Results 41 to 50 of about 1,942 (152)

The CH24H metabolite, 24HC, blocks viral entry by disrupting intracellular cholesterol homeostasis

Redox Biology, 2023
Cholesterol-24-hydroxylase (CH24H or Cyp46a1) is a reticulum-associated membrane protein that plays an irreplaceable role in cholesterol metabolism in the brain and has been well-studied in several neuro-associated diseases in recent years.
Yueming Yuan, An Fang, Zongmei Wang, Zhihui Wang, Baokun Sui, Yunkai Zhu, Yuan Zhang, Caiqian Wang, Rong Zhang, Ming Zhou, Huanchun Chen, Zhen F. Fu, Ling Zhao   +12 more
doaj   +1 more source

Bile acid metabolism and signaling in human and animal health: A One Health perspective

iMetaOmics, Volume 3, Issue 3, September 2026.
Bile acids maintain host homeostasis through enterohepatic circulation, microbial transformation, and bile acid receptor signaling, thereby regulating glucose and lipid metabolism, intestinal barrier integrity, and immunity. These effects support human disease intervention and health‐oriented animal production, reducing drug dependence and residue ...
Lei Li, Shuai Liu, Zhijun Cao, Yangchun Cao, Shengru Wu, Lu Deng, Junhu Yao, Jun Zhang   +7 more
wiley   +1 more source

PPAR-γ and CYP46A1 genes polymorphism is associated with Primary Open Angle Glaucoma (POAG) in hypertensive North Indians

Egyptian Journal of Medical Human Genetics, 2017
Background: Involvement of genetic factors like gene polymorphisms was found to contribute significantly to development and progression of Primary Open Angle Glaucoma (POAG) in the last few decades.
Syed Tasleem Raza, Saliha Rizvi, Luxmi Singh, Shania Abbas, Zeashan Haider Zaidi, Farzana Mahdi   +5 more
doaj   +1 more source

Oxysterols in Cancer: From Biosynthesis and Pathophysiology to Targeted Therapeutics

MedComm – Oncology, Volume 5, Issue 3, September 2026.
Mechanisms by which oxysterol targeting may enhance immunotherapy efficacy. This figure illustrates potential metabolic interventions that may improve antitumor immunity by modulating oxysterol related pathways. CH25H modulation may reduce 25‐HC accumulation, promote the conversion of cold tumors into hot tumors, and increase T cell infiltration and PD‐
Haili Shang, Yongsheng Li
wiley   +1 more source

Altered Cholesterol Homeostasis in Huntington’s Disease

Frontiers in Aging Neuroscience, 2022
Huntington’s disease (HD) is an autosomal dominant genetic disorder caused by an expansion of the CAG repeat in the first exon of Huntingtin’s gene.
Radhia Kacher, Radhia Kacher, Coline Mounier, Coline Mounier, Coline Mounier, Jocelyne Caboche, Jocelyne Caboche, Jocelyne Caboche, Sandrine Betuing, Sandrine Betuing, Sandrine Betuing   +10 more
doaj   +1 more source

Cholesterol Drives IFITM3+ Microglia Activation and Induces STING Mediated Neuroinflammation After Ischemic Stroke

CNS Neuroscience &Therapeutics, Volume 32, Issue 8, August 2026.
After ischemic stroke, cholesterol accumulation in microglia is accompanied by the emergence of a pro‐inflammatory IFITM3+ subset with aberrant esterification and lipid droplet buildup. This metabolic stress is linked to mitochondrial dysfunction, STING activation, sustained neuroinflammation, and white matter injury.
Yue Cheng, Yuxi Zhou, Yonghui Chen, Tianni Shen, Yan Li, Chen Chen, Qiuyue Fan, Jie Qi, Peiying Li, Yueman Zhang   +9 more
wiley   +1 more source

In Vitro Activation of Cytochrome P450 46A1 (CYP46A1) by Efavirenz-Related Compounds

, 2020
Cytochrome P450 46A1 (CYP46A1) is a central nervous system-specific enzyme, which catalyzes cholesterol 24-hydroxylation. Currently CYP46A1 is being evaluated in a clinical trial for activation by small doses of the anti-HIV drug efavirenz.
Guengerich, F. Peter, Wilkey, Clayton J., Verwilst, Peter, Mast, Natalia, Pikuleva, Irina A.   +4 more
core   +1 more source

Lipid Metabolism in Central Nervous System Diseases: Pathological Mechanisms and Therapeutic Advances

CNS Neuroscience &Therapeutics, Volume 32, Issue 8, August 2026.
Dysregulated lipid metabolism in CNS diseases: core mechanisms and targeted interventions. Lipid metabolism dysregulation participates in the pathological progression of neurodegenerative diseases, traumatic CNS injuries and cerebrovascular diseases by mediating key pathological processes including abnormal protein aggregation, neuroinflammation, lipid
Jiayan Yuan, Shixue Huang, Kun Jiao, Shu Yang, Xuhui Ge, Wei Liu, Wei Wang, Haoming Shu, Xuhui Zhou   +8 more
wiley   +1 more source

A CYPome-wide study reveals new potential players in the pathogenesis of Parkinson’s disease

Frontiers in Pharmacology, 2023
Genetic and environmental factors lead to the manifestation of Parkinson’s disease (PD) but related mechanisms are only rudimentarily understood. Cytochromes P450 (P450s) are involved in the biotransformation of toxic compounds and in many physiological ...
Philip Hartz, Tobias Fehlmann, Gudrun Wagenpfeil, Marcus Michael Unger, Marcus Michael Unger, Rita Bernhardt   +5 more
doaj   +1 more source

Single‐Nucleus Multiomic Analysis Reveals Immune–Metabolic Reprogramming Consistent With Maladaptive Trained Immunity in HIV‐Associated Neurocognitive Disorders

Glia, Volume 74, Issue 8, August 2026.
Single‐nucleus multiomic profiling of postmortem brain reveals coordinated immune, metabolic, and epigenomic reprogramming in glia of people with HIV consistent with maladaptive trained immunity sustaining neuroinflammation in HAND. ABSTRACT HIV‐associated neurocognitive disorders (HAND) remain prevalent in people with HIV (PWH) despite effective ...
Siera Martinez, Anelia Horvath, Luke Johnson, Tatiana Pushkarsky, Larisa Dubrovsky, Daria Starosyla, Ashley Bastin, Dmitri Sviridov, Michael Bukrinsky   +8 more
wiley   +1 more source