Results 21 to 30 of about 4,101,858 (162)

DataSheet1_Miconazole Suppresses 27-Hydroxycholesterol-induced Inflammation by Regulating Activation of Monocytic Cells to a Proinflammatory Phenotype.docx

, 2021
Miconazole is effective in treating inflammatory skin conditions and has well-established antifungal effects. To elucidate the underlying mechanisms mediating its additional beneficial effects, we assessed whether miconazole influences the inflammation ...
Seong-Kug Eo (3850609), Koanhoi Kim (625698), Yonghae Son (3850612), Dongjun Lee (256900), Bo-Young Kim (516332), Hyok-rae Cho (3850606)   +5 more
core   +1 more source

Oxygenation of desmosterol and cholesterol in cell cultures.

Journal of Lipid Research, 1990
In order to determine whether hydration of the delta 24 bond of desmosterol contributes to the formation of the regulatory oxysterol, 25-hydroxycholesterol, [3H]desmosterol was incubated with two cultured cell lines and the labeled products were analyzed.
SE Saucier, AA Kandutsch, AK Gayen, JA Nelson, TA Spencer   +4 more
doaj   +1 more source

Quantitative characterizations of the cholesterol-related pathways in the retina and brain of hamsters

Journal of Lipid Research, 2023
The retina and brain are separated from the systemic circulation by the anatomical barriers, which are permeable (the outer blood-retinal barrier) and impermeable (the blood-brain and inner blood-retina barriers) to cholesterol.
Natalia Mast, Nicole El-Darzi, Yong Li, Irina A. Pikuleva   +3 more
doaj   +1 more source

Cholesterol homeostasis in human brain: turnover of 24S-hydroxycholesterol and evidence for a cerebral origin of most of this oxysterol in the circulation

Journal of Lipid Research, 1998
We have previously demonstrated that the brain contains about 80% of the 24S-hydroxycholesterol in the human body and that there is a net flux of this steroid from the brain into the circulation (Lütjohann, D. et al. 1996. Proc. Natl. Acad. Sci. USA. 93:
Ingemar Björkhem, Dieter Lütjohann, Ulf Diczfalusy, Lars Ståhle, Gunvor Ahlborg, John Wahren   +5 more
doaj   +1 more source

Insights from the Structure of Estrogen Receptor into the Evolution of Estrogens: Implications for Endocrine Disruption [PDF]

, 2011
In the last decade, there has been important progress in understanding the origins and evolution of receptors for adrenal steroids (aldosterone, cortisol) and sex steroids (estradiol, progesterone, testosterone) due to the sequencing of genomes from ...
Michael E. Baker
core   +1 more source

High levels of (24S)-24-hydroxycholesterol 3-sulfate, 24-glucuronide in the serum and urine of children with severe cholestatic liver disease

Journal of Lipid Research, 1997
Extracts of urine and serum from children with cholestatic liver disease were analyzed by fast atom bombardment (FAB) mass spectrometry. About half of all spectra showed a peak at m/z 657, compatible with the presence of a glucuronidated cholestenediol ...
L J Meng, W J Griffiths, H Nazer, Y Yang, J Sjövall   +4 more
doaj   +1 more source

27-Hydroxycholesterol: production rates in normal human subjects

Journal of Lipid Research, 1999
We attempted to quantitate production of bile acid via the 27-hydroxylation pathway in six human subjects. After bolus intravenous injection of known amounts of [24-14C]cholic acid and [24-14C]chenodeoxycholic acid, each subject underwent a constant ...
William C. Duane, Norman B. Javitt
doaj   +1 more source

Cholesterol 25-hydroxylation activity of CYP3A

Journal of Lipid Research, 2011
To date, many studies have been conducted using 25-hydroxycholesterol, which is a potent regulator of lipid metabolism. However, the origins of this oxysterol have not been entirely elucidated. Cholesterol 25-hydroxylase is one of the enzymes responsible
Akira Honda, Teruo Miyazaki, Tadashi Ikegami, Junichi Iwamoto, Tomomi Maeda, Takeshi Hirayama, Yoshifumi Saito, Tamio Teramoto, Yasushi Matsuzaki   +8 more
doaj   +1 more source

Side chain hydroxylation of cholesterol, campesterol and β-sitosterol in rat liver mitochondria

Journal of Lipid Research, 1976
The extent of the side chain hydroxylation of cholesterol, campesterol (24 α-methylcholesterol), and β-sitosterol (24 α-ethylcholesterol) in rat liver mitochondria has been compared.
L Aringer, P Eneroth, L Nordström
doaj   +1 more source

24(S)-hydroxycholesterol participates in a liver X receptor-controlled pathway in astrocytes that regulates apolipoprotein E-mediated cholesterol efflux [PDF]

, 2006
Both apolipoprotein E (apoE) and 24(S)-hydroxycholesterol are involved in the pathogenesis of Alzheimer disease (AD). It has been hypothesized that apoE affects AD development via isoform-specific effects on lipid trafficking between astrocytes and ...
Ramaekers, FCS, Wellington, CL, Bakker, AHF, Mulder, M, Bakker, Arjen H. F., Ramaekers, F C S, Hirsch-Reinshagen, V., Ramaekers, F.C.S., Wellington, C L, Hirsch-Reinshagen, Veronica, Abildayeva, K, de Vente, J., Bloks, VW, Bakker, A.H.F., Bloks, V.W., Bakker, A H F, Groen, AK, Kuipers, F., Ramaekers, Frans C. S., Jansen, PJ, Mulder, M., de Vente, Jan, Abildayeva, Karlygash, Jansen, P J, Hirsch Reinshagen, V., Kuipers, F, Bloks, V W, Mulder, Monique, Groen, A K, Kuipers, F; id_orcid, Wellington, C.L., Kuipers, Folkert, Jansen, P.J., Abildayeva, K., Wellington, Cheryl L., Groen, A.K., Jansen, Paula J., de Vente, J, Groen, Albert K., Bloks, Vincent W.   +39 more
core   +3 more sources