Results 1 to 10 of about 13,099 (131)

Serum 24‐hydroxycholesterol in probable Alzheimer's dementia: Reexploring the significance of a tentative Alzheimer's disease biomarker [PDF]

Aging Medicine, 2019
Objective This study measured and analyzed the serum levels of 24‐hydroxycholesterol in patients with probable Alzheimer's disease (AD) and age‐/sex‐matched controls.
Debashree Roy, Sankha Shubhra Chakrabarti, Anindita Banerjee, Pallav Sharma, Atanu Biswas, Sasanka Chakrabarti   +5 more
doaj   +2 more sources

24-Hydroxycholesterol Induces Tau Proteasome-Dependent Degradation via the SIRT1/PGC1α/Nrf2 Pathway: A Potential Mechanism to Counteract Alzheimer’s Disease [PDF]

Antioxidants, 2023
Considerable evidence indicates that cholesterol oxidation products, named oxysterols, play a key role in several events involved in Alzheimer’s disease (AD) pathogenesis. Although the majority of oxysterols causes neuron dysfunction and degeneration, 24-
Gabriella Testa, Serena Giannelli, Barbara Sottero, Erica Staurenghi, Giorgio Giaccone, Paola Caroppo, Paola Gamba, Gabriella Leonarduzzi   +7 more
doaj   +2 more sources

A silver lining for 24-hydroxycholesterol in Alzheimer's disease: The involvement of the neuroprotective enzyme sirtuin 1 [PDF]

Redox Biology, 2018
It is now established that cholesterol oxidation products (oxysterols) are involved in several events underlying Alzheimer's disease (AD) pathogenesis. Of note, certain oxysterols cause neuron dysfunction and degeneration but, recently, some of them have
Gabriella Testa, Erica Staurenghi, Serena Giannelli, Simona Gargiulo, Michela Guglielmotto, Massimo Tabaton, Elena Tamagno, Paola Gamba, Gabriella Leonarduzzi   +8 more
doaj   +2 more sources

The cholesterol metabolite 27-hydroxycholesterol inhibits SARS-CoV-2 and is markedly decreased in COVID-19 patients

Redox Biology, 2020
There is an urgent need to identify antivirals against the coronavirus SARS-CoV-2 in the current COVID-19 pandemic and to contain future similar emergencies early on.
Lais Nascimento Alves, Paolo Brambilla, David Lembo   +2 more
exaly   +3 more sources

Application of Virtual Twin PBPK Models in Individuals with Obesity via CYP3A4 Phenotyping Using Endogenous Biomarker Data. [PDF]

Clin Pharmacol Ther
Plasma 4β‐hydroxycholesterol (4β‐OHC) normalized for the levels of its parent cholesterol (4β‐OHC/C) is an endogenous biomarker for hepatic CYP3A4. This study evaluated CYP3A4 activity longitudinally in individuals while their obesity status was changing. 4β‐OHC/C was measured pre‐surgery (n = 54) and 2 years after Roux‐en‐Y gastric bypass (n = 30) and
Izat N, Kangne H, Jansson-Löfmark R, Hertel JK, Rostami-Hodjegan A, Robertsen I, Galetin A.   +6 more
europepmc   +2 more sources

Pharmacokinetic profiling of imatinib in relation to CYP3A4 activity in leukaemia patients. [PDF]

Br J Clin Pharmacol
Aim Imatinib pharmacokinetics exhibit large interindividual variability because of differences in CYP3A4 activity—the main imatinib‐metabolizing enzyme. While therapeutic drug monitoring is effective, it requires steady‐state conditions and frequent sampling.
Rasmussen ASB, Koch MR, Rank CU, Andersen CL, Weimann A, Thastrup M, Yang T, Lund TM, Christensen IJ, Nielsen F, Stage TB, Jensen SB, Andersen MK, Schmiegelow K, Dalhoff K.   +14 more
europepmc   +2 more sources

A novel sex-specific role for 27-hydroxycholesterol in early-onset schizophrenia [PDF]

Annals of General Psychiatry
Background Although Schizophrenia is a serious mental illness which more common in adults, it can also manifest in childhood with disease onset before age 18 as “early-onset schizophrenia” (EOS).
Zuoli Sun, Mingxia Liu, Junjuan Yan, Yuanzhen Wu, Haixia Wang, Yuhong Li, Yilang Tang, Yi Zheng, Rena Li   +8 more
doaj   +2 more sources

The Controversial Role of 24-S-Hydroxycholesterol in Alzheimer’s Disease

Antioxidants, 2021
The development of Alzheimer’s disease (AD) is influenced by several events, among which the dysregulation of cholesterol metabolism in the brain plays a major role.
Erica Staurenghi, Gabriella Testa, Gabriella Leonarduzzi   +2 more
exaly   +3 more sources

Adipose Tissue-Derived Mesenchymal Stem Cells Alter Metabolites of Brain Cholesterol Homeostasis in An Alzheimer’s Model [PDF]

Cell Journal, 2023
Objective: Disruption of cholesterol homeostasis in Alzheimer’s disease (AD) plays a crucial role in diseasepathogenesis, making it a potential therapeutic target.
Mehrnaz Karimi Darabi, Zahra Nazeri, Arash Rafeeinia, Seyedeh Pardis Pezeshki, Alireza Kheirollah, Yaghoob Farbood, Maryam Adelipour, Shirin Azizidoost, Maryam Cheraghzadeh   +8 more
doaj   +1 more source

The Plasma Distribution of Non-cholesterol Sterol Precursors and Products of Cholesterol Synthesis and Phytosterols Depend on HDL Concentration

Frontiers in Nutrition, 2022
Non-cholesterol sterols are transported in plasma lipoproteins and are consequently important in cholesterol metabolism. We investigated the distribution of non-cholesterol sterol precursors of cholesterol synthesis (NCSPCS), oxysterols, and phytosterols
Valéria Sutti Nunes, Eliton Juniro da Silva, Guilherme da Silva Ferreira, Sayonara Ivana Santos de Assis, Patrícia Miralda Cazita, Edna Regina Nakandakare, Vanessa Helena de Souza Zago, Eliana Cotta de Faria, Eder Carlos Rocha Quintão   +8 more
doaj   +1 more source