Results 71 to 80 of about 1,942 (152)

Navigating the cholesterol maze: Key insights on use of statins in neurodegenerative disorders

Neuroprotection, Volume 4, Issue 1, Page 30-47, March 2026.
The graphical abstract encapsulates the dual neuroprotective mechanisms of statins in neurodegenerative diseases, highlighting both cholesterol‐dependent and cholesterol‐independent pathways. By inhibiting 3‐hydroxy‐3‐methylglutaryl coenzyme A (HMG‐CoA) reductase, statins reduce cholesterol synthesis, leading to altered lipid raft structures that ...
Jun Han Kuan, Roshan S. Raghavan, Dawn Li Wei Koh, Wing Yeng Tan, Igor Iezhitsa, Renu Agarwal   +5 more
wiley   +1 more source

Bile Acids as Key Mediators of the Gut Microbiota–Immune Axis: Potential Biomarker and Therapeutic Perspectives

BioFactors, Volume 52, Issue 1, January/February 2026.
Primary bile acids synthesized in the liver are transformed by gut microbes into secondary bile acids that engage receptors such as FXR and TGR5, thereby modulating immune function and metabolic homeostasis. Dysregulation of these signaling pathways contributes to MASH, NAFLD, IBD, and neurodegenerative disorders, underscoring their relevance as ...
Simone Baldi, Margherita Turrini, Francesco Cei, Marta Menicatti, Gianluca Bartolucci, Amedeo Amedei   +5 more
wiley   +1 more source

Transcriptional regulation of the human CYP46A1 brain-specific expression by Sp transcription factors

, 2008
Brain defective cholesterol homeostasis has been associated with neurologic diseases, such as Alzheimer's and Huntington's disease. The elimination of cholesterol from the brain involves its conversion into 24(S)-hydroxycholesterol by CYP46A1, and the ...
Lechner, M. C., Nunes, M. J., Pascussi, JM, Gama, MJ, Milagre, I., Pascussi, J. M., Milagre, I, Silva, R. F., Nunes, MJ, Rodrigues, E, Lechner, MC, Gama, M. J., Rodrigues, E., Silva, RF   +13 more
core   +1 more source

CYP46A1-mediated cholesterol turnover induces sex-specific changes in cognition and counteracts memory loss in ovariectomized mice [PDF]

The brain-specific enzyme CYP46A1 controls cholesterol turnover by converting cholesterol into 24S-hydroxycholesterol (24OH). Dysregulation of brain cholesterol turnover and reduced CYP46A1 levels are observed in Alzheimer's disease (AD).
Matton, Anna, Blennow, Kaj,, Eroli, Francesca, Franchini, Luca, Pacciarini, Manuela, Björkhem, Ingemar, Maioli, Silvia, Zetterberg, Henrik,, Winblad, Bengt, Kivipelto, Miia, Varshney, Mukesh K., Nikolidakis, Orestis, Cedazo-Minguez, Angel, Rodriguez-Rodriguez, Patricia, Merino-Serrais, Paula, Wang, Yuqin, Griffiths, William J., Nalvarte, Ivan, Delac, Ljerka, Daniilidou, Makrina, Latorre-Leal, María, Arroyo-García, Luis E.   +21 more
core   +2 more sources

Effects of Complete and Partial Loss of the 24S-Hydroxycholesterol-Generating Enzyme Cyp46a1 on Behavior and Hippocampal Transcription in Mouse

Biomolecules
Brain cholesterol metabolic products include neurosteroids and oxysterols, which play important roles in cellular physiology. In neurons, the cholesterol oxidation product, 24S-hydroxycholesterol (24S-HC), is a regulator of signaling and transcription ...
Hong-Jin Shu, Luke H. Ziolkowski, Sofia V. Salvatore, Ann M. Benz, David F. Wozniak, Carla M. Yuede, Steven M. Paul, Charles F. Zorumski, Steven Mennerick   +8 more
doaj   +1 more source

ABCA2 is a strong genetic risk factor for early-onset Alzheimer's disease

Neurobiology of Disease, 2005
Recent epidemiological, biological and genetic data indicate a relationship between cholesterol and Alzheimer's disease (AD) including the association of polymorphisms of ABCA1 (a gene that is known to participate in cholesterol and phospholipid ...
Sandrine Macé, Emmanuelle Cousin, Sylvain Ricard, Emmanuelle Génin, Emmanuel Spanakis, Carole Lafargue-Soubigou, Bérengère Génin, Raphaël Fournel, Sandrine Roche, Gilles Haussy, Florence Massey, Stéphane Soubigou, Georges Bréfort, Patrick Benoit, Alexis Brice, Dominique Campion, Melvyn Hollis, Laurent Pradier, Jésus Benavides, Jean-François Deleuze   +19 more
doaj   +1 more source

Levels of presynaptic proteins were increased in the hippocampus of CYP46A1 mice.

, 2013
Hippocampal samples from CYP46A1 and WT control mice were analyzed by Western blotting. Synapthophysin and synapsin-1 levels were significantly increased in CYP46A1 mice, while no differences were found in Neun among the groups.
Ann Båvner (9780), Zeina Ali (430169), Muhammad-Al-Mustafa Ismail (434119), Elena Puerta (434120), Silvia Maioli (434118), Maria Olin (430168), Ahmed Saeed (434121), Angel Cedazo-Minguez (5655541), Maura Heverin (430170), Marjan Shafaati (434122), Paolo Parini (87438), Ingemar Björkhem (430172)   +11 more
core   +1 more source

Molecular Pathology Insights into ALS Susceptibility: Exploratory Association of CYP46A1 rs754203 in Brazilian Case–Control Study

Journal of Molecular Pathology
Background/Objectives: Amyotrophic lateral sclerosis (ALS) is a complex neurodegenerative disease, and alterations in cholesterol metabolism may contribute to motor neuron vulnerability.
Angela Adamski da Silva Reis, Caroline Christine Pincela da Costa, Diolina Gonçalves da Silva, Nayane Soares de Lima, Rodrigo da Silva Santos   +4 more
doaj   +1 more source

Cholesterol 25-hydroxylation activity of CYP3A

Journal of Lipid Research, 2011
To date, many studies have been conducted using 25-hydroxycholesterol, which is a potent regulator of lipid metabolism. However, the origins of this oxysterol have not been entirely elucidated. Cholesterol 25-hydroxylase is one of the enzymes responsible
Akira Honda, Teruo Miyazaki, Tadashi Ikegami, Junichi Iwamoto, Tomomi Maeda, Takeshi Hirayama, Yoshifumi Saito, Tamio Teramoto, Yasushi Matsuzaki   +8 more
doaj   +1 more source

Cholesterol and oxysterols in retinal neuron-glia interactions: relevance for glaucoma

Frontiers in Ophthalmology
Cholesterol is an essential component of cellular membranes, crucial for maintaining their structural and functional integrity. It is especially important for nervous tissues, including the retina, which rely on high amounts of plasma membranes for the ...
Elodie A.Y. Masson, Jeanne Serrano, Jeanne Serrano, Elise Leger-Charnay, Niyazi Acar   +4 more
doaj   +1 more source