Efavirenz treatment improves retinal vaso-obliteration and pathological neovascularization in a mouse model of retinopathy of prematurity [PDF]
Frontiers in MedicineObjectivesPrevious studies have shown the metabolic and regulatory significance of CYP46A1 in the adult retina; however, its role in the developing retina is unknown. Here, we evaluate CYP46A1 expression and the impact of its activation in the developing
Briah Bailey +9 more
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Astrocyte-neuron combined targeting for CYP46A1 gene therapy in Huntington’s disease [PDF]
Acta Neuropathologica CommunicationsHuntington’s disease (HD) is an autosomal dominant neurodegenerative disease caused by an abnormal expansion of cytosine-adenine-guanosine (CAG) trinucleotidein the huntingtin gene.
Louis-Habib Parsai +15 more
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Frontiers in Aging Neuroscience, 2020 Polymorphism of the cholesterol-24S-hydroxylase (CYP46A1) gene is thought to be a risk factor for Alzheimer’s disease (AD). A single nucleotide polymorphism (T/C) in intron 2, rs754203, has been confirmed to be implicated in AD.
Hui-Yun Li, Fan Zeng, Hai Yang
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The cholesterol 24-hydroxylase CYP46A1 promotes α-synuclein pathology in Parkinson's disease. [PDF]
PLoS BiologyParkinson's disease (PD) is a neurodegenerative disease characterized by the death of dopaminergic neurons in the substantia nigra and the formation of Lewy bodies that are composed of aggregated α-synuclein (α-Syn).
Lijun Dai +11 more
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Structure–Activity Relationship Study on Soticlestat Derivatives for the Discovery of CYP46A1 (CH24H) Inhibitors [PDF]
MoleculesDravet syndrome (DS) and Lennox–Gastaut syndrome (LGS) are rare, severe developmental and epileptic encephalopathies with poor prognosis, and novel drugs are urgently needed to meet clinical needs.
Xinwei Hu +6 more
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Frontiers in Molecular Neuroscience, 2020 The manipulation of cholesterol and its metabolites has been hypothesized to be therapeutically beneficial for mood disorders, neurodegenerative disorders, and epilepsies.
Michael Popiolek +2 more
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Treatment with efavirenz extends survival in a Creutzfeldt-Jakob disease model by regulating brain cholesterol metabolism [PDF]
JCI InsightPrion diseases are fatal, infectious, and incurable neurodegenerative conditions affecting humans and animals, caused by the misfolding of the cellular prion protein (PrPC) into its pathogenic isoform, PrPSc. In humans, sporadic Creutzfeldt-Jakob disease
Tahir Ali +5 more
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Unbiased insights into the multiplicity of the CYP46A1 brain effects in 5XFAD mice treated with low dose-efavirenz [PDF]
Journal of Lipid ResearchCytochrome P450 46A1 (CYP46A1) is the CNS-specific cholesterol 24-hydroxylase that controls cholesterol elimination and turnover in the brain. In mouse models, pharmacologic CYP46A1 activation with low-dose efavirenz or by gene therapy mitigates the ...
Natalia Mast +2 more
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SNPs in cytochromes P450 catalyzing cholesterol degradation in brain are associated with Parkinson’s disease [PDF]
Frontiers in PharmacologyBesides being an essential structural component of plasma membranes and the precursor of many functional compounds and signaling molecules, cholesterol was also proposed to play a role in the etiology and/or manifestation of Parkinson’s disease (PD ...
Polina Petkova-Kirova +7 more
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Frontiers in Molecular Neuroscience, 2017 Impairment in cholesterol metabolism is associated with many neurodegenerative disorders including Alzheimer's disease (AD). However, the lipid alterations underlying neurodegeneration and the connection between altered cholesterol levels and AD remains ...
Sophie Ayciriex +2 more
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