Identification and developmental expression of the full complement of Cytochrome P450 genes in Zebrafish [PDF]
, 2010 Background Increasing use of zebrafish in drug discovery and mechanistic toxicology demands knowledge of cytochrome P450 (CYP) gene regulation and function.
Jared V Goldstone +7 more
core +1 more source
Brain cholesterol in normal and pathological aging [PDF]
, 2011 Aberrations in cerebral cholesterol homeostasis can lead to severe neurological diseases. Recent findings strengthen the link between brain cholesterol metabolism and factors involved in synaptic plasticity, a process essential for learning and memory ...
Lütjohann, D. (Dieter) +2 more
core +5 more sources
Effect of Amyloid Beta on Cholesterol Metabolism-Correlated microRNAs in Primary Cultured Astrocytes of C57BL/6J Mice: A Focus on CYP46A1 and APOE Genes [PDF]
Cell JournalObjective: The accumulation of amyloid plaques and disturbance of cholesterol homeostasis are implicated in thepathophysiology of Alzheimer’s disease. Apolipoprotein E (ApoE) and cholesterol 24-hydroxylase (CYP46A1) are keyproteins involved in the efflux
Bahar Jaberian Asl +6 more
doaj +1 more source
Polymorphisms in brain cholesterol homeostasis pathway as biomarkers for Alzheimer's Disease: meta‐analyses of clinical evidences [PDF]
Alzheimers DementAbstract Background Alzheimer's disease (AD) is a neurodegenerative condition marked by memory loss, cognitive decline, and eventually motor and behavioural dysfunction. Most AD drug trials have failed due to the lack of early intervention, which is crucial for treatment effectiveness.
PRABHA P +5 more
europepmc +2 more sources
Current trends in oxysterol research [PDF]
, 2016 In this short review we provide a synopsis of recent developments in oxysterol research highlighting topics of current interest to the community. These include the involvement of oxysterols in neuronal development and survival, their participation in the
Alvelius +54 more
core +1 more source
Transcriptional regulation of the human CYP46A1 brain‐specific expression by Sp transcription factors [PDF]
Journal of Neurochemistry, 2008 AbstractBrain defective cholesterol homeostasis has been associated with neurologic diseases, such as Alzheimer’s and Huntington’s disease. The elimination of cholesterol from the brain involves its conversion into 24(S)‐hydroxycholesterol by CYP46A1, and the efflux of this oxysterol across the blood–brain barrier.
Milagre, I +6 more
openaire +4 more sources
Drug and xenobiotic biotransformation in the blood–brain barrier: a neglected issue [PDF]
, 2014 Drug biotransformation is a crucial mechanism for facilitating the elimination of chemicals from the organism and for decreasing their pharmacological activity.
Elena GarcÃa-MartÃn +3 more
core +1 more source
Sex-dependent effects of CYP46A1 overexpression on cognitive function during aging [PDF]
, 2021 ABSTRACT Cholesterol turnover and CYP46A1 regulation are reported to be crucial for memory functions. An increasing body of evidence shows that CYP46A1 activation is able to reduce Alzheimer’s Disease (AD) pathological processes.
María Latorre-Leal +16 more
openaire +1 more source
PLoS Biology, 2023 Cholesterol contributes to neuronal membrane integrity, supports membrane protein clustering and function, and facilitates proper signal transduction. Extensive evidence has shown that cholesterol imbalances in the central nervous system occur in aging ...
Alejandro O Sodero +7 more
doaj +1 more source
Antifungal Azoles: Structural Insights into Undesired Tight Binding to Cholesterol-Metabolizing CYP46A1 [PDF]
Molecular Pharmacology, 2013 Although there are currently three generations of antifungal azoles on the market, even the third-generation agents show undesirable interactions with human cytochrome P450 (P450) enzymes. CYP46A1 is a cholesterol-metabolizing P450 in the brain that tightly binds a number of structurally distinct azoles. Previously, we determined the crystal structures
Natalia, Mast +3 more
openaire +2 more sources