Results 11 to 20 of about 194,987 (288)

Effects of a Disrupted Blood-Brain Barrier on Cholesterol Homeostasis in the Brain [PDF]

Journal of Biological Chemistry, 2014
The presence of the blood-brain barrier (BBB) is critical for cholesterol metabolism in the brain, preventing uptake of lipoprotein-bound cholesterol from the circulation. The metabolic consequences of a leaking BBB for cholesterol metabolism have not been studied previously.
Saeed, A. A., Genove, G., Li, T., Lutjohann, D., Olin, M., Mast, N., Pikuleva, I. A., Crick, P., Wang, Y., Griffiths, W., Betsholtz, C., Bjorkhem, I.   +11 more
openaire   +5 more sources

Brain cholesterol in normal and pathological aging [PDF]

Oléagineux, Corps gras, Lipides, 2011
Aberrations in cerebral cholesterol homeostasis can lead to severe neurological diseases. Recent findings strengthen the link between brain cholesterol metabolism and factors involved in synaptic plasticity, a process essential for learning and memory ...
Vanmierlo Tim, Lütjohann Dieter, Mulder Monique   +2 more
doaj   +2 more sources

New insight into the role of altered brain cholesterol metabolism in the pathogenesis of AD: A unifying cholesterol hypothesis and new therapeutic approach for AD

Brain Research Bulletin
The dysregulation of cholesterol metabolism homeostasis has been universally suggested in the aeotiology of Alzheimer's disease (AD). Initially, studies indicate that alteration of serum cholesterol level might contribute to AD.
Xiaobo Yang, Kai Yao, Mengqi Zhang, Wenbin Zhang, Hengbing Zu   +4 more
doaj   +2 more sources

Brain cholesterol and Alzheimer's disease: challenges and opportunities in probe and drug development. [PDF]

Brain
Cholesterol homeostasis is impaired in Alzheimer’s disease (AD), however, attempts to modulate brain cholesterol biology have not translated into tangible clinical benefits for patients to date.
Ahmed H, Wang Y, Griffiths WJ, Levey AI, Pikuleva I, Liang SH, Haider A.   +6 more
europepmc   +2 more sources

Interactions between Angiotensin Type-1 Antagonists, Statins, and ROCK Inhibitors in a Rat Model of L-DOPA-Induced Dyskinesia

Antioxidants, 2023
Statins have been proposed for L-DOPA-induced dyskinesia (LID) treatment. Statin anti-dyskinetic effects were related to the inhibition of the Ras-ERK pathway. However, the mechanisms responsible for the anti-LID effect are unclear.
Andrea Lopez-Lopez, Rita Valenzuela, Ana Isabel Rodriguez-Perez, María J. Guerra, Jose Luis Labandeira-Garcia, Ana Muñoz   +5 more
doaj   +1 more source

Quantitative characterizations of the cholesterol-related pathways in the retina and brain of hamsters

Journal of Lipid Research, 2023
The retina and brain are separated from the systemic circulation by the anatomical barriers, which are permeable (the outer blood-retinal barrier) and impermeable (the blood-brain and inner blood-retina barriers) to cholesterol.
Natalia Mast, Nicole El-Darzi, Yong Li, Irina A. Pikuleva   +3 more
doaj   +1 more source

Lipid rafts, cholesterol, and the brain [PDF]

Neuropharmacology, 2008
Lipid rafts are specialized membrane microdomains that serve as organizing centers for assembly of signaling molecules, influence membrane fluidity and trafficking of membrane proteins, and regulate different cellular processes such as neurotransmission and receptor trafficking.
Zeljka, Korade, Anne K, Kenworthy
openaire   +2 more sources

HDL and cholesterol handling in the brain [PDF]

Cardiovascular Research, 2014
Cholesterol is an essential component of both the peripheral nervous system and central nervous system (CNS) of mammals. Brain cholesterol is synthesized in situ by astrocytes and oligodendrocytes and is almost completely isolated from other pools of cholesterol in the body, but a small fraction can be taken up from the circulation as 27 ...
C. Vitali, C. L. Wellington, L. Calabresi   +2 more
openaire   +4 more sources

Balancing cholesterol in the brain: from synthesis to disposal

Exploration of Neuroprotective Therapy, 2022
The cholesterol is a vital component of cell membranes and myelin sheaths, and a precursor for essential molecules such as steroid hormones. In humans, cholesterol is partially obtained through the diet, while the majority is synthesized in the body ...
Lydia Qian, Amanda B. Chai, Ingrid C. Gelissen, Andrew J. Brown   +3 more
doaj   +1 more source

Growth of cholesterol-reducing Eubacterium on cholesterol-brain agar [PDF]

Applied and Environmental Microbiology, 1980
An agar medium containing 5% cholesterol has been developed for the isolation, enumeration, and characterization of cholesterol-reducing strains of Eubacterium.
A W, Brinkley, A R, Gottesman, G E, Mott
openaire   +2 more sources