Results 31 to 40 of about 17,936 (215)

24-Hydroxycholesterol is a substrate for hepatic cholesterol 7α-hydroxylase (CYP7A)

Journal of Lipid Research, 2000
(24S)-Hydroxycholesterol is formed from cholesterol in the brain and is important for cholesterol homeostasis in this organ. Elimination of (24S)-hydroxycholesterol has been suggested to occur in the liver but little is known about the metabolism of this
Maria Norlin, Anders Toll, Ingemar Björkhem, Kjell Wikvall   +3 more
doaj   +1 more source

Oxysterols and Retinal Microvascular Dysfunction as Early Risk Markers for Cardiovascular Disease in Normal, Ageing Individuals

Antioxidants, 2021
The aim of the present paper is to assess the relationship between oxysterol levels and retinal microvascular function in individuals of various age groups, free of clinically evident diseases.
Hala Shokr, Irundika HK Dias, Doina Gherghel   +2 more
doaj   +1 more source

25-Hydroxycholesterol in health and diseases [PDF]

Journal of Lipid Research
Cholesterol is an essential structural component of all membranes of mammalian cells where it plays a fundamental role not only in cellular architecture, but also, for example, in signaling pathway transduction, endocytosis process, receptor functioning and recycling, or cytoskeleton remodeling.
Cindy Nguyen, Julien Saint-Pol, Shiraz Dib, Caroline Pot, Fabien Gosselet   +4 more
openaire   +4 more sources

Serum concentration of 7 alpha-hydroxycholesterol as an indicator of bile acid synthesis in humans.

Journal of Lipid Research, 1995
The serum concentration of 7 alpha-hydroxycholesterol as an indicator of total bile acid synthesis was investigated under different experimental conditions in humans. 7 alpha-Hydroxycholesterol was measured by gas-liquid chromatography-mass spectrometry,
C Hahn, C Reichel, K von Bergmann
doaj   +1 more source

Effects of 26-Aminocholesterol, 27-Hydroxycholesterol, and 25-Hydroxycholesterol on Proliferation and Cholesterol Homeostasis in Arterial Myocytes [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 1995
AbstractThe major relation existing between cell growth and cholesterol homeostasis prompted us to investigate the effect of 26-aminocholesterol (26-NH2), 27-hydroxycholesterol (27-OH), and 25-hydroxycholesterol (25-OH) on these cellular events. To test this relation, we incubated human and rat arterial myocytes with the sterols for 72 hours.
A. Corsini, D. Verri, M. Raiteri, P. Quarato, R. Paoletti, R. Fumagalli   +5 more
openaire   +3 more sources

Oxysterols Protect Epithelial Cells Against Pore-Forming Toxins

Frontiers in Immunology, 2022
Many species of bacteria produce toxins such as cholesterol-dependent cytolysins that form pores in cell membranes. Membrane pores facilitate infection by releasing nutrients, delivering virulence factors, and causing lytic cell damage - cytolysis ...
Thomas J. R. Ormsby, Sian E. Owens, Liam Clement, Tom J. Mills, James G. Cronin, John J. Bromfield, Iain Martin Sheldon   +6 more
doaj   +1 more source

Esterified and total 7 alpha-hydroxycholesterol in human serum as an indicator for hepatic bile acid synthesis.

Journal of Lipid Research, 1990
Serum levels of 7 alpha-hydroxycholesterol and activities of hepatic microsomal cholesterol 7 alpha-hydroxylase in surgical patients were analyzed by capillary gas-liquid chromatography-selected ion monitoring technique using a new internal standard, 5 ...
H Oda, H Yamashita, K Kosahara, S Kuroki, F Nakayama   +4 more
doaj   +1 more source

Plasma advanced glycation end products and soluble receptor for advanced glycation end products as indicators of sterol content in human carotid atherosclerotic plaques

Diabetes & Vascular Disease Research, 2022
Advanced glycation end products (AGEs) are independently related to cardiovascular disease (CVD) and favor cholesterol and oxysterol accumulation in macrophage foam cells.
Raphael S Pinto, Guilherme S Ferreira, Gina Camillo R Silvestre, Monique de Fátima M Santana, Valéria S Nunes, Lucas Ledesma, Paula R Pinto, Sayonara Ivana S de Assis, Ubiratan F Machado, Erasmo S da Silva, Marisa Passarelli   +10 more
doaj   +1 more source

Evidence that the major oxysterols in human circulation originate from distinct pools of cholesterol: a stable isotope study

Journal of Lipid Research, 2001
The major oxysterols in human circulation are 7α-, 27-, and (24S)-hydroxycholesterol. Two unique experiments were performed to elucidate their origin and kinetics. A volunteer was exposed to 18O2-enriched air. A rapid incorporation of 18O in both 7α- and
Steve Meaney, Moustapha Hassan, Augustinas Sakinis, Dieter Lütjohann, Klaus von Bergmann, Åke Wennmalm, Ulf Diczfalusy, Ingemar Björkhem   +7 more
doaj   +1 more source

Inhibition of herpes simplex-1 virus replication by 25-hydroxycholesterol and 27-hydroxycholesterol

Redox Biology, 2017
Oxysterols are known pleiotropic molecules whose antiviral action has been recently discovered. Here reported is the activity of a panel of oxysterols against HSV-1 with the identification of a new mechanism of action. A marked antiviral activity not only of 25HC but also of 27HC against HSV-1 was observed either if the oxysterols were added before or ...
CAGNO, VALERIA, CIVRA, ANDREA, ROSSIN, DANIELA, CALFAPIETRA, SIMONE, Caccia, Claudio, Leoni, Valerio, Dorma, Nicholas, BIASI, Fiorella, POLI, Giuseppe, LEMBO, David   +9 more
openaire   +4 more sources