Results 81 to 90 of about 1,942 (152)

Is it possible to improve memory function by upregulation of the cholesterol 24S-hydroxylase (CYP46A1) in the brain? PLoS One [PDF]

, 2013
We previously described a heterozygous mouse model overexpressing human HA-tagged 24S-hydroxylase (CYP46A1) utilizing a ubiquitous expression vector. In this study, we generated homozygotes of these mice with circulating levels of 24OH 30-60% higher than
Zeina Ali, Muhammad-Al-Mustafa Ismail, *, Maria Olin, Angel Cedazo-Minguez, Ann Båvner, Ahmed Saeed, Ingemar Bjö Rkhem, Maura Heverin, Elena Puerta, Marjan Shafaati, Silvia Maioli, Paolo Parini   +12 more
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Construction and verification of an endoplasmic reticulum stress-related prognostic model for endometrial cancer based on WGCNA and machine learning algorithms

Frontiers in Oncology
BackgroundEndoplasmic reticulum (ER) stress arises from the accumulation of misfolded or unfolded proteins within the cell and is intricately linked to the initiation and progression of various tumors and their therapeutic strategies.
Shanshan Lin, Changqiang Wei, Yiyun Wei, Jiangtao Fan   +3 more
doaj   +1 more source

24S-hydroxycholesterol and cholesterol-24S-hydroxylase (CYP46A1) in the retina: from cholesterol homeostasis to pathophysiology of glaucoma.

, 2011
http://www.sciencedirect.com/International audienceFree cholesterol is the predominant form of cholesterol in the neural retina. The vertebrate neural retina exhibits its own capacity to synthesize cholesterol and meets its demand also by taking it from ...
Brétillon, Lionel, Creuzot-Garcher, Catherine, Bron, Alain, Lionel Bretillon, Acar, Niyazi, Catherine Creuzot-Garcher, Cynthia Fourgeux, Alain Bron, Niyazi Acar, Fourgeux, Cynthia   +9 more
core   +1 more source

Salinity modulates gut microbiota and host transcriptome dynamics in juvenile euryhaline fish yellowfin seabream (Acanthopagrus latus)

Aquaculture Reports
Salinity critically modulates physiological adaptations in aquatic animals, particularly in euryhaline species frequently encountering salinity fluctuations. Here, we investigated how environmental salinity (10 ppt vs.
Cheng Peng, Huayi Xue, Jingjing Zhang, Jin Zhang, Jiage Dai, Yong Zhang, Shijia Hu   +6 more
doaj   +1 more source

CYP46A1 at the Crosstalk Between Autophagy and Oxidative Stress in Niemann-Pick type C disease

A doença de Niemann-Pick tipo C (NPC) é caraterizada pela acumulação de colesterol não esterificado e outros lípidos nos endossomas/ lisossomas tardios. A disfunção na homeostasia do colesterol resulta num fenótipo metabólico e neurodegeneração, devido à
Nunes, Sofia Alexandra Gomes
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Exploring Whether Biological Sex Impacts the Effects of CYP46A1 Overexpression in a Mouse Model of Alzheimer's Disease

The overexpression of cholesterol 24-hydroxylase (CYP46A1), an enzyme crucial for cholesterol turnover in the brain, has recently been explored as a potential therapeutic strategy for Alzheimer's disease (AD), given the linkage between cholesterol ...
Inês Beatriz da Costa Moreira
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Cholesterol-24S-hydroxylase (CYP46A1) and cholesterol homeostasis in the retina in physiological and pathological conditions

, 2012
Le cholestérol est le principal stérol présent dans la rétine. Dans sa forme libre, le cholestérol est distribué dans toutes les couches cellulaires de la rétine, alors que le cholestérol estérifié s’accumule essentiellement à la base de l’épithélium ...
Fourgeux, Cynthia
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In vivo consequences of cholesterol-24s-hydroxylase (CYP46A1) inhibition by voriconazole on cholesterol homeostasis and function in the rat retina

, 2011
Cholesterol 24S-hydroxylase (CYP46A1) converts cholesterol into 24S-hydroxycholesterol in neurons and participates in cholesterol homeostasis in the central nervous system, including the retina. We aimed to evaluate the consequences of CYP46A1 inhibition
Pasquis, Bruno, Brétillon, Lionel, Martine, Lucy, Creuzot-Garcher, Catherine, Bron, Alain, Acar, Niyazi, Fourgeux, Cynthia   +6 more
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Editorial: Cholesterol and Neurodegenerative Diseases - Pressing Questions and How to Address Them

Frontiers in Aging Neuroscience, 2022
Sandrine Betuing, Sandrine Betuing, Sandrine Betuing, Irina A. Pikuleva, Joseph M. Castellano   +4 more
doaj   +1 more source

Rôle de la cholestérol hydroxylase CYP46A1 dans le métabolisme du cholestérol et les mécanismes de neuroprotection dans la maladie de Huntington

, 2019
La maladie de Huntington (MH) est une maladie génétique autosomique dominante, causée par une augmentation du nombre de CAG sur le gène de la huntingtin. L’homéostasie du cholestérol cérébral est altérée dans la MH.
Kacher, Radhia
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