Results 51 to 60 of about 1,473 (145)

Okadaic acid inhibits the trichostatin A-mediated increase of human CYP46A1 neuronal expression in a ERK1/2-Sp3-dependent pathway

Journal of Lipid Research, 2012
The CYP46A1 gene codes for the cholesterol 24-hydroxylase, a cytochrome P450 specifically expressed in neurons and responsible for the majority of cholesterol turnover in the central nervous system.
Maria João Nunes, Miguel Moutinho, Inês Milagre, Maria João Gama, Elsa Rodrigues   +4 more
doaj   +1 more source

Role of Cholesterol Metabolic Enzyme CYP46A1 and Its Metabolite 24S-Hydroxycholesterol in Ischemic Stroke. [PDF]

Stroke
BACKGROUND: For several decades, it has been recognized that overactivation of the glutamate-gated N-methyl-D-aspartate receptors (NMDARs) and subsequent Ca 2+ toxicity play a critical role in ischemic brain injury.
Sun H, Yang T, Simon RP, Xiong ZG, Leng T.   +4 more
europepmc   +4 more sources

Mapping of the Allosteric Site in Cholesterol Hydroxylase CYP46A1 for Efavirenz, a Drug That Stimulates Enzyme Activity [PDF]

Journal of Biological Chemistry, 2016
Cytochrome P450 46A1 (CYP46A1) is a microsomal enzyme and cholesterol 24-hydroxylase that controls cholesterol elimination from the brain. This P450 is also a potential target for Alzheimer disease because it can be activated pharmacologically by some marketed drugs, as exemplified by efavirenz, the anti-HIV medication.
Kyle W, Anderson, Natalia, Mast, Jeffrey W, Hudgens, Joseph B, Lin, Illarion V, Turko, Irina A, Pikuleva   +5 more
openaire   +2 more sources

Histological Study on the Therapeutic Effect of Gene Modified Bone Marrow Hemopoeitic Stem Cells (BMHSCs) Versus Unmodified BMHSCs Derived Exosomes in Early Diabetic Retinopathy Male Rat Model

The Egyptian Journal of Histology
Background and Objectives: Globally, one of the main causes of blindness and vision impairment in the working class is diabetic retinopathy (DR). The goal of the current study was to evaluate and investigate the therapeutic benefits of bone marrow ...
Maha Zickri, Zeinab Hegab, Hala Metwally, Nour Abdelwahab, Hossam El Din Kareem, Mohammed Hameed, layth AbdulAdeem, Taha Yousif, Mohamed AbdelRahman, Amal Farag   +9 more
doaj   +1 more source

CYP46A1variants influence Alzheimer’s disease risk and brain cholesterol metabolism

European Psychiatry, 2009
AbstractBackgroundCholesterol 24S-hydroxylase (CYP46) catalyzes the conversion of cholesterol to 24S-hydroxycholesterol, the primary cerebral cholesterol elimination product. Only few gene variations in CYP46 gene (CYP46A1) have been investigated for their relevance as genetic risk factors of Alzheimer’s disease (AD) and results are contradictory ...
Heike, Kölsch, Dieter, Lütjohann, Frank, Jessen, Julius, Popp, Frank, Hentschel, Peter, Kelemen, Sandra, Schmitz, Wolfgang, Maier, Reinhard, Heun   +8 more
openaire   +2 more sources

Elevated 24-hydroxycholesterol levels counteract okadaic acid-induced tau hyperphosphorylation and neuronal morphology impairment

Neurobiology of Disease
Multiple findings underline a link between altered brain cholesterol metabolism and Alzheimer's disease (AD) pathogenesis. Physiologically, excess brain cholesterol is mainly converted into 24-hydroxycholesterol (24-OHC) by the neuron-specific enzyme ...
Serena Giannelli, Francesca Eroli, Raúl Loera-Valencia, Valerio Leoni, Maria Latorre-Leal, Gabriella Testa, Erica Staurenghi, Barbara Sottero, Paola Gamba, Silvia Maioli, Gabriella Leonarduzzi   +10 more
doaj   +1 more source

Effects of Complete and Partial Loss of the 24S-Hydroxycholesterol-Generating Enzyme Cyp46a1 on Behavior and Hippocampal Transcription in Mouse

Biomolecules
Brain cholesterol metabolic products include neurosteroids and oxysterols, which play important roles in cellular physiology. In neurons, the cholesterol oxidation product, 24S-hydroxycholesterol (24S-HC), is a regulator of signaling and transcription ...
Hong-Jin Shu, Luke H. Ziolkowski, Sofia V. Salvatore, Ann M. Benz, David F. Wozniak, Carla M. Yuede, Steven M. Paul, Charles F. Zorumski, Steven Mennerick   +8 more
doaj   +1 more source

ABCA2 is a strong genetic risk factor for early-onset Alzheimer's disease

Neurobiology of Disease, 2005
Recent epidemiological, biological and genetic data indicate a relationship between cholesterol and Alzheimer's disease (AD) including the association of polymorphisms of ABCA1 (a gene that is known to participate in cholesterol and phospholipid ...
Sandrine Macé, Emmanuelle Cousin, Sylvain Ricard, Emmanuelle Génin, Emmanuel Spanakis, Carole Lafargue-Soubigou, Bérengère Génin, Raphaël Fournel, Sandrine Roche, Gilles Haussy, Florence Massey, Stéphane Soubigou, Georges Bréfort, Patrick Benoit, Alexis Brice, Dominique Campion, Melvyn Hollis, Laurent Pradier, Jésus Benavides, Jean-François Deleuze   +19 more
doaj   +1 more source

Cholesterol 25-hydroxylation activity of CYP3A

Journal of Lipid Research, 2011
To date, many studies have been conducted using 25-hydroxycholesterol, which is a potent regulator of lipid metabolism. However, the origins of this oxysterol have not been entirely elucidated. Cholesterol 25-hydroxylase is one of the enzymes responsible
Akira Honda, Teruo Miyazaki, Tadashi Ikegami, Junichi Iwamoto, Tomomi Maeda, Takeshi Hirayama, Yoshifumi Saito, Tamio Teramoto, Yasushi Matsuzaki   +8 more
doaj   +1 more source

Studies on the Transcriptional Regulation of Cholesterol 24-Hydroxylase (CYP46A1) [PDF]

Journal of Biological Chemistry, 2006
Yoshihiko Ohyama, Steve Meaney, Maura Heverin, Lena Ekström, Anat Brafman, Millicent Shafir, Ulla Andersson, Maria Olin, Gösta Eggertsen, Ulf Diczfalusy, Elena Feinstein, Ingemar Björkhem   +11 more
openaire   +1 more source