Results 11 to 20 of about 2,101,293 (251)

Brain cholesterol and Alzheimer's disease: challenges and opportunities in probe and drug development. [PDF]

Brain
Cholesterol homeostasis is impaired in Alzheimer’s disease (AD), however, attempts to modulate brain cholesterol biology have not translated into tangible clinical benefits for patients to date.
Ahmed H, Wang Y, Griffiths WJ, Levey AI, Pikuleva I, Liang SH, Haider A.   +6 more
europepmc   +2 more sources

Metabolism of cholesteryl palmitate by rat brain in vitro; formation of cholesterol epoxides and cholestane-3β,5α,6β-triol

Journal of Lipid Research, 1973
Incubation of [4-14C] cholesteryl palmitate with the 12,000 g supernatant fraction of adult rat brain fortified with an NADPH-generating system and β-mercaptoethylamine resulted in formation (2–5%) of more polar metabolites characterized as a mixture of ...
Charles M. Martin, Harold J. Nicholas
doaj   +1 more source

Lovastatin exacerbates atypical absence seizures with only minimal effects on brain sterols

Journal of Lipid Research, 2004
AY-9944 (AY) exacerbates chronic recurrent seizures in rats that are analogous to atypical absence epilepsy in humans. The mechanism by which AY affects the slow spike-and-wave discharges associated with these seizures is not known, but is thought to ...
Irina Serbanescu, Mary Ann Ryan, Ruchika Shukla, Miguel A. Cortez, O. Carter Snead, III, Stephen C. Cunnane   +5 more
doaj   +1 more source

Cholesterol Hydroxylating Cytochrome P450 46A1: From Mechanisms of Action to Clinical Applications

Frontiers in Aging Neuroscience, 2021
Cholesterol, an essential component of the brain, and its local metabolism are involved in many neurodegenerative diseases. The blood-brain barrier is impermeable to cholesterol; hence, cholesterol homeostasis in the central nervous system represents a ...
Irina A. Pikuleva, Nathalie Cartier
doaj   +1 more source

Association between cholesterol-phospholipid vesicles and cholesterol crystals in human gallbladder bile [PDF]

, 1989
Rapid aggregation of cholesterol-phospholipid vesicles in gallbladder bile seems to be the first event in the production of cholesterol crystals, a prerequisite for cholesterol gallstone formation.
Schriever, Carolin Erika, Jüngst, Dieter   +1 more
core   +1 more source

Evidence that the major oxysterols in human circulation originate from distinct pools of cholesterol: a stable isotope study

Journal of Lipid Research, 2001
The major oxysterols in human circulation are 7α-, 27-, and (24S)-hydroxycholesterol. Two unique experiments were performed to elucidate their origin and kinetics. A volunteer was exposed to 18O2-enriched air. A rapid incorporation of 18O in both 7α- and
Steve Meaney, Moustapha Hassan, Augustinas Sakinis, Dieter Lütjohann, Klaus von Bergmann, Åke Wennmalm, Ulf Diczfalusy, Ingemar Björkhem   +7 more
doaj   +1 more source

GM2/GD2 and GM3 gangliosides have no effect on cellular cholesterol pools or turnover in normal or NPC1 mice

Journal of Lipid Research, 2008
These studies investigated the role of gangliosides in governing the steady-state concentration and turnover of unesterified cholesterol in normal tissues and in those of mice carrying the NPC1 mutation. In animals lacking either GM2/GD2 or GM3 synthase,
Hao Li, Stephen D. Turley, Benny Liu, Joyce J. Repa, John M. Dietschy   +4 more
doaj   +1 more source

The cholesteryl ester transfer protein (CETP) raises cholesterol levels in the brain

Journal of Lipid Research, 2022
The cholesteryl ester transfer protein (CETP) is a lipid transfer protein responsible for the exchange of cholesteryl esters and triglycerides between lipoproteins.
Felix Oestereich, Noosha Yousefpour, Ethan Yang, Jasmine Phénix, Zari Saadati Nezhad, Albert Nitu, Antonio Vázquez Cobá, Alfredo Ribeiro-da-Silva, Pierre Chaurand, Lisa Marie Munter   +9 more
doaj   +1 more source

Family of human oxysterol binding protein (OSBP) homologues: a novel member implicated in brain sterol metabolism

Journal of Lipid Research, 1999
Oxysterol binding protein (OSBP) is a cytosolic protein that undergoes ligand-induced binding to the Golgi apparatus and has been implicated in the regulation of cellular cholesterol metabolism.
Saara Laitinen, Vesa M. Olkkonen, Christian Ehnholm, Elina Ikonen   +3 more
doaj   +1 more source

Plasma 24S-hydroxycholesterol (cerebrosterol) is increased in Alzheimer and vascular demented patients

Journal of Lipid Research, 2000
Alzheimer's disease (AD) is characterized by the presence of senile plaques, neurofibrillary tangles, and neuronal cell loss associated with membrane cholesterol release.
Dieter Lütjohann, Andreas Papassotiropoulos, Ingemar Björkhem, Sandra Locatelli, Metin Bagli, Randi D. Oehring, Uwe Schlegel, Frank Jessen, Marie Luise Rao, Klaus von Bergmann, Reinhard Heun   +10 more
doaj   +1 more source