Results 41 to 50 of about 1,473 (145)

CYP46A1 gene therapy deciphers the role of brain cholesterol metabolism in Huntington’s disease [PDF]

Brain, 2019
AbstractDysfunctions in brain cholesterol homeostasis have been extensively related to brain disorders. The main pathway for brain cholesterol elimination is its hydroxylation into 24S-hydroxycholesterol by the cholesterol 24-hydrolase, CYP46A1.
Kacher, Radhia, Lamazière, Antonin, Heck, Nicolas, Kappes, Vincent, Mounier, Coline, Despres, Gaëtan, Dembitskaya, Yulia, Perrin, Elodie, Christaller, Wilhelm, Sasidharan Nair, Satish, Messent, Valérie, Cartier, Nathalie, Vanhoutte, Peter, Venance, Laurent, Saudou, Frédéric, Néri, Christian, Caboche, Jocelyne, Betuing, Sandrine   +17 more
openaire   +3 more sources

A CYPome-wide study reveals new potential players in the pathogenesis of Parkinson’s disease

Frontiers in Pharmacology, 2023
Genetic and environmental factors lead to the manifestation of Parkinson’s disease (PD) but related mechanisms are only rudimentarily understood. Cytochromes P450 (P450s) are involved in the biotransformation of toxic compounds and in many physiological ...
Philip Hartz, Tobias Fehlmann, Gudrun Wagenpfeil, Marcus Michael Unger, Marcus Michael Unger, Rita Bernhardt   +5 more
doaj   +1 more source

CYP46A1 inhibition, brain cholesterol accumulation and neurodegeneration pave the way for Alzheimer’s disease [PDF]

Brain, 2015
Abnormalities in neuronal cholesterol homeostasis have been suspected or observed in several neurodegenerative disorders including Alzheimer's disease, Parkinson's disease and Huntington's disease. However, it has not been demonstrated whether an increased abundance of cholesterol in neurons in vivo contributes to neurodegeneration.
Ayciriex, Sophie, Djelti, Fathia, Braudeau, Jérome, Hudry, Eloise, Dhenain, Marc, Varin, Jennifer, Bieche, Ivan, Marquer, Catherine, Chali, Farah, Auzeil, Nicolas, Alves, Sandro, Langui, Dominique, Potier, Marie-Claude, Laprévote, Olivier, Vidaud, Michel, Duyckaerts, Charles, Miles, Richard, Aubourg, Patrick, Cartier, Nathalie   +18 more
openaire   +2 more sources

Structural Basis of Drug Binding to CYP46A1, an Enzyme That Controls Cholesterol Turnover in the Brain [PDF]

Journal of Biological Chemistry, 2010
Cytochrome P450 46A1 (CYP46A1) initiates the major pathway of cholesterol elimination from the brain and thereby controls cholesterol turnover in this organ. We determined x-ray crystal structures of CYP46A1 in complex with four structurally distinct pharmaceuticals; antidepressant tranylcypromine (2.15 Å), anticonvulsant thioperamide (1.65 Å ...
Natalia, Mast, Casey, Charvet, Irina A, Pikuleva, C David, Stout   +3 more
openaire   +2 more sources

Methylome-wide association study of different responses to risperidone in schizophrenia

Frontiers in Pharmacology, 2022
Background: Accumulating evidence shows that DNA methylation plays a role in antipsychotic response. However, the mechanisms by which DNA methylation changes are associated with antipsychotic responses remain largely unknown.Methods: We performed a ...
Huihui Du, Jingsong Ma, Jingsong Ma, Wei Zhou, Mo Li, Cong Huai, Lu Shen, Hao Wu, Xianglong Zhao, Na Zhang, Songyin Gao, Qi Wang, Lin He, Xuming Wu, Shengying Qin, Mingzhe Zhao, Mingzhe Zhao   +16 more
doaj   +1 more source

HDL inhibits endoplasmic reticulum stress-induced apoptosis of pancreatic β-cells in vitro by activation of Smoothened[S]

Journal of Lipid Research, 2020
Loss of pancreatic β-cell mass and function as a result of sustained ER stress is a core step in the pathogenesis of diabetes mellitus type 2. The complex control of β-cells and insulin production involves hedgehog (Hh) signaling pathways as well as ...
Mustafa Yalcinkaya, Anja Kerksiek, Katrin Gebert, Wijtske Annema, Rahel Sibler, Silvija Radosavljevic, Dieter Lütjohann, Lucia Rohrer, Arnold von Eckardstein   +8 more
doaj   +1 more source

FXR-Mediated Cortical Cholesterol Accumulation Contributes to the Pathogenesis of Type A Hepatic Encephalopathy

Cellular and Molecular Gastroenterology and Hepatology, 2018
Hepatic encephalopathy is a serious neurologic complication of acute and chronic liver diseases. We previously showed that aberrant bile acid signaling contributes to the development of hepatic encephalopathy via farnesoid X receptor (FXR)-mediated ...
Matthew McMillin, Stephanie Grant, Gabriel Frampton, Anca D. Petrescu, Jessica Kain, Elaina Williams, Rebecca Haines, Lauren Canady, Sharon DeMorrow   +8 more
doaj   +1 more source

Deletion of TSPO Causes Dysregulation of Cholesterol Metabolism in Mouse Retina

Cells, 2021
Cholesterol dysregulation has been implicated in age-related macular degeneration (AMD), the most common cause of visual impairment in the elderly.
Fahad Farhan, Mohammad Almarhoun, Aileen Wong, Amy S. Findlay, Chris Bartholomew, Mark T. S. Williams, Toby W. Hurd, Xinhua Shu   +7 more
doaj   +1 more source

Expression profiles of cholesterol metabolism-related genes are altered during development of experimental autoimmune encephalomyelitis in the rat spinal cord

Scientific Reports, 2017
Increased evidence suggests that dysregulation of cholesterol metabolism may be a key event contributing to progression of multiple sclerosis (MS). Using an experimental autoimmune encephalomyelitis (EAE) model of MS we revealed specific changes in the ...
Irena Lavrnja, Kosara Smiljanic, Danijela Savic, Aleksandra Mladenovic-Djordjevic, Katarina Tesovic, Selma Kanazir, Sanja Pekovic   +6 more
doaj   +1 more source

N,N-Dimethyl-3β-hydroxycholenamide Reduces Retinal Cholesterol via Partial Inhibition of Retinal Cholesterol Biosynthesis Rather Than its Liver X Receptor Transcriptional Activity

Frontiers in Pharmacology, 2018
N,N-dimethyl-3β-hydroxycholenamide (DMHCA) is an experimental pharmaceutical and a steroidal liver X receptor (LXR) agonist, which does not induce undesired hepatic lipogenesis.
Nicole El-Darzi, Artem Astafev, Natalia Mast, Aicha Saadane, Morrie Lam, Irina A. Pikuleva   +5 more
doaj   +1 more source