Results 1 to 10 of about 197,113 (113)
The Cross-Talk Between the Peripheral and Brain Cholesterol Metabolisms [PDF]
Current Issues in Molecular BiologyCholesterol is an essential element for the development and normal function of the central nervous system. While peripheral cholesterol is influenced by liver metabolism and diet, brain cholesterol metabolism takes place in an isolated system due to the ...
Ilinca Savulescu-Fiedler +8 more
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Abnormal brain cholesterol homeostasis in Alzheimer’s disease—a targeted metabolomic and transcriptomic study [PDF]
npj Aging and Mechanisms of Disease, 2021 The role of brain cholesterol metabolism in Alzheimer’s disease (AD) remains unclear. Peripheral and brain cholesterol levels are largely independent due to the impermeability of the blood brain barrier (BBB), highlighting the importance of studying the ...
Vijay R. Varma +14 more
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Targeting cytochrome P450 46A1 and brain cholesterol 24-hydroxylation to treat neurodegenerative diseases [PDF]
Exploration of Neuroprotective Therapy, 2021 The brain cholesterol content is determined by the balance between the pathways of in situ biosynthesis and cholesterol elimination via 24-hydroxylation catalyzed by cytochrome P450 46A1 (CYP46A1). Both pathways are tightly coupled and determine the rate
Irina A. Pikuleva
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Cholesterol nose-to-brain delivery as a possible therapeutic strategy in Huntington’s disease [PDF]
Translational NeurodegenerationBackground Huntington’s disease (HD) is a genetically dominant neurodegenerative disorder characterized by several pathological mechanisms, including the disruption of brain cholesterol homeostasis.
Monica Favagrossa +14 more
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Altered Brain Cholesterol Machinery in a Down Syndrome Mouse Model: A Possible Common Feature with Alzheimer’s Disease [PDF]
AntioxidantsDown syndrome (DS) is a complex chromosomal disorder considered as a genetically determined form of Alzheimer’s disease (AD). Maintenance of brain cholesterol homeostasis is essential for brain functioning and development, and its dysregulation is ...
Erica Staurenghi +10 more
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LXR Regulation of Brain Cholesterol: From Development to Disease [PDF]
Trends in Endocrinology and Metabolism, 2016 Gary E Landreth
exaly +2 more sources
Antioxidants, 2023 Statins have been proposed for L-DOPA-induced dyskinesia (LID) treatment. Statin anti-dyskinetic effects were related to the inhibition of the Ras-ERK pathway. However, the mechanisms responsible for the anti-LID effect are unclear.
Andrea Lopez-Lopez +5 more
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Journal of Lipid Research, 2023 The retina and brain are separated from the systemic circulation by the anatomical barriers, which are permeable (the outer blood-retinal barrier) and impermeable (the blood-brain and inner blood-retina barriers) to cholesterol.
Natalia Mast +3 more
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Balancing cholesterol in the brain: from synthesis to disposal
Exploration of Neuroprotective Therapy, 2022 The cholesterol is a vital component of cell membranes and myelin sheaths, and a precursor for essential molecules such as steroid hormones. In humans, cholesterol is partially obtained through the diet, while the majority is synthesized in the body ...
Lydia Qian +3 more
doaj +1 more source
Acta Neuropathologica Communications, 2022 Previous studies show that 3β-hydroxysterol-Δ24 reductase (DHCR24) has a remarked decline in the brain of AD patients. In brain cholesterol synthetic metabolism, DHCR24 is known as the heavily key synthetase in cholesterol synthesis.
Xiaojing Bai +16 more
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