Results 1 to 10 of about 1,501 (129)

Efavirenz treatment improves retinal vaso-obliteration and pathological neovascularization in a mouse model of retinopathy of prematurity [PDF]

Frontiers in Medicine
ObjectivesPrevious studies have shown the metabolic and regulatory significance of CYP46A1 in the adult retina; however, its role in the developing retina is unknown. Here, we evaluate CYP46A1 expression and the impact of its activation in the developing
Briah Bailey, Josephine Rudd Zhong Manis, Gayatri Seth, Shubhra Rajpurohit, Allston Oxenrider, Pamela M. Martin, Ravirajsinh N. Jadeja, Menaka C. Thounaojam, Menaka C. Thounaojam, Menaka C. Thounaojam   +9 more
doaj   +2 more sources

CYP46A1-Targeted Treatment Alleviates Long-Term White Matter Injury Following Traumatic Brain Injury by Promoting Cholesterol Metabolic Clearance and Remyelination. [PDF]

CNS Neurosci Ther
Our findings demonstrate that CYP46A1 plays a critical role in regulating cholesterol homeostasis in microglia and that the targeting of CYP46A1 may offer a viable therapeutic approach for traumatic brain injury (TBI). The CYP46A1 activator Efavirenz reduces white matter damage by increasing the levels of the cholesterol metabolite 24OHC, thereby ...
Li L, Shi Y, Luo Q, Guo P, Jin T, Ru X, Jiang Z, Niu Y, Li W, Chen Y, Chen Z.   +10 more
europepmc   +2 more sources

Astrocyte-neuron combined targeting for CYP46A1 gene therapy in Huntington’s disease [PDF]

Acta Neuropathologica Communications
Huntington’s disease (HD) is an autosomal dominant neurodegenerative disease caused by an abnormal expansion of cytosine-adenine-guanosine (CAG) trinucleotidein the huntingtin gene.
Louis-Habib Parsai, Farah Chali, Enejda Subashi, Caroline Zeitouny, Emilie Rey, A. Berniard, William Bitton, Laureline Urli, Lisa Rousselot, Nadège Sarrazin, Véronique Blouin, Wilfried F. A. Den Dunnen, Kristin Michaelsen-Preusse, Martin Korte, Sandro Alves, Nathalie Cartier   +15 more
doaj   +2 more sources

Targeting Brain Cholesterol Homeostasis in Alzheimer's Disease: Mechanisms and Therapeutic Perspectives. [PDF]

J Neurochem
Brain cholesterol homeostasis is tightly regulated and largely independent of peripheral cholesterol. This review proposes a unifying framework in which aging, sex, and related biological stressors, including hypercholesterolemia, neurodegeneration, inflammation, and oxidative stress, converge to disrupt cholesterol homeostasis in the brain ...
Ruthirakuhan M, Taha AY, Swardfager W.
europepmc   +2 more sources

The cholesterol 24-hydroxylase CYP46A1 promotes α-synuclein pathology in Parkinson's disease. [PDF]

PLoS Biology
Parkinson's disease (PD) is a neurodegenerative disease characterized by the death of dopaminergic neurons in the substantia nigra and the formation of Lewy bodies that are composed of aggregated α-synuclein (α-Syn).
Lijun Dai, Jiannan Wang, Lanxia Meng, Xingyu Zhang, Tingting Xiao, Min Deng, Guiqin Chen, Jing Xiong, Wei Ke, Zhengyuan Hong, Lihong Bu, Zhentao Zhang   +11 more
doaj   +2 more sources

Structure–Activity Relationship Study on Soticlestat Derivatives for the Discovery of CYP46A1 (CH24H) Inhibitors [PDF]

Molecules
Dravet syndrome (DS) and Lennox–Gastaut syndrome (LGS) are rare, severe developmental and epileptic encephalopathies with poor prognosis, and novel drugs are urgently needed to meet clinical needs.
Xinwei Hu, Wenqian Huang, Xiaotong Lin, Hao Zhang, Yishu Huang, Jiang Wu, Guilong Zhao   +6 more
doaj   +2 more sources

Treatment with efavirenz extends survival in a Creutzfeldt-Jakob disease model by regulating brain cholesterol metabolism [PDF]

JCI Insight
Prion diseases are fatal, infectious, and incurable neurodegenerative conditions affecting humans and animals, caused by the misfolding of the cellular prion protein (PrPC) into its pathogenic isoform, PrPSc. In humans, sporadic Creutzfeldt-Jakob disease
Tahir Ali, Jessica Cashion, Samia Hannaoui, Hanaa Ahmed-Hassan, Hermann Schatzl, Sabine Gilch   +5 more
doaj   +2 more sources

The multifaceted roles of the transcription factor <i>SP1</i> in the pathogenesis of Alzheimer's disease: From molecular regulation to therapeutic targets. [PDF]

Alzheimers Dement (N Y)
Abstract Alzheimer's disease (AD) is driven by interrelated pathologies, including the accumulation of amyloid β (Aβ), tau pathology, chronic neuroinflammation, and oxidative stress (OS). These pathological processes collectively lead to progressive neurodegeneration.
Lv Z, Liu X, Huang Q, Liu H, Xu Z, Xu P.
europepmc   +2 more sources

Neuronal Cholesterol Deficiency Mediated by Astrocytic SREBP2 Downregulation Leads to Postoperative Cognitive Dysfunction Through Impairment of Hippocampal Synaptic Plasticity and Excitatory Synaptic Transmission. [PDF]

Adv Sci (Weinh)
The results showed that the reduction of plasma 24‐hydroxycholesterol (24‐OHC) was related to the cognitive decline in elderly surgical patients. Neuroinflammation induced by anesthesia and surgery significantly downregulated SREBP2 in hippocampal reactive astrocytes, resulting in reduced cholesterol synthesis.
Huang H, Zhou C, Chen C, Tang H, Dong W, Wan J, Kang W, Sun A, Liu Y, Jin C, Lyu X, Zhu Y, Zhou C, Wu Y.   +13 more
europepmc   +2 more sources

SNPs in cytochromes P450 catalyzing cholesterol degradation in brain are associated with Parkinson’s disease [PDF]

Frontiers in Pharmacology
Besides being an essential structural component of plasma membranes and the precursor of many functional compounds and signaling molecules, cholesterol was also proposed to play a role in the etiology and/or manifestation of Parkinson’s disease (PD ...
Polina Petkova-Kirova, Polina Petkova-Kirova, Anastasia Kolchina, Stephan Baas, Gudrun Wagenpfeil, Marcus Michael Unger, Julia Maria Schulze-Hentrich, Rita Bernhardt   +7 more
doaj   +2 more sources