Results 11 to 20 of about 1,942 (152)

Transcriptional and post-translational changes in the brain of mice deficient in cholesterol removal mediated by cytochrome P450 46A1 (CYP46A1). [PDF]

PLoS ONE, 2017
Cytochrome P450 46A1 (CYP46A1) converts cholesterol to 24-hydroxycholesterol and thereby controls the major pathways of cholesterol removal from the brain.
Natalia Mast, Joseph B Lin, Kyle W Anderson, Ingemar Bjorkhem, Irina A Pikuleva   +4 more
doaj   +2 more sources

Therapeutic implications of altered cholesterol homeostasis mediated by loss of CYP46A1 in human glioblastoma [PDF]

EMBO Molecular Medicine, 2019
Dysregulated cholesterol metabolism is a hallmark of many cancers, including glioblastoma (GBM), but its role in disease progression is not well understood. Here, we identified cholesterol 24‐hydroxylase (CYP46A1), a brain‐specific enzyme responsible for
Mingzhi Han, Shuai Wang, Ning Yang, Xu Wang, Wenbo Zhao, Halala Sdik Saed, Thomas Daubon, Bin Huang, Anjing Chen, Gang Li, Hrvoje Miletic, Frits Thorsen, Rolf Bjerkvig, Xingang Li, Jian Wang   +14 more
doaj   +2 more sources

Is it possible to improve memory function by upregulation of the cholesterol 24S-hydroxylase (CYP46A1) in the brain? [PDF]

PLoS ONE, 2013
We previously described a heterozygous mouse model overexpressing human HA-tagged 24S-hydroxylase (CYP46A1) utilizing a ubiquitous expression vector. In this study, we generated homozygotes of these mice with circulating levels of 24OH 30-60% higher than
Silvia Maioli, Ann Båvner, Zeina Ali, Maura Heverin, Muhammad-Al-Mustafa Ismail, Elena Puerta, Maria Olin, Ahmed Saeed, Marjan Shafaati, Paolo Parini, Angel Cedazo-Minguez, Ingemar Björkhem, Ingemar Björkhem   +12 more
doaj   +2 more sources

Association of angiotensin-converting enzyme, CYP46A1 genes polymorphism with senile cataract

Oman Journal of Ophthalmology, 2017
Background: Senile cataract is the most common type of cataract characterized by gradual progressive thickening of the lens of the eye. Previously, many studies investigated the association between genetic polymorphism and senile cataract.
Syed Tasleem Raza, Shania Abbas, Anu Chandra, Luxmi Singh, Saliha Rizvi, Farzana Mahdi   +5 more
doaj   +2 more sources

Oral administration of repurposed drug targeting Cyp46A1 increases survival times of prion infected mice

Acta Neuropathologica Communications, 2021
Prion diseases are fatal, infectious, and incurable neurodegenerative disorders caused by misfolding of the cellular prion protein (PrPC) into the infectious isoform (PrPSc). In humans, there are sporadic, genetic and infectious etiologies, with sporadic
Tahir Ali, Samia Hannaoui, Satish Nemani, Waqas Tahir, Irina Zemlyankina, Pearl Cherry, Su Yeon Shim, Valerie Sim, Hermann M. Schaetzl, Sabine Gilch   +9 more
doaj   +2 more sources

Modulation of Brain Cholesterol Metabolism through CYP46A1 Overexpression for Rett Syndrome

Pharmaceutics
Rett syndrome (RTT) is a rare neurodevelopmental disorder caused by mutation in the X-linked gene methyl-CpG-binding protein 2 (Mecp2), a ubiquitously expressed transcriptional regulator.
Emilie Audouard, Nicolas Khefif, Béatrix Gillet-Legrand, Fanny Nobilleau, Ouafa Bouazizi, Serena Stanga, Gaëtan Despres, Sandro Alves, Antonin Lamazière, Nathalie Cartier, Françoise Piguet   +10 more
doaj   +2 more sources

Unbiased insights into the multiplicity of the CYP46A1 brain effects in 5XFAD mice treated with low dose-efavirenz

Journal of Lipid Research
Cytochrome P450 46A1 (CYP46A1) is the CNS-specific cholesterol 24-hydroxylase that controls cholesterol elimination and turnover in the brain. In mouse models, pharmacologic CYP46A1 activation with low-dose efavirenz or by gene therapy mitigates the ...
Natalia Mast, Makaya Butts, Irina A. Pikuleva   +2 more
doaj   +2 more sources

Neuronal Cholesterol Accumulation Induced by Cyp46a1 Down-Regulation in Mouse Hippocampus Disrupts Brain Lipid Homeostasis [PDF]

Frontiers in Molecular Neuroscience, 2017
Impairment in cholesterol metabolism is associated with many neurodegenerative disorders including Alzheimer's disease (AD). However, the lipid alterations underlying neurodegeneration and the connection between altered cholesterol levels and AD remains ...
Sophie Ayciriex, Fathia Djelti, Fathia Djelti, Sandro Alves, Sandro Alves, Anne Regazzetti, Mathieu Gaudin, Mathieu Gaudin, Jennifer Varin, Dominique Langui, Ivan Bièche, Eloise Hudry, Delphine Dargère, Patrick Aubourg, Patrick Aubourg, Nicolas Auzeil, Olivier Laprévote, Olivier Laprévote, Nathalie Cartier, Nathalie Cartier   +19 more
doaj   +2 more sources

Characterization of three naturally occurring lignans, sesamol, sesamolin, and sesamin, as potent inhibitors of human cytochrome P450 46A1: Implications for treating excitatory neurotoxicity

Frontiers in Pharmacology, 2022
CYP46A1 is a brain-specific enzyme responsible for cholesterol homeostasis. Inhibition of CYP46A1 activity serves as a therapeutic target for excitatory neurotoxicity.
Jie Du, Jie Du, Xiaodong Chen, Xiaodong Chen, Yongshun Zhao, Tingting Zhao, Tingting Zhao, Dalong Wang, Dalong Wang, Zujia Chen, Zujia Chen, Changyuan Wang, Changyuan Wang, Qiang Meng, Qiang Meng, Jialin Yao, Jialin Yao, Huijun Sun, Huijun Sun, Kexin Liu, Kexin Liu, Jingjing Wu, Jingjing Wu   +22 more
doaj   +1 more source

Increased protein expression of ABCA1, HMG-CoA reductase, and CYP46A1 induced by garlic and allicin in the brain mouse and astrocytes-isolated from C57BL/6J [PDF]

Avicenna Journal of Phytomedicine, 2021
Objective: Regulation of cholesterol level is essential for the brain optimal function. The beneficial effect of garlic consumption on cholesterol homeostasis is well known; however, the molecular mechanism to support its properties is unclear.
Zahra Nazeri, Shirin Azizidoost, Maryam Cheraghzadeh, Asma Mohammadi, Alireza Kheirollah   +4 more
doaj   +1 more source