Results 11 to 20 of about 16,625 (183)

DataSheet1_Miconazole Suppresses 27-Hydroxycholesterol-induced Inflammation by Regulating Activation of Monocytic Cells to a Proinflammatory Phenotype.docx

, 2021
Miconazole is effective in treating inflammatory skin conditions and has well-established antifungal effects. To elucidate the underlying mechanisms mediating its additional beneficial effects, we assessed whether miconazole influences the inflammation ...
Seong-Kug Eo (3850609), Koanhoi Kim (625698), Yonghae Son (3850612), Dongjun Lee (256900), Bo-Young Kim (516332), Hyok-rae Cho (3850606)   +5 more
core   +1 more source

Family of human oxysterol binding protein (OSBP) homologues: a novel member implicated in brain sterol metabolism

Journal of Lipid Research, 1999
Oxysterol binding protein (OSBP) is a cytosolic protein that undergoes ligand-induced binding to the Golgi apparatus and has been implicated in the regulation of cellular cholesterol metabolism.
Saara Laitinen, Vesa M. Olkkonen, Christian Ehnholm, Elina Ikonen   +3 more
doaj   +1 more source

Regulation of acyl CoA:cholesterol acyltransferase by 25-hydroxycholesterol in rabbit intestinal microsomes and absorptive cells.

Journal of Lipid Research, 1983
The regulation of rabbit intestinal acyl CoA:cholesterol acyltransferase (ACAT) by 25-hydroxycholesterol was studied. 25-Hydroxycholesterol significantly increased jejunal microsomal ACAT activity.
F J Field, S N Mathur
doaj   +1 more source

Bile acid synthesis in man. II. Determination of 7 α-hydroxycholesterol, (22R)-22-hydroxycholesterol, and 26-hydroxycholesterol in human meconium

Journal of Lipid Research, 1977
7 α-Hydroxycholesterol, (22R)-22-hydroxycholesterol and 26-hydroxycholesterol have been quantitated in human meconium. The method used tetrahydrofuran for extraction and solvolysis of the sulfate esters, liquid partition chromatography for the separation
U Lavy, S Burstein, M Gut, N B Javitt
doaj   +1 more source

Serum 4β-hydroxycholesterol increases during fluconazole treatment

, 2020
Purpose: The antifungal drugs ketoconazole and itraconazole reduce serum concentrations of 4β-hydroxycholesterol, which is a validated marker for hepatic cytochrome P450 (CYP) 3A4 activity.
Kerksiek, Anja, Lötsch, Jörn, Stellaard, Frans, Lütjohann, Dieter, Oertel, Bruno Georg, Oertel, Bruno G   +5 more
core   +2 more sources

Changes in the levels of cerebral and extracerebral sterols in the brain of patients with Alzheimer's disease

Journal of Lipid Research, 2004
24S-hydroxycholesterol is a side-chain oxidized oxysterol formed in the brain that is continuously crossing the blood-brain barrier to reach the circulation. There may be an opposite flux of 27-hydroxycholesterol, which is formed to a lower extent in the
Maura Heverin, Nenad Bogdanovic, Dieter Lütjohann, Thomas Bayer, Irina Pikuleva, Lionel Bretillon, Ulf Diczfalusy, Bengt Winblad, Ingemar Björkhem   +8 more
doaj   +1 more source

Identification and in vivo detection of side-chain hydroxylated metabolites of 4β-hydroxycholesterol

, 2023
Oxysterols are oxidized derivatives of cholesterol that are formed by enzymatic processes or through the action of reactive oxygen species. Several of these bioactive lipids have been shown to be affected and/or play a role in inflammatory processes.
Roumain, Martin, Guillemot-Legris, Owein, Al Houayek, Mireille, Muccioli, Giulio, Mireille Alhouayek, Ameraoui, Hafsa, Martin Roumain, Hafsa Ameraoui, Giulio G. Muccioli, Owein Guillemot-Legris   +9 more
core   +1 more source

On the rate of translocation in vitro and kinetics in vivo of the major oxysterols in human circulation

Journal of Lipid Research, 2002
Oxysterols possess powerful biological activities. Some of their effects on the regulation of key enzymes are similar to those of cholesterol, but are much more potent.
Steve Meaney, Karl Bodin, Ulf Diczfalusy, Ingemar Björkhem   +3 more
doaj   +1 more source

Cholesterol 25-hydroxylation activity of CYP3A

Journal of Lipid Research, 2011
To date, many studies have been conducted using 25-hydroxycholesterol, which is a potent regulator of lipid metabolism. However, the origins of this oxysterol have not been entirely elucidated. Cholesterol 25-hydroxylase is one of the enzymes responsible
Akira Honda, Teruo Miyazaki, Tadashi Ikegami, Junichi Iwamoto, Tomomi Maeda, Takeshi Hirayama, Yoshifumi Saito, Tamio Teramoto, Yasushi Matsuzaki   +8 more
doaj   +1 more source

Chinese hamster ovary cells overexpressing the oxysterol binding protein (OSBP) display enhanced synthesis of sphingomyelin in response to 25-hydroxycholesterol

Journal of Lipid Research, 1999
25-Hydroxycholesterol negatively regulates cholesterol synthesis and activates cholesterol esterification in a variety of cultured cells. Concurrent with these effects, 25-hydroxycholesterol also stimulates the synthesis of sphingomyelin in Chinese ...
Thomas A. Lagace, David M. Byers, Harold W. Cook, Neale D. Ridgway   +3 more
doaj   +1 more source