Results 41 to 50 of about 13,032 (223)

Coordinated regulation of hepatic and adipose tissue transcriptomes by the oral administration of an amino acid mixture simulating the larval saliva of Vespa species [PDF]

, 2016
Genes mapped on Fig. 3.
Akihito Yasuoka, Asuka Kamei, Fumika Shinozaki, Kaori Kondo, Keiko Abe, Kosuke Shimada, Kota Kumagai, Soichi Arai, Takashi Abe, Takashi Kondo, Yuki Watanabe   +10 more
core   +4 more sources

Excitotoxicity increases the release of 24S-hydroxycholesterol via CYP46A1 activation [PDF]

Molecular Neurodegeneration, 2013
Background Excitotoxicity, a common hallmark of different neurological disorders including Alzheimer’s disease (AD), is the consequence of exacerbated neuronal stimulation and leads to a high influx of calcium trough membrane glutamate receptors [1]. On the other hand, high levels of the cholesterol metabolite 24S-hydroxycholesterol (24-HC) have been ...
Sodero, Alejandro, Vriens, Joris, Ghosh, Debapriya, Stegner, David, Brachet, Anna, Pallotto, Marta, Sassoe-Pognetto, Marco, Brouwers, Jos, Helms, Bernd, Nieswandt, Bernard, Voets, Thomas, Dotti, Carlos   +11 more
openaire   +1 more source

On the rate of translocation in vitro and kinetics in vivo of the major oxysterols in human circulation

Journal of Lipid Research, 2002
Oxysterols possess powerful biological activities. Some of their effects on the regulation of key enzymes are similar to those of cholesterol, but are much more potent.
Steve Meaney, Karl Bodin, Ulf Diczfalusy, Ingemar Björkhem   +3 more
doaj   +1 more source

Reduced Plasma Levels of 25-Hydroxycholesterol and Increased Cerebrospinal Fluid Levels of Bile Acid Precursors in Multiple Sclerosis Patients [PDF]

, 2016
Multiple sclerosis (MS) is an autoimmune, inflammatory disease of the central nervous system (CNS). We have measured the levels of over 20 non-esterified sterols in plasma and cerebrospinal fluid (CSF) from patients suffering from MS, inflammatory CNS ...
A Reboldi, A Saeed, A Solomon, A Szanto, AH Beecham, Andreas W. Sailer, B Goodwin, BA Janowski, C Hong, C Liu, CY Lee, D Meffre, DJ Parks, DR Bauman, DW Russell, F Chalmin, H Lassmann, I Björkhem, I Björkhem, I Björkhem, J Brown III, J Zhang, Jens Kuhle, JG Cyster, JG McDonald, JM Lehmann, Jonas Abdel-Khalik, Juan Zhang, K Park, L Mateos, LH Kasper, M Blanc, M Inoue, M Ogundare, MA Friese, Martin Beibel, N Zelcer, NJ Spann, P Soroosh, Peter J. Crick, PJ Crick, S Hannedouche, S Meaney, S Theofilopoulos, SV Ramagopalan, SY Liu, U Diczfalusy, V Leoni, William J. Griffiths, Y Wang, Yuqin Wang, Z Wang   +51 more
core   +1 more source

Modulation of Muller cell membrane organization by 24S‐hydroxycholesterol

Acta Ophthalmologica, 2017
PurposeMuller glial cells (MGC) are involved in the retinal homeostasis and they are sustaining cholesterol homeostasis. A lack or an excess of cholesterol in neurons can cause neuro‐degeneration. Cholesterol is eliminated from the retina mainly as 24S‐hydroxycholesterol (24S‐OHC).
P.H. Gabrielle, S. Gambert, E. Masson, E. Leger‐Charnay, A. Ferrerro, A. Vannier, C. Gendrault, M. Lachot, C. Creuzot‐Garcher, A. Bon, S. Gregoire, L. Leclere, L. Martine, G. Lucchi, C. Truntzer, L. Bretillon   +15 more
openaire   +1 more source

Oxidation of 7-dehydrocholesterol and desmosterol by human cytochrome P450 46A1[S]

Journal of Lipid Research, 2014
Cytochrome P450 (P450 or CYP) 46A1 is expressed in brain and has been characterized by its ability to oxidize cholesterol to 24S-hydroxycholesterol. In addition, the same enzyme is known to further oxidize 24S-hydroxycholesterol to the 24,25- and 24,27 ...
Sandeep Goyal, Yi Xiao, Ned A. Porter, Libin Xu, F. Peter Guengerich   +4 more
doaj   +1 more source

A pilot study of the association between maternal mid-pregnancy cholesterol and oxysterol concentrations and labor duration

Lipids in Health and Disease, 2023
Background Previous animal model studies have highlighted a role for cholesterol and its oxidized derivatives (oxysterols) in uterine contractile activity, however, a lipotoxic state associated with hypercholesterolemia may contribute to labor dystocia ...
Todd C. Rideout, Jaclyn Wallace, Xiaozhong Wen, Vanessa M. Barnabei, Kai Ling Kong, Richard W. Browne   +5 more
doaj   +1 more source

Primary open-angle glaucoma: association with cholesterol 24S-hydroxylase (CYP46A1) gene polymorphism and plasma 24-hydroxycholesterol levels

, 2009
Purpose. Genetics has made significant contributions to the study of glaucoma over the past few decades. Cholesterol-24S-hydroxylase (CYP46A1) is a cholesterol-metabolizing enzyme that is especially expressed in retinal ganglion cells.
Acar, Niyazi, Björkhem, Ingemar, Bron, Alain, Brétillon, Lionel, Creuzot Garcher, Catherine, Diczfalusy, Ulf, Fourgeux, Cynthia, Joffre, Corinne, Martine, Lucy   +8 more
core   +3 more sources

Cognition in Multiple sclerosis with special emphasis on MRI findings and cerebrosterol [PDF]

, 2014
Multiple sclerosis (MS) is a progressive inflammatory and degenerative disease of the central nervous system (CNS). This thesis focuses on cognition in MS, with special emphasis on long-term magnetic resonance imaging (MRI) findings and cerebrosterol ...
Bergendal, Gösta
core   +1 more source

The Cross-Talk Between the Peripheral and Brain Cholesterol Metabolisms

Current Issues in Molecular Biology
Cholesterol is an essential element for the development and normal function of the central nervous system. While peripheral cholesterol is influenced by liver metabolism and diet, brain cholesterol metabolism takes place in an isolated system due to the ...
Ilinca Savulescu-Fiedler, Luiza-Roxana Dorobantu-Lungu, Serban Dragosloveanu, Serban Nicolae Benea, Christiana Diana Maria Dragosloveanu, Ana Caruntu, Andreea-Elena Scheau, Constantin Caruntu, Cristian Scheau   +8 more
doaj   +1 more source