A silver lining for 24-hydroxycholesterol in Alzheimer's disease: The involvement of the neuroprotective enzyme sirtuin 1. [PDF]
Redox Biol, 2018 It is now established that cholesterol oxidation products (oxysterols) are involved in several events underlying Alzheimer's disease (AD) pathogenesis. Of note, certain oxysterols cause neuron dysfunction and degeneration but, recently, some of them have
Testa G +8 more
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The Controversial Role of 24-S-Hydroxycholesterol in Alzheimer’s Disease
Antioxidants, 2021 The development of Alzheimer’s disease (AD) is influenced by several events, among which the dysregulation of cholesterol metabolism in the brain plays a major role.
Paola Gamba +2 more
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24-Hydroxycholesterol Induces Tau Proteasome-Dependent Degradation via the SIRT1/PGC1α/Nrf2 Pathway: A Potential Mechanism to Counteract Alzheimer's Disease. [PDF]
Antioxidants (Basel), 2023 Considerable evidence indicates that cholesterol oxidation products, named oxysterols, play a key role in several events involved in Alzheimer’s disease (AD) pathogenesis. Although the majority of oxysterols causes neuron dysfunction and degeneration, 24-
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Serum 24-hydroxycholesterol in probable Alzheimer's dementia: Reexploring the significance of a tentative Alzheimer's disease biomarker. [PDF]
Aging Med (Milton), 2019 Objective This study measured and analyzed the serum levels of 24‐hydroxycholesterol in patients with probable Alzheimer's disease (AD) and age‐/sex‐matched controls.
Roy D +5 more
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Redox Biology, 2020 There is an urgent need to identify antivirals against the coronavirus SARS-CoV-2 in the current COVID-19 pandemic and to contain future similar emergencies early on.
Alessandro Marcello +2 more
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A novel sex-specific role for 27-hydroxycholesterol in early-onset schizophrenia. [PDF]
Ann Gen PsychiatryBackground Although Schizophrenia is a serious mental illness which more common in adults, it can also manifest in childhood with disease onset before age 18 as “early-onset schizophrenia” (EOS).
Sun Z +8 more
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Targeting Brain Cholesterol Homeostasis in Alzheimer's Disease: Mechanisms and Therapeutic Perspectives. [PDF]
J NeurochemBrain cholesterol homeostasis is tightly regulated and largely independent of peripheral cholesterol. This review proposes a unifying framework in which aging, sex, and related biological stressors, including hypercholesterolemia, neurodegeneration, inflammation, and oxidative stress, converge to disrupt cholesterol homeostasis in the brain ...
Ruthirakuhan M, Taha AY, Swardfager W.
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Adipose Tissue-Derived Mesenchymal Stem Cells Alter Metabolites of Brain Cholesterol Homeostasis in An Alzheimer’s Model [PDF]
Cell Journal, 2023 Objective: Disruption of cholesterol homeostasis in Alzheimer’s disease (AD) plays a crucial role in diseasepathogenesis, making it a potential therapeutic target.
Mehrnaz Karimi Darabi +8 more
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Frontiers in Nutrition, 2022 Non-cholesterol sterols are transported in plasma lipoproteins and are consequently important in cholesterol metabolism. We investigated the distribution of non-cholesterol sterol precursors of cholesterol synthesis (NCSPCS), oxysterols, and phytosterols
Valéria Sutti Nunes +8 more
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Frontiers in Psychiatry, 2021 Accumulating evidence from clinical, genetic, and epidemiologic studies suggest that schizophrenia might be a neuronal development disorder. While oxysterols are important factors in neurodevelopment, it is unknown whether oxysterols might be involved in
Zuoli Sun +11 more
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