and are able to efficiently cross the brain–blood barrier. Therefore, they are responsible for the sterol transfer between brain and circulation.
Ivan Haralampiev, , Daniel Huster
exaly +2 more sources
Journal of Lipid Research, 2000 We used an automated Langmuir-Pockels surface balance to characterize the air–water interfacial properties of cholesterol (CH) and its derivatives with hydrophilic OH and F substitutions at isologous sites on the sterol body or side chain.
Martin C Carey
exaly +3 more sources
Advanced Biomedical Research, 2023 Background: Elevated brain cholesterol increases the risk of Alzheimer's disease. Production of 24-hydroxycholesterol (24s-OHC) by neurons prevents cholesterol accumulation in the brain. In this study, we investigated the effect of 24s-OHC on the HMG-COA
Zahra Nazeri +5 more
doaj +1 more source
Cells, 2021 Ambient temperature is an important determinant of both the alternative bile acid synthesis pathway controlled by oxysterol 7-α hydroxylase (CYP7B1) and the progression of metabolic-associated fatty liver disease (MAFLD).
Ioannis Evangelakos +9 more
doaj +1 more source
Hydroxycholesterol Levels in the Serum and Cerebrospinal Fluid of Patients with Neuromyelitis Optica Revealed by LC-Ag+CIS/MS/MS and LC-ESI/MS/MS with Picolinic Derivatization: Increased Levels and Association with Disability during Acute Attack. [PDF]
PLoS ONE, 2016 Neuromyelitis optica (NMO) is an inflammatory demyelinating disease of the central nervous system (CNS). Hydroxycholesterols (OHCs), metabolites of CNS cholesterol, are involved in diverse cellular responses to inflammation and demyelination, and may ...
Eunju Cha +6 more
doaj +1 more source
Analysis of bioactive oxysterols in newborn mouse brain by LC/MS
Journal of Lipid Research, 2012 Unesterified cholesterol is a major component of plasma membranes. In the brain of the adult, it is mostly found in myelin sheaths, where it plays a major architectural role.
Anna Meljon +9 more
doaj +1 more source
Journal of Lipid Research, 2014 Alterations of cholesterol metabolism are responsible for vasospastic angina and atherosclerosis. To comprehensively evaluate cholesterol metabolism, 18 sterols, including cholesterol, 6 cholesteryl esters (CEs), 3 cholesterol precursors, and 8 ...
Hyun-Hwa Son +5 more
doaj +1 more source
Journal of Lipid Research, 1997 7-Hydroperoxycholesterols (7OOHs) are intermediates in cholesterol oxidation and potential cytotoxins. A normal-phase HPLC method with UV (205 nm) detection was developed that could resolve 7 alpha OOH, 7 beta OOH, 7-ketocholesterol (7K), and the ...
A J Brown, S L Leong, R T Dean, W Jessup
doaj +1 more source