Results 51 to 60 of about 1,942 (152)

Methylome-wide association study of different responses to risperidone in schizophrenia

Frontiers in Pharmacology, 2022
Background: Accumulating evidence shows that DNA methylation plays a role in antipsychotic response. However, the mechanisms by which DNA methylation changes are associated with antipsychotic responses remain largely unknown.Methods: We performed a ...
Huihui Du, Jingsong Ma, Jingsong Ma, Wei Zhou, Mo Li, Cong Huai, Lu Shen, Hao Wu, Xianglong Zhao, Na Zhang, Songyin Gao, Qi Wang, Lin He, Xuming Wu, Shengying Qin, Mingzhe Zhao, Mingzhe Zhao   +16 more
doaj   +1 more source

Microglial Mitochondrial Dysfunction: The Storm Center of Post‐Stroke Neuroinflammation

CNS Neuroscience &Therapeutics, Volume 32, Issue 7, July 2026.
Stroke disrupts microglial mitochondrial homeostasis, leading to acute damage and metabolic dysfunction that amplify pro‐inflammatory signaling. Although quality control mechanisms initiate protective responses, persistent stress overwhelms them. The resulting imbalance drives a self‐reinforcing neuroinflammatory storm that exacerbates secondary brain ...
Ruchong Fan, Chuan Wang, Zi Lin, Shiling Chen, Chao Pan, Hao Nie, Chuan Qin, Xuan Wu, Zhouping Tang   +8 more
wiley   +1 more source

Cholesterol-24S-hydroxylase (CYP46A1) is specifically expressed in neurons of the neural retina

, 2007
International audienceIncreasing biological findings argue for the importance of cholesterol-24S-hydroxylase (CYP46A1) in cholesterol homeostasis in cerebral structures.
Brétillon, Lionel, Creuzot-Garcher, C, Martine, Lucy, Creuzot-Garcher, Catherine, Joffre, Corinne, Diczfalusy, Ulf, Creuzot Garcher, Catherine, Martine, L, Diczfalusy, U,, Bron, Alain, M., Bjoerkhem, I, Bron, A, Maire, Marie-Annick, Bjorkhem, Ingemar, Maire, MA, Acar, Niyazi, Acar, N, Bretillon, L, Bron, Alain,, Lucy, Martine, Joffre, C   +20 more
core   +1 more source

Cholesterol metabolism via cyp46a1 in glaucoma

, 2012
Cholesterol metabolism via cyp46a1 in glaucoma.
Brétillon, Lionel, Creuzot-Garcher, Catherine, Bron, Alain, Acar, Niyazi, Fourgeux, Cynthia   +4 more
core   +1 more source

FXR-Mediated Cortical Cholesterol Accumulation Contributes to the Pathogenesis of Type A Hepatic Encephalopathy

Cellular and Molecular Gastroenterology and Hepatology, 2018
Hepatic encephalopathy is a serious neurologic complication of acute and chronic liver diseases. We previously showed that aberrant bile acid signaling contributes to the development of hepatic encephalopathy via farnesoid X receptor (FXR)-mediated ...
Matthew McMillin, Stephanie Grant, Gabriel Frampton, Anca D. Petrescu, Jessica Kain, Elaina Williams, Rebecca Haines, Lauren Canady, Sharon DeMorrow   +8 more
doaj   +1 more source

HDL inhibits endoplasmic reticulum stress-induced apoptosis of pancreatic β-cells in vitro by activation of Smoothened[S]

Journal of Lipid Research, 2020
Loss of pancreatic β-cell mass and function as a result of sustained ER stress is a core step in the pathogenesis of diabetes mellitus type 2. The complex control of β-cells and insulin production involves hedgehog (Hh) signaling pathways as well as ...
Mustafa Yalcinkaya, Anja Kerksiek, Katrin Gebert, Wijtske Annema, Rahel Sibler, Silvija Radosavljevic, Dieter Lütjohann, Lucia Rohrer, Arnold von Eckardstein   +8 more
doaj   +1 more source

A phase 3, randomized clinical trial of soticlestat as adjunctive therapy for Lennox–Gastaut syndrome

Epilepsia, Volume 67, Issue 7, Page 3420-3431, July 2026.
Soticlestat as adjunctive therapy for Lennox–Gastaut syndrome. Abstract Objective There remains a need for new treatments for Lennox–Gastaut syndrome (LGS), a developmental and epileptic encephalopathy with a heterogenous patient population that often requires polytherapy. The phase 3, randomized SKYWAY study (NCT04938427) investigated the efficacy and
Renzo Guerrini, Eric D. Marsh, Wei‐Ping Liao, Katsumi Imai, Ruzica Kravljanac, Anna Altmann, Cecil D. Hahn, Stéphane Auvin, Jimmy Schiemann, Yasir Khan, Pranab Mitra, Sarah I. Sheikh, Philipp von Rosenstiel, Mahnaz Asgharnejad, Dennis Dlugos, Venkatesha Murthy   +15 more
wiley   +1 more source

Chandipura Virus: An Emerging Neurological Threat Transmitted by Sandflies in India

Immunity, Inflammation and Disease, Volume 14, Issue 7, July 2026.
Chandipura virus (CHPV), a neurotropic arbovirus transmitted primarily by sandflies, has emerged as a significant public health concern in India following recurrent outbreaks with high pediatric fatality rates. This review highlights the virus's virology, transmission dynamics, clinical features, and the urgent need for improved diagnostics ...
Abrar Ahmad Zargar, Reena Gupta, P. Krishnamoorthy   +2 more
wiley   +1 more source

Expression profiles of cholesterol metabolism-related genes are altered during development of experimental autoimmune encephalomyelitis in the rat spinal cord

Scientific Reports, 2017
Increased evidence suggests that dysregulation of cholesterol metabolism may be a key event contributing to progression of multiple sclerosis (MS). Using an experimental autoimmune encephalomyelitis (EAE) model of MS we revealed specific changes in the ...
Irena Lavrnja, Kosara Smiljanic, Danijela Savic, Aleksandra Mladenovic-Djordjevic, Katarina Tesovic, Selma Kanazir, Sanja Pekovic   +6 more
doaj   +1 more source

N,N-Dimethyl-3β-hydroxycholenamide Reduces Retinal Cholesterol via Partial Inhibition of Retinal Cholesterol Biosynthesis Rather Than its Liver X Receptor Transcriptional Activity

Frontiers in Pharmacology, 2018
N,N-dimethyl-3β-hydroxycholenamide (DMHCA) is an experimental pharmaceutical and a steroidal liver X receptor (LXR) agonist, which does not induce undesired hepatic lipogenesis.
Nicole El-Darzi, Artem Astafev, Natalia Mast, Aicha Saadane, Morrie Lam, Irina A. Pikuleva   +5 more
doaj   +1 more source