Results 1 to 10 of about 16,625 (183)

Liver X Receptor α (LXRα) Regulates 5β-Reductase (AKR1D1) Expression in Avian Embryos: Implications for Yolk Steroid Metabolism. [PDF]

J Exp Zool A Ecol Integr Physiol
ABSTRACT Steroid‐mediated maternal effects are well‐studied as a source of phenotypic variation. In bird eggs, the yolk contains various steroids that can influence embryonic development. However, one complicating factor in understanding how yolk steroids affect development is that the embryo metabolizes yolk steroids to regulate exposure.
Paitz RT, Waters SE, Reynolds DK, Drew EM, Harders EP.   +4 more
europepmc   +2 more sources

Crossing the barrier: net flux of 27-hydroxycholesterol into the human brain

Journal of Lipid Research, 2005
Side chain oxidizedoxysterols have a unique ability to traverse lipophilic membranes. We tested thehypothesis that there is a net flux of 27-hydroxycholesterol from the circulationinto the brain using plasma samples collected from the internal jugular ...
Steve Meaney, Dieter Lütjohann, Ulf Diczfalusy   +2 more
exaly   +3 more sources

The cholesterol metabolite 27-hydroxycholesterol inhibits SARS-CoV-2 and is markedly decreased in COVID-19 patients

Redox Biology, 2020
There is an urgent need to identify antivirals against the coronavirus SARS-CoV-2 in the current COVID-19 pandemic and to contain future similar emergencies early on.
Alessandro Marcello, Rafaela Milan Bonotto, Lais Nascimento Alves   +2 more
exaly   +3 more sources

Targeting Brain Cholesterol Homeostasis in Alzheimer's Disease: Mechanisms and Therapeutic Perspectives. [PDF]

J Neurochem
Brain cholesterol homeostasis is tightly regulated and largely independent of peripheral cholesterol. This review proposes a unifying framework in which aging, sex, and related biological stressors, including hypercholesterolemia, neurodegeneration, inflammation, and oxidative stress, converge to disrupt cholesterol homeostasis in the brain ...
Ruthirakuhan M, Taha AY, Swardfager W.
europepmc   +2 more sources

27-hydroxycholesterol and DNA damage repair: implication in prostate cancer

Frontiers in Oncology, 2023
IntroductionWe previously reported that cholesterol homeostasis in prostate cancer (PC) is regulated by 27-hydroxycholesterol (27HC) and that CYP27A1, the enzyme that converts cholesterol to 27HC, is frequently lost in PCs. We observed that restoring the
Gloria Cecilia Galvan, Nadine A. Friedrich, Sanjay Das, Sanjay Das, Sanjay Das, James P. Daniels, Sara Pollan, Shweta Dambal, Ryusuke Suzuki, Sergio E. Sanders, Sungyong You, Hisashi Tanaka, Hisashi Tanaka, Yeon-Joo Lee, Wei Yuan, Johann S. de Bono, Johann S. de Bono, Irina Vasilevskaya, Karen E. Knudsen, Michael R. Freeman, Stephen J. Freedland, Stephen J. Freedland   +21 more
doaj   +1 more source

Bioactive natural compounds as potential medications for osteogenic effects in a molecular docking approach

Frontiers in Pharmacology, 2022
Bone defect repair and fracture healing are critical challenges in clinical treatments. Bioactive natural compounds are potential resources for medications for osteogenic effects.
Yuqiong Wu, Yuqiong Wu, Yulan Liu, Yulan Liu, Yuanjin Xu, Yuanjin Xu, Ao Zheng, Ao Zheng, Jiahui Du, Jiahui Du, Lingyan Cao, Junfeng Shi, Xinquan Jiang, Xinquan Jiang   +13 more
doaj   +1 more source

Oxysterol 7-α Hydroxylase (CYP7B1) Attenuates Metabolic-Associated Fatty Liver Disease in Mice at Thermoneutrality

Cells, 2021
Ambient temperature is an important determinant of both the alternative bile acid synthesis pathway controlled by oxysterol 7-α hydroxylase (CYP7B1) and the progression of metabolic-associated fatty liver disease (MAFLD).
Ioannis Evangelakos, Dorothee Schwinge, Anna Worthmann, Clara John, Niklas Roeder, Paul Pertzborn, Janina Behrens, Christoph Schramm, Ludger Scheja, Joerg Heeren   +9 more
doaj   +1 more source

Cholesterol metabolism: from lipidomics to immunology

Journal of Lipid Research, 2022
Oxysterols, the oxidized forms of cholesterol or of its precursors, are formed in the first steps of cholesterol metabolism. Oxysterols have interested chemists, biologists, and physicians for many decades, but their exact biological relevance in vivo ...
William J. Griffiths, Yuqin Wang
doaj   +1 more source

Oxysterols as Reliable Markers of Quality and Safety in Cholesterol Containing Food Ingredients and Products

Frontiers in Nutrition, 2022
Cholesterol is a lipid of high nutritional value that easily undergoes oxidation through enzymatic and non-enzymatic pathways, leading to a wide variety of cholesterol oxidation products (COPs), more commonly named oxysterols.
Federico Canzoneri, Valerio Leoni, Ginevra Rosso, Davide Risso, Roberto Menta, Giuseppe Poli   +5 more
doaj   +1 more source

High-temperature GC-MS-based serum cholesterol signatures may reveal sex differences in vasospastic angina

Journal of Lipid Research, 2014
Alterations of cholesterol metabolism are responsible for vasospastic angina and atherosclerosis. To comprehensively evaluate cholesterol metabolism, 18 sterols, including cholesterol, 6 cholesteryl esters (CEs), 3 cholesterol precursors, and 8 ...
Hyun-Hwa Son, Ju-Yeon Moon, Hong Seog Seo, Hyun Hee Kim, Bong Chul Chung, Man Ho Choi   +5 more
doaj   +1 more source