Results 1 to 10 of about 15,043 (134)

Application of Virtual Twin PBPK Models in Individuals with Obesity via CYP3A4 Phenotyping Using Endogenous Biomarker Data. [PDF]

Clin Pharmacol Ther
Plasma 4β‐hydroxycholesterol (4β‐OHC) normalized for the levels of its parent cholesterol (4β‐OHC/C) is an endogenous biomarker for hepatic CYP3A4. This study evaluated CYP3A4 activity longitudinally in individuals while their obesity status was changing. 4β‐OHC/C was measured pre‐surgery (n = 54) and 2 years after Roux‐en‐Y gastric bypass (n = 30) and
Izat N, Kangne H, Jansson-Löfmark R, Hertel JK, Rostami-Hodjegan A, Robertsen I, Galetin A.   +6 more
europepmc   +2 more sources

Pharmacokinetic profiling of imatinib in relation to CYP3A4 activity in leukaemia patients. [PDF]

Br J Clin Pharmacol
Aim Imatinib pharmacokinetics exhibit large interindividual variability because of differences in CYP3A4 activity—the main imatinib‐metabolizing enzyme. While therapeutic drug monitoring is effective, it requires steady‐state conditions and frequent sampling.
Rasmussen ASB, Koch MR, Rank CU, Andersen CL, Weimann A, Thastrup M, Yang T, Lund TM, Christensen IJ, Nielsen F, Stage TB, Jensen SB, Andersen MK, Schmiegelow K, Dalhoff K.   +14 more
europepmc   +2 more sources

Crossing the barrier: net flux of 27-hydroxycholesterol into the human brain

Journal of Lipid Research, 2005
Side chain oxidizedoxysterols have a unique ability to traverse lipophilic membranes. We tested thehypothesis that there is a net flux of 27-hydroxycholesterol from the circulationinto the brain using plasma samples collected from the internal jugular ...
Ingemar Bjorkhem, Steve Meaney, Dieter Lütjohann   +2 more
exaly   +3 more sources

The cholesterol metabolite 27-hydroxycholesterol inhibits SARS-CoV-2 and is markedly decreased in COVID-19 patients

Redox Biology, 2020
There is an urgent need to identify antivirals against the coronavirus SARS-CoV-2 in the current COVID-19 pandemic and to contain future similar emergencies early on.
Lais Nascimento Alves, Paolo Brambilla, David Lembo   +2 more
exaly   +3 more sources

NCOA4 Accelerates Abdominal Aortic Aneurysm Formation by Regulating Macrophage Activation and Ferroptosis via STAT1-CH25H Axis. [PDF]

Adv Sci (Weinh)
Under pathological stimulation, NCOA4 in macrophages interacts with STAT1 to promote CH25H transcription. The subsequent increase in 25‐HC production activates macrophages, triggers inflammatory responses and ferroptosis, and accelerates the progression of AAA.
Wu Z, Qian Y, Xu W, Liao F, Liu X, Kuang X, Luo G, He X, Jiang L, Ding S.   +9 more
europepmc   +2 more sources

27-hydroxycholesterol and DNA damage repair: implication in prostate cancer

Frontiers in Oncology, 2023
IntroductionWe previously reported that cholesterol homeostasis in prostate cancer (PC) is regulated by 27-hydroxycholesterol (27HC) and that CYP27A1, the enzyme that converts cholesterol to 27HC, is frequently lost in PCs. We observed that restoring the
Gloria Cecilia Galvan, Nadine A. Friedrich, Sanjay Das, Sanjay Das, Sanjay Das, James P. Daniels, Sara Pollan, Shweta Dambal, Ryusuke Suzuki, Sergio E. Sanders, Sungyong You, Hisashi Tanaka, Hisashi Tanaka, Yeon-Joo Lee, Wei Yuan, Johann S. de Bono, Johann S. de Bono, Irina Vasilevskaya, Karen E. Knudsen, Michael R. Freeman, Stephen J. Freedland, Stephen J. Freedland   +21 more
doaj   +1 more source

Bioactive natural compounds as potential medications for osteogenic effects in a molecular docking approach

Frontiers in Pharmacology, 2022
Bone defect repair and fracture healing are critical challenges in clinical treatments. Bioactive natural compounds are potential resources for medications for osteogenic effects.
Yuqiong Wu, Yuqiong Wu, Yulan Liu, Yulan Liu, Yuanjin Xu, Yuanjin Xu, Ao Zheng, Ao Zheng, Jiahui Du, Jiahui Du, Lingyan Cao, Junfeng Shi, Xinquan Jiang, Xinquan Jiang   +13 more
doaj   +1 more source

Oxysterol 7-α Hydroxylase (CYP7B1) Attenuates Metabolic-Associated Fatty Liver Disease in Mice at Thermoneutrality

Cells, 2021
Ambient temperature is an important determinant of both the alternative bile acid synthesis pathway controlled by oxysterol 7-α hydroxylase (CYP7B1) and the progression of metabolic-associated fatty liver disease (MAFLD).
Ioannis Evangelakos, Dorothee Schwinge, Anna Worthmann, Clara John, Niklas Roeder, Paul Pertzborn, Janina Behrens, Christoph Schramm, Ludger Scheja, Joerg Heeren   +9 more
doaj   +1 more source

Cholesterol metabolism: from lipidomics to immunology

Journal of Lipid Research, 2022
Oxysterols, the oxidized forms of cholesterol or of its precursors, are formed in the first steps of cholesterol metabolism. Oxysterols have interested chemists, biologists, and physicians for many decades, but their exact biological relevance in vivo ...
William J. Griffiths, Yuqin Wang
doaj   +1 more source

Oxysterols as Reliable Markers of Quality and Safety in Cholesterol Containing Food Ingredients and Products

Frontiers in Nutrition, 2022
Cholesterol is a lipid of high nutritional value that easily undergoes oxidation through enzymatic and non-enzymatic pathways, leading to a wide variety of cholesterol oxidation products (COPs), more commonly named oxysterols.
Federico Canzoneri, Valerio Leoni, Ginevra Rosso, Davide Risso, Roberto Menta, Giuseppe Poli   +5 more
doaj   +1 more source