Results 41 to 50 of about 194,987 (288)

Cholesterol and Alzheimer’s Disease; From Risk Genes to Pathological Effects

Frontiers in Aging Neuroscience, 2021
While the central nervous system compromises 2% of our body weight, it harbors up to 25% of the body’s cholesterol. Cholesterol levels in the brain are tightly regulated for physiological brain function, but mounting evidence indicates that excessive ...
Femke M. Feringa, Femke M. Feringa, Rik van der Kant, Rik van der Kant   +3 more
doaj   +1 more source

APOE4 impairs myelination via cholesterol dysregulation in oligodendrocytes

, 2022
APOE4 is the strongest genetic risk factor for Alzheimer’s disease (AD)(1–3). Yet, the effects of APOE4 on the human brain are not fully understood, limiting opportunities to develop targeted therapeutics for APOE4 and other AD risk factors(4–8). To gain
R’Bibo, Lea, Ortlund, Eric A, Ralvenius, William T, Jiang, Xueqiao, Davidson, Shawn M., Blanchard, Joel W, Lin, Yuan-Ta, Kellis, Manolis, Bennett, David A, Kahn, Martin, Davidson, Shawn M, Lavoie, Nicolas, Akay, Leyla Anne, Effenberger, Audrey, Davila-Velderrain, Jose, Ko, Tak, Reyes, Ricardo, Maner-Smith, Kristal, Ng, Ayesha, Ralvenius, William T., Mathys, Hansruedi, Bennett, David A., Blanchard, Joel W., Cam, Hugh P, Bula, Michael, von Maydell, Djuna, Hajjar, Ihab, Agbas, Emre, Tsai, Li-Huei, Liu, Liwang, Ortlund, Eric A., Chen, Chih-Yu, Blanco-Duque, Cristina, Cam, Hugh P.   +33 more
core   +1 more source

Cholesterol retention in Alzheimer's brain is responsible for high β- and γ-secretase activities and Aβ production

Neurobiology of Disease, 2008
Alzheimer's disease (AD) is characterized by overproduction of Aβ derived from APP cleavage via β- and γ-secretase pathway. Recent evidence has linked altered cholesterol metabolism to AD pathogenesis. In this study, we show that AD brain had significant
Huaqi Xiong, Debbie Callaghan, Aimee Jones, Douglas G. Walker, Lih-Fen Lue, Thomas G. Beach, Lucia I. Sue, John Woulfe, Huaxi Xu, Danica B. Stanimirovic, Wandong Zhang   +10 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Cholesterol‐loaded nanoparticles ameliorate synaptic and cognitive function in Huntington's disease mice

EMBO Molecular Medicine, 2015
Brain cholesterol biosynthesis and cholesterol levels are reduced in mouse models of Huntington's disease (HD), suggesting that locally synthesized, newly formed cholesterol is less available to neurons.
Marta Valenza, Jane Y Chen, Eleonora Di Paolo, Barbara Ruozi, Daniela Belletti, Costanza Ferrari Bardile, Valerio Leoni, Claudio Caccia, Elisa Brilli, Stefano Di Donato, Marina M Boido, Alessandro Vercelli, Maria A Vandelli, Flavio Forni, Carlos Cepeda, Michael S Levine, Giovanni Tosi, Elena Cattaneo   +17 more
doaj   +1 more source

cDNA cloning of cholesterol 24-hydroxylase, a mediator of cholesterol homeostasis in the brain [PDF]

Proceedings of the National Academy of Sciences, 1999
The turnover of cholesterol in the brain is thought to occur via conversion of excess cholesterol into 24S-hydroxycholesterol, an oxysterol that is readily secreted from the central nervous system into the plasma. To gain molecular insight into this pathway of cholesterol metabolism, we used expression cloning to isolate cDNAs that encode ...
E G, Lund, J M, Guileyardo, D W, Russell
openaire   +2 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Intracellular Cholesterol Trafficking and Impact in Neurodegeneration

Frontiers in Molecular Neuroscience, 2017
Cholesterol is a critical component of membrane bilayers where it plays key structural and functional roles by regulating the activity of diverse signaling platforms and pathways.
Fabian Arenas, Fabian Arenas, Fabian Arenas, Carmen Garcia-Ruiz, Carmen Garcia-Ruiz, Carmen Garcia-Ruiz, Carmen Garcia-Ruiz, Jose C. Fernandez-Checa, Jose C. Fernandez-Checa, Jose C. Fernandez-Checa, Jose C. Fernandez-Checa   +10 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Characterization of the putative cholesterol transport protein metastatic lymph node 64 in the brain.

, 2006
International audienceIntracellular management of cholesterol is a critical process in the brain. Deficits with cholesterol transport and storage are linked to neurodegenerative disorders such as Neimann-Pick disease type C and Alzheimer's disease.
Alpy, Fabien, Lamb, Dolores J., Tomasetto, Catherine, King, Steven R., Smith, Akemi G. A., Ginsberg, Stephen D.   +5 more
core   +1 more source