Results 71 to 80 of about 2,697 (198)

Repeated Intake of Grapefruit Juice Inhibits CYP2B6, CYP2C9, CYP2C19, and CYP3A4 while Lingonberry Powder Does Not Induce Major CYP Enzymes in Humans

Clinical Pharmacology &Therapeutics, Volume 119, Issue 4, Page 953-963, April 2026.
Grapefruit juice is a well‐established inhibitor of cytochrome P450 (CYP) 3A4, but its effects on other CYP enzymes or organic anion transporting polypeptides (OATPs) are not fully characterized in humans. Recently, lingonberry powder was shown to induce murine CYP enzymes. We investigated the effects of lingonberry powder and grapefruit juice on seven
Laura Aurinsalo, Outi Lapatto‐Reiniluoto, Mika Kurkela, Mikko Neuvonen, Eeva Moilanen, Mikko Niemi, Aleksi Tornio, Janne T. Backman   +7 more
wiley   +1 more source

Lipid peroxidation biomarkers for evaluating oxidative stress in equine neuroaxonal dystrophy. [PDF]

, 2018
BackgroundEquine neuroaxonal dystrophy/equine degenerative myeloencephalopathy (eNAD/EDM) is a neurodegenerative disorder affecting genetically predisposed foals maintained on an α-tocopherol (α-TOH) deficient diet.
Bordbari, Matthew H, Burns, Erin N, Estell, Krista E, Finno, Carrie J, Katzman, Scott, Miller, Andrew D, Puschner, Birgit, Tran, Cecilia K, Winfield, Laramie, Xu, Libin   +9 more
core  

Primary open-angle glaucoma: association with cholesterol 24S-hydroxylase (CYP46A1) gene polymorphism and plasma 24-hydroxycholesterol levels

, 2009
Purpose. Genetics has made significant contributions to the study of glaucoma over the past few decades. Cholesterol-24S-hydroxylase (CYP46A1) is a cholesterol-metabolizing enzyme that is especially expressed in retinal ganglion cells.
Acar, Niyazi, Björkhem, Ingemar, Bron, Alain, Brétillon, Lionel, Creuzot Garcher, Catherine, Diczfalusy, Ulf, Fourgeux, Cynthia, Joffre, Corinne, Martine, Lucy   +8 more
core   +3 more sources

The major brain cholesterol metabolite 24(s)-hydroxycholesterol is a potent allosteric modulator of N-methyl-d-aspartate receptors [PDF]

, 2013
N-methyl-d-aspartate receptors (NMDARs) are glutamate-gated ion channels that are critical to the regulation of excitatory synaptic function in the CNS.
Belfort, Gabriel M, Chow, Brian Y, Crawford, Devon C, Doherty, James J, Hammond, Rebecca S, Izumi, Yukitoshi, Linsenbardt, Andrew J, Mennerick, Steven J, Paul, Steven M, Robichaud, Albert J, Shu, Hong-Jin, Zorumski, Charles F   +11 more
core   +2 more sources

CYP46A1 inhibition, brain cholesterol accumulation and neurodegeneration pave the way for Alzheimer’s disease [PDF]

Brain, 2015
Abnormalities in neuronal cholesterol homeostasis have been suspected or observed in several neurodegenerative disorders including Alzheimer's disease, Parkinson's disease and Huntington's disease. However, it has not been demonstrated whether an increased abundance of cholesterol in neurons in vivo contributes to neurodegeneration.
Ayciriex, Sophie, Djelti, Fathia, Braudeau, Jérome, Hudry, Eloise, Dhenain, Marc, Varin, Jennifer, Bieche, Ivan, Marquer, Catherine, Chali, Farah, Auzeil, Nicolas, Alves, Sandro, Langui, Dominique, Potier, Marie-Claude, Laprévote, Olivier, Vidaud, Michel, Duyckaerts, Charles, Miles, Richard, Aubourg, Patrick, Cartier, Nathalie   +18 more
openaire   +2 more sources

Methylome-wide association study of different responses to risperidone in schizophrenia

Frontiers in Pharmacology, 2022
Background: Accumulating evidence shows that DNA methylation plays a role in antipsychotic response. However, the mechanisms by which DNA methylation changes are associated with antipsychotic responses remain largely unknown.Methods: We performed a ...
Huihui Du, Jingsong Ma, Jingsong Ma, Wei Zhou, Mo Li, Cong Huai, Lu Shen, Hao Wu, Xianglong Zhao, Na Zhang, Songyin Gao, Qi Wang, Lin He, Xuming Wu, Shengying Qin, Mingzhe Zhao, Mingzhe Zhao   +16 more
doaj   +1 more source

Reduction of the Cholesterol Sensor SCAP in the Brains of Mice Causes Impaired Synaptic Transmission and Altered Cognitive Function [PDF]

, 2013
The sterol sensor SCAP is a key regulator of SREBP-2, the major transcription factor controlling cholesterol synthesis. Recently, we showed that there is a global down-regulation of cholesterol synthetic genes, as well as SREBP-2, in the brains of ...
Chee, Melissa, Ferris, Heather, Kahn, C. Ronald, Maratos-Flier, Eleftheria, Suzuki, Ryo   +4 more
core   +3 more sources

Structural Basis of Drug Binding to CYP46A1, an Enzyme That Controls Cholesterol Turnover in the Brain [PDF]

Journal of Biological Chemistry, 2010
Cytochrome P450 46A1 (CYP46A1) initiates the major pathway of cholesterol elimination from the brain and thereby controls cholesterol turnover in this organ. We determined x-ray crystal structures of CYP46A1 in complex with four structurally distinct pharmaceuticals; antidepressant tranylcypromine (2.15 Å), anticonvulsant thioperamide (1.65 Å ...
Natalia, Mast, Casey, Charvet, Irina A, Pikuleva, C David, Stout   +3 more
openaire   +2 more sources

Unilateral mastication‐induced memory deficits linked to disrupted hippocampal cholesterol metabolism in rats

VIEW, Volume 7, Issue 2, April 2026.
Unilateral mastication, a common oral habit, induces cognitive decline in rats by disrupting hippocampal cholesterol metabolism. It triggers astrocyte hyperplasia, enhances cholesterol synthesis, impairs transport/degradation, and reduces 24‐hydroxycholesterol (24‐OHC), ultimately damaging synaptic function.
Xiaoting Zhai, Yifan Hu, Rongchen Xu, Xinyu Xu, Bowen Ma, Dongzong Huang, Hongchen Liu, Hongbo Li, Yuan Hu, Hua Jiang   +9 more
wiley   +1 more source

HDL inhibits endoplasmic reticulum stress-induced apoptosis of pancreatic β-cells in vitro by activation of Smoothened[S]

Journal of Lipid Research, 2020
Loss of pancreatic β-cell mass and function as a result of sustained ER stress is a core step in the pathogenesis of diabetes mellitus type 2. The complex control of β-cells and insulin production involves hedgehog (Hh) signaling pathways as well as ...
Mustafa Yalcinkaya, Anja Kerksiek, Katrin Gebert, Wijtske Annema, Rahel Sibler, Silvija Radosavljevic, Dieter Lütjohann, Lucia Rohrer, Arnold von Eckardstein   +8 more
doaj   +1 more source