Cholesterol content in brains of suicide completers [PDF]
The International Journal of Neuropsychopharmacology, 2006 An association between low levels of serum cholesterol and violent or suicidal behaviour has frequently been reported, but it remains unclear how cholesterol in the peripheral system might be related to the brain functions involved in mediating suicidal behaviour.
Aleksandra, Lalovic +6 more
openaire +2 more sources
Extracellular calcium reduction strongly increases the lytic capacity of pneumolysin from streptococcus pneumoniae in brain tissue [PDF]
, 2011 Background. Streptococcus pneumoniae causes serious diseases such as pneumonia and meningitis. Its major pathogenic factor is the cholesterol-dependent cytolysin pneumolysin, which produces lytic pores at high concentrations.
Elke Maier +23 more
core +1 more source
Journal of Lipid Research, 2000 Alzheimer's disease (AD) is characterized by the presence of senile plaques, neurofibrillary tangles, and neuronal cell loss associated with membrane cholesterol release.
Dieter Lütjohann +10 more
doaj +1 more source
Increased protein expression of ABCA1, HMG-CoA reductase, and CYP46A1 induced by garlic and allicin in the brain mouse and astrocytes-isolated from C57BL/6J [PDF]
Avicenna Journal of Phytomedicine, 2021 Objective: Regulation of cholesterol level is essential for the brain optimal function. The beneficial effect of garlic consumption on cholesterol homeostasis is well known; however, the molecular mechanism to support its properties is unclear.
Zahra Nazeri +4 more
doaj +1 more source
Brain cholesterol and suicidal behaviour [PDF]
The International Journal of Neuropsychopharmacology, 2006 Cholesterol is required for growth and replication of all mammalian cells (Yeagle, 1985) and is an obligate precursor of steroid hormones and bile acids. The chemistry and biochemistry of this molecule have attracted much interest due to its role in membrane integrity and function, and in particular due to its association with human diseases ...
openaire +2 more sources
Cholesterol metabolites exported from human brain [PDF]
, 2015 The human brain contains approximately 25% of the body's cholesterol. The brain is separated from the circulation by the blood brain barrier. While cholesterol will not passes this barrier, oxygenated forms of cholesterol can cross the barrier.
Yuqin Wang, William Griffiths
core +2 more sources
Journal of Lipid Research, 1998 We have previously demonstrated that the brain contains about 80% of the 24S-hydroxycholesterol in the human body and that there is a net flux of this steroid from the brain into the circulation (Lütjohann, D. et al. 1996. Proc. Natl. Acad. Sci. USA. 93:
Ingemar Björkhem +5 more
doaj +1 more source
Membrane properties of hydroxycholesterols related to the brain cholesterol metabolism. [PDF]
Beilstein J Org Chem, 2017 Compared to cholesterol, hydroxycholesterols contain an additional hydroxy group in the alkyl chain and are able to efficiently cross the brain–blood barrier. Therefore, they are responsible for the sterol transfer between brain and circulation.
Hilsch M +4 more
europepmc +3 more sources
Cholesterol metabolism as a prognostic marker in patients with mildly symptomatic nonischemic dilated cardiomyopathy [PDF]
, 2017 Background: Little is known about whether the alteration of cholesterol metabolism reflects abdominal organ impairments due to heart failure. Therefore, we investigated the prognostic value of cholesterol metabolism by evaluating serum campesterol and ...
Toru, Kondo +12 more
core +1 more source
Transcriptional and post-translational changes in the brain of mice deficient in cholesterol removal mediated by cytochrome P450 46A1 (CYP46A1). [PDF]
PLoS ONE, 2017 Cytochrome P450 46A1 (CYP46A1) converts cholesterol to 24-hydroxycholesterol and thereby controls the major pathways of cholesterol removal from the brain.
Natalia Mast +4 more
doaj +1 more source