Results 11 to 20 of about 17,936 (215)
Metabolism of 4β-Hydroxycholesterol in Humans [PDF]
Journal of Biological Chemistry, 2002 One of the major oxysterols in the human circulation is 4 beta-hydroxycholesterol formed from cholesterol by the drug-metabolizing enzyme cytochrome P450 3A4. Deuterium-labeled 4 beta-hydroxycholesterol was injected into two healthy volunteers, and the apparent half-life was found to be 64 and 60 h, respectively.
Karl, Bodin +8 more
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Clinical and Translational SciencePlasma 4β‐hydroxycholesterol (OHC) has drawn attention as an endogenous substrate indicating CYP3A activity. Plasma 4β‐OHC is produced by hydroxylation by CYP3A4 and CYP3A5 and by cholesterol autoxidation.
Ayako Oda +14 more
doaj +3 more sources
, 1991 High- and low-energy collision experiments, by means of double-focusing and ion-trap mass spectrometers, respectively, performed on the M+. and [M-H2O]+. ions of 7-alpha- and 7-beta-hydroxycholesterol lead to a clear structural characterization of the two stereoisomers.
FAVRETTO, DONATA +5 more
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Inhibition of pathogenic non-enveloped viruses by 25-hydroxycholesterol and 27-hydroxycholesterol [PDF]
Scientific Reports, 2014 AbstractRecent studies reported a broad but selective antiviral activity of 25-hydroxycholesterol (25HC) against enveloped viruses, being apparently inactive against non-enveloped viruses. Here we show that 25HC is endowed with a marked antiviral activity against three pathogenic non-enveloped viruses, i.e.
CIVRA, ANDREA +6 more
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, 2021 Miconazole is effective in treating inflammatory skin conditions and has well-established antifungal effects. To elucidate the underlying mechanisms mediating its additional beneficial effects, we assessed whether miconazole influences the inflammation ...
Seong-Kug Eo (3850609) +5 more
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25-Hydroxycholesterol and 27-hydroxycholesterol induce neuroinflammation by activating microglia
, 2023 Abstract Interleukin-1β (IL-1β) levels and side-chain oxygenated cholesterol molecules (oxysterols) are elevated in the brains of patients with Alzheimer’s disease (AD), and high cholesterol levels increase the risk of AD. However, roles of high cholesterol and side-chain oxysterols in IL-1β expression remain to be determined.
Yonghae Son +4 more
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Journal of Lipid Research, 2014 Alterations of cholesterol metabolism are responsible for vasospastic angina and atherosclerosis. To comprehensively evaluate cholesterol metabolism, 18 sterols, including cholesterol, 6 cholesteryl esters (CEs), 3 cholesterol precursors, and 8 ...
Hyun-Hwa Son +5 more
doaj +1 more source
Journal of Lipid Research, 1999 Oxysterol binding protein (OSBP) is a cytosolic protein that undergoes ligand-induced binding to the Golgi apparatus and has been implicated in the regulation of cellular cholesterol metabolism.
Saara Laitinen +3 more
doaj +1 more source
Quantitative detection of free 24S-hydroxycholesterol, and 27-hydroxycholesterol from human serum [PDF]
BMC Neuroscience, 2014 Cholesterol metabolism is important for the maintenance of myelin and neuronal membranes in the central nervous system. Blood concentrations of the brain specific cholesterol metabolite 24S-hydroxysterol to the peripheral metabolite 27-hydroxycholesterol may be useful surrogate markers for neurodegenerative diseases including Alzheimer's disease ...
Bandaru, Veera Venkata Ratnam +1 more
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Insights from the Structure of Estrogen Receptor into the Evolution of Estrogens: Implications for Endocrine Disruption [PDF]
, 2011 In the last decade, there has been important progress in understanding the origins and evolution of receptors for adrenal steroids (aldosterone, cortisol) and sex steroids (estradiol, progesterone, testosterone) due to the sequencing of genomes from ...
Michael E. Baker
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