Results 21 to 30 of about 194,987 (288)

Cholesterol 24-Hydroxylase: An Enzyme of Cholesterol Turnover in the Brain [PDF]

Annual Review of Biochemistry, 2009
Cholesterol 24-hydroxylase is a highly conserved cytochrome P450 that is responsible for the majority of cholesterol turnover in the vertebrate central nervous system. The enzyme is expressed in neurons, including hippocampal and cortical neurons that are important for learning and memory formation. Disruption of the cholesterol 24-hydroxylase gene in
David W, Russell, Rebekkah W, Halford, Denise M O, Ramirez, Rahul, Shah, Tiina, Kotti   +4 more
openaire   +2 more sources

The role of DHCR24 in the pathogenesis of AD: re-cognition of the relationship between cholesterol and AD pathogenesis

Acta Neuropathologica Communications, 2022
Previous studies show that 3β-hydroxysterol-Δ24 reductase (DHCR24) has a remarked decline in the brain of AD patients. In brain cholesterol synthetic metabolism, DHCR24 is known as the heavily key synthetase in cholesterol synthesis.
Xiaojing Bai, Meiting Mai, Kai Yao, Mengqi Zhang, Yue Huang, Wenbin Zhang, Xiaorou Guo, Yixuan Xu, Ying Zhang, Atikam Qurban, Lijie Duan, Jimei Bu, Jianfeng Zhang, Junfeng Wu, Yongfei Zhao, Xiangshan Yuan, Hengbing Zu   +16 more
doaj   +1 more source

Metabolism of cholesteryl palmitate by rat brain in vitro; formation of cholesterol epoxides and cholestane-3β,5α,6β-triol

Journal of Lipid Research, 1973
Incubation of [4-14C] cholesteryl palmitate with the 12,000 g supernatant fraction of adult rat brain fortified with an NADPH-generating system and β-mercaptoethylamine resulted in formation (2–5%) of more polar metabolites characterized as a mixture of ...
Charles M. Martin, Harold J. Nicholas
doaj   +1 more source

Cholesterol Hydroxylating Cytochrome P450 46A1: From Mechanisms of Action to Clinical Applications

Frontiers in Aging Neuroscience, 2021
Cholesterol, an essential component of the brain, and its local metabolism are involved in many neurodegenerative diseases. The blood-brain barrier is impermeable to cholesterol; hence, cholesterol homeostasis in the central nervous system represents a ...
Irina A. Pikuleva, Nathalie Cartier
doaj   +1 more source

Lovastatin exacerbates atypical absence seizures with only minimal effects on brain sterols

Journal of Lipid Research, 2004
AY-9944 (AY) exacerbates chronic recurrent seizures in rats that are analogous to atypical absence epilepsy in humans. The mechanism by which AY affects the slow spike-and-wave discharges associated with these seizures is not known, but is thought to ...
Irina Serbanescu, Mary Ann Ryan, Ruchika Shukla, Miguel A. Cortez, O. Carter Snead, III, Stephen C. Cunnane   +5 more
doaj   +1 more source

Evidence that the major oxysterols in human circulation originate from distinct pools of cholesterol: a stable isotope study

Journal of Lipid Research, 2001
The major oxysterols in human circulation are 7α-, 27-, and (24S)-hydroxycholesterol. Two unique experiments were performed to elucidate their origin and kinetics. A volunteer was exposed to 18O2-enriched air. A rapid incorporation of 18O in both 7α- and
Steve Meaney, Moustapha Hassan, Augustinas Sakinis, Dieter Lütjohann, Klaus von Bergmann, Åke Wennmalm, Ulf Diczfalusy, Ingemar Björkhem   +7 more
doaj   +1 more source

Mixing brain cerebrosides with brain ceramides, cholesterol and phospholipids [PDF]

Scientific Reports, 2019
AbstractThe properties of bilayers composed of pure brain cerebroside (bCrb) or of binary mixtures of bCrb with brain ceramide, cholesterol, egg phosphatidylcholine or brain sphingomyelin have been studied using a combination of physical techniques. Pure bCrb exhibits a rather narrow gel-fluid transition centred at ≈65 °C, with a half-width at half ...
González-Ramírez, Emilio J., Goñi, Félix M., Alonso, Alicia   +2 more
openaire   +4 more sources

GM2/GD2 and GM3 gangliosides have no effect on cellular cholesterol pools or turnover in normal or NPC1 mice

Journal of Lipid Research, 2008
These studies investigated the role of gangliosides in governing the steady-state concentration and turnover of unesterified cholesterol in normal tissues and in those of mice carrying the NPC1 mutation. In animals lacking either GM2/GD2 or GM3 synthase,
Hao Li, Stephen D. Turley, Benny Liu, Joyce J. Repa, John M. Dietschy   +4 more
doaj   +1 more source

The cholesteryl ester transfer protein (CETP) raises cholesterol levels in the brain

Journal of Lipid Research, 2022
The cholesteryl ester transfer protein (CETP) is a lipid transfer protein responsible for the exchange of cholesteryl esters and triglycerides between lipoproteins.
Felix Oestereich, Noosha Yousefpour, Ethan Yang, Jasmine Phénix, Zari Saadati Nezhad, Albert Nitu, Antonio Vázquez Cobá, Alfredo Ribeiro-da-Silva, Pierre Chaurand, Lisa Marie Munter   +9 more
doaj   +1 more source

Family of human oxysterol binding protein (OSBP) homologues: a novel member implicated in brain sterol metabolism

Journal of Lipid Research, 1999
Oxysterol binding protein (OSBP) is a cytosolic protein that undergoes ligand-induced binding to the Golgi apparatus and has been implicated in the regulation of cellular cholesterol metabolism.
Saara Laitinen, Vesa M. Olkkonen, Christian Ehnholm, Elina Ikonen   +3 more
doaj   +1 more source