Abnormal brain cholesterol homeostasis in Alzheimer’s disease—a targeted metabolomic and transcriptomic study [PDF]
npj Aging and Mechanisms of Disease, 2021 The role of brain cholesterol metabolism in Alzheimer’s disease (AD) remains unclear. Peripheral and brain cholesterol levels are largely independent due to the impermeability of the blood brain barrier (BBB), highlighting the importance of studying the ...
Vijay R. Varma +14 more
doaj +3 more sources
The Cross-Talk Between the Peripheral and Brain Cholesterol Metabolisms [PDF]
Current Issues in Molecular BiologyCholesterol is an essential element for the development and normal function of the central nervous system. While peripheral cholesterol is influenced by liver metabolism and diet, brain cholesterol metabolism takes place in an isolated system due to the ...
Ilinca Savulescu-Fiedler +8 more
doaj +3 more sources
Brain cholesterol metabolism and Parkinson's disease [PDF]
Movement Disorders, 2019 ABSTRACTBackgroundCirculating cholesterol levels have been linked to PD, but not directly to brain physiology.ObjectiveTo assess whether brain cholesterol metabolism is related to PD.MethodsSixty PD patients and 64 controls were recruited from an academic movement disorder clinic (2009–2012).
Nicholas W Sterling +2 more
exaly +5 more sources
Cholesterol metabolism and homeostasis in the brain [PDF]
Protein and Cell, 2015 Cholesterol is an essential component for neuronal physiology not only during development stage but also in the adult life. Cholesterol metabolism in brain is independent from that in peripheral tissues due to blood-brain barrier. The content of cholesterol in brain must be accurately maintained in order to keep brain function well.
Qiang Liu
exaly +3 more sources
Targeting cytochrome P450 46A1 and brain cholesterol 24-hydroxylation to treat neurodegenerative diseases [PDF]
Exploration of Neuroprotective Therapy, 2021 The brain cholesterol content is determined by the balance between the pathways of in situ biosynthesis and cholesterol elimination via 24-hydroxylation catalyzed by cytochrome P450 46A1 (CYP46A1). Both pathways are tightly coupled and determine the rate
Irina A. Pikuleva
doaj +2 more sources
Neurobiology of Disease, 2017 Cholesterol precursors and cholesterol levels are reduced in brain regions of Huntington's disease (HD) mice. Here we quantified the rate of in vivo de novo cholesterol biosynthesis in the HD brain.
Mahalakshmi Shankaran +11 more
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Soluble Epoxide Hydrolase and Brain Cholesterol Metabolism. [PDF]
Front Mol Neurosci, 2019 The bifunctional enzyme soluble epoxide hydrolase (sEH) is found in all regions of the brain. It has two different catalytic activities, each assigned to one of its terminal domains: the C-terminal domain presents hydrolase activity, whereas the N-terminal domain exhibits phosphatase activity.
Domingues MF +3 more
europepmc +4 more sources
Physiological Functions of Side-Chain-Retaining Sterols in the Brain and Their Roles in Neurodegenerative Diseases [PDF]
MetabolitesAlthough the brain comprises only 2% of total body weight, it contains approximately 23% of the total cholesterol of the body. In the brain, cholesterol plays a critical role as a structural component of cell membranes and myelin sheaths.
Yoshimitsu Kiriyama +4 more
doaj +2 more sources
Altered Brain Cholesterol Machinery in a Down Syndrome Mouse Model: A Possible Common Feature with Alzheimer’s Disease [PDF]
AntioxidantsDown syndrome (DS) is a complex chromosomal disorder considered as a genetically determined form of Alzheimer’s disease (AD). Maintenance of brain cholesterol homeostasis is essential for brain functioning and development, and its dysregulation is ...
Erica Staurenghi +10 more
doaj +2 more sources
LXR Regulation of Brain Cholesterol: From Development to Disease [PDF]
Trends in Endocrinology and Metabolism, 2016 Gary E Landreth
exaly +2 more sources