Results 51 to 60 of about 17,936 (215)
Effects of drugs and sterols on cholesterol 7 alpha-hydroxylase activity in rat liver microsomes
Journal of Lipid Research, 1983 This study examined the effects of various drugs and sterols on the rate of 7alpha-hydroxycholesterol synthesis in isolated rat liver microsomes. Cholesterol 7alpha-hydroxylase activity was significantly inhibited by proadifen (98%), metyrapone (67 ...
M A Schwartz, S Margolis
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Regulating Lipid Metabolism in Cancer: The Therapeutic Potential of Traditional Chinese Medicine
Phytotherapy Research, EarlyView.By regulating the reprogramming of lipid metabolism in tumor cells, TCM provides a novel strategy for antitumor therapy with reduced toxicity and enhanced efficacy. ABSTRACT Lipid metabolic reprogramming is a key feature of tumor cells to adapt to the microenvironment and plays an important role in tumor growth, invasion, and metastasis.
Yufeng Gao +11 more
wiley +1 more source
Journal of Lipid Research, 1998 We have previously demonstrated that the brain contains about 80% of the 24S-hydroxycholesterol in the human body and that there is a net flux of this steroid from the brain into the circulation (Lütjohann, D. et al. 1996. Proc. Natl. Acad. Sci. USA. 93:
Ingemar Björkhem +5 more
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Se doped ZnO nanoparticles with improved catalytic activity in degradation of Cholesterol [PDF]
Journal of Water and Environmental Nanotechnology, 2018 Pristine and Se doped ZnO nanoparticles (NPs) were successfully synthesized by thermo-mechanical method and their structural, morphological and optical properties are characterized.
Bhavani Nenavathu +2 more
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Novel approaches for drug development against chronic primary pain: A systematic review
British Journal of Pharmacology, EarlyView.Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus +5 more
wiley +1 more source
The oncogenic roles of 27‑hydroxycholesterol in glioblastoma
Oncology Letters, 2019 Glioblastoma is the most frequent primary malignant brain tumor in adults. Oxysterols are oxidation products of cholesterol generated by enzymatic reactions. 27-hydroxycholesterol (27-HC), an oxysterol, is an abundant metabolite of cholesterol. 27-HC significantly accelerates mammary cancer growth, proliferation and progression in experimental models ...
Liu, Lu +4 more
openaire +3 more sources
, 1995 The cytotoxicity of 25-hydroxycholesterol, 26-hydroxycholesterol and its analogue, 26-aminocholesterol was investigated in murine epidermal cell line, HEL-30.
R. Paoletti +4 more
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Studies on the oxysterols 4alpha- and 4beta-hydroxycholesterol
, 2011 Cytochrome P450 (CYP) enzymes catalyze the metabolism of both foreign and endogenous substances such as drugs and steroids. Enzymes in subfamily CYP3A sum up to 30% of the total CYP content in the liver and metabolize about 50% of all drugs.
Hanna Nylén (18685588)
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Cholesterol and 27-hydroxycholesterol 7 alpha-hydroxylation: evidence for two different enzymes.
Journal of Lipid Research, 1993 The use of 2-hydroxypropyl-beta-cyclodextrin as a vehicle for solubilizing cholesterol and 27-hydroxycholesterol has led to a study of their rates of 7 alpha-hydroxylation in microsomal preparations from hamster liver and HepG2 cells.
KO Martin, K Budai, NB Javitt
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The Oral‐Hepatic Axis: Epidemiological and Mechanistic Links Between Periodontal and Liver Diseases
Journal of Periodontal Research, EarlyView.This review summarizes current epidemiological, clinical and mechanistic evidence linking periodontitis and chronic liver diseases, highlighting the oral‐gut‐liver axis, shared immunometabolic and nutritional pathways and opportunities for integrated preventive and therapeutic strategies.
Sinem Esra Sahingur +3 more
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