Results 1 to 10 of about 1,608,305 (236)

27-Hydroxycholesterol in cancer development and drug resistance [PDF]

Journal of Enzyme Inhibition and Medicinal Chemistry
27-Hydroxycholesterol (27HC), a cholesterol metabolite, functions both as a selective oestrogen receptor (ER) modulator and a ligand for liver X receptors (LXRs).
Yaxin Hou, Zhiguang Fu, Chenhui Wang, Paulina Kucharzewska, Yuan Guo, Sihe Zhang   +5 more
doaj   +5 more sources

Connecting the Dots Between Hypercholesterolemia and Alzheimer’s Disease: A Potential Mechanism Based on 27-Hydroxycholesterol [PDF]

Frontiers in Neuroscience, 2022
Alzheimer’s disease (AD), the most common cause of dementia, is a complex and multifactorial disease involving genetic and environmental factors, with hypercholesterolemia considered as one of the risk factors.
Mingan Wu, Mingan Wu, Yingying Zhai, Yingying Zhai, Xiaoyi Liang, Xiaoyi Liang, Weichun Chen, Weichun Chen, Ruiyi Lin, Ruiyi Lin, Linlin Ma, Linlin Ma, Yi Huang, Yi Huang, Di Zhao, Di Zhao, Yong Liang, Yong Liang, Wei Zhao, Wei Zhao, Jiansong Fang, Jiansong Fang, Shuhuan Fang, Shuhuan Fang, Yunbo Chen, Yunbo Chen, Qi Wang, Qi Wang, Weirong Li, Weirong Li   +29 more
doaj   +3 more sources

The cholesterol metabolite 27-hydroxycholesterol inhibits SARS-CoV-2 and is markedly decreased in COVID-19 patients

Redox Biology, 2020
There is an urgent need to identify antivirals against the coronavirus SARS-CoV-2 in the current COVID-19 pandemic and to contain future similar emergencies early on.
Alessandro Marcello, Andrea Civra, Rafaela Milan Bonotto, Lais Nascimento Alves, Sreejith Rajasekharan, Chiara Giacobone, Claudio Caccia, Roberta Cavalli, Marco Adami, Paolo Brambilla, David Lembo, Giuseppe Poli, Valerio Leoni   +12 more
doaj   +3 more sources

Crossing the barrier: net flux of 27-hydroxycholesterol into the human brain

Journal of Lipid Research, 2005
Side chain oxidizedoxysterols have a unique ability to traverse lipophilic membranes. We tested thehypothesis that there is a net flux of 27-hydroxycholesterol from the circulationinto the brain using plasma samples collected from the internal jugular ...
Maura Heverin, Steve Meaney, Dieter Lütjohann, Ulf Diczfalusy, John Wahren, Ingemar Björkhem   +5 more
doaj   +3 more sources

On the regulatory role of side-chain hydroxylated oxysterols in the brain. Lessons from CYP27A1 transgenic and Cyp27a1−/− mice1 [PDF]

Journal of Lipid Research, 2013
The two oxysterols, 27-hydroxycholesterol (27OH) and 24S-hydroxycholesterol (24OH), are both inhibitors of cholesterol synthesis and activators of the liver X receptor (LXR) in vitro.
Zeina Ali, Maura Heverin, Maria Olin, Jure Acimovic, Anita Lövgren-Sandblom, Marjan Shafaati, Ann Båvner, Vardiella Meiner, Eran Leitersdorf, Ingemar Björkhem   +9 more
doaj   +3 more sources

Paroxetine suppresses 27-hydroxycholesterol-induced responses in THP-1 human monocytic cells by regulating the AKT/mTORC1 pathway [PDF]

Scientific Reports
Paroxetine (PRX) is widely prescribed for treating psychiatric disorders. Emerging evidence suggests that PRX can act as an immunosuppressive agent, yet the molecular mechanisms underlying its effects are not fully understood. This study has investigated
Dongha Park, Yonghae Son, Dongjun Lee, Koanhoi Kim   +3 more
doaj   +2 more sources

Adipose Tissue-Derived Mesenchymal Stem Cells Alter Metabolites of Brain Cholesterol Homeostasis in An Alzheimer’s Model [PDF]

Cell Journal, 2023
Objective: Disruption of cholesterol homeostasis in Alzheimer’s disease (AD) plays a crucial role in diseasepathogenesis, making it a potential therapeutic target.
Mehrnaz Karimi Darabi, Zahra Nazeri, Arash Rafeeinia, Seyedeh Pardis Pezeshki, Alireza Kheirollah, Yaghoob Farbood, Maryam Adelipour, Shirin Azizidoost, Maryam Cheraghzadeh   +8 more
doaj   +1 more source

The Plasma Distribution of Non-cholesterol Sterol Precursors and Products of Cholesterol Synthesis and Phytosterols Depend on HDL Concentration

Frontiers in Nutrition, 2022
Non-cholesterol sterols are transported in plasma lipoproteins and are consequently important in cholesterol metabolism. We investigated the distribution of non-cholesterol sterol precursors of cholesterol synthesis (NCSPCS), oxysterols, and phytosterols
Valéria Sutti Nunes, Eliton Juniro da Silva, Guilherme da Silva Ferreira, Sayonara Ivana Santos de Assis, Patrícia Miralda Cazita, Edna Regina Nakandakare, Vanessa Helena de Souza Zago, Eliana Cotta de Faria, Eder Carlos Rocha Quintão   +8 more
doaj   +1 more source

Oxysterols Protect Epithelial Cells Against Pore-Forming Toxins

Frontiers in Immunology, 2022
Many species of bacteria produce toxins such as cholesterol-dependent cytolysins that form pores in cell membranes. Membrane pores facilitate infection by releasing nutrients, delivering virulence factors, and causing lytic cell damage - cytolysis ...
Thomas J. R. Ormsby, Sian E. Owens, Liam Clement, Tom J. Mills, James G. Cronin, John J. Bromfield, Iain Martin Sheldon   +6 more
doaj   +1 more source

Lipid Anti-Lipid Antibody Responses Correlate with Disease Activity in Systemic Lupus Erythematosus [PDF]

, 2013
10.1371/journal.pone.0055639PLoS ...
Abdul Aziz, N., Bowen, L., Ho Xin Pei, E., Jenner, A.M., Jin Hui Chan, S., Jovanović, V., Kemeny, M.D., Lew, F.C., Lim, Y.T., Lyons, P.A., MacAry, P.A., McKinney, E.F., Ng Ai Poh, A., Shui, G., Smith, K.G.C., Wenk, M.R.   +15 more
core   +6 more sources