Results 81 to 90 of about 2,697 (198)
Cholesterol homeostasis: a key to prevent or slow down neurodegeneration [PDF]
, 2013 Neurodegeneration, a common feature for many brain disorders, has severe consequences on the mental and physical health of an individual. Typically human neurodegenerative diseases are devastating illnesses that predominantly affect elderly people ...
Anchisi L., Dessi S., Mandas A, Pani A.
core +1 more source
Navigating the cholesterol maze: Key insights on use of statins in neurodegenerative disorders
Neuroprotection, Volume 4, Issue 1, Page 30-47, March 2026.The graphical abstract encapsulates the dual neuroprotective mechanisms of statins in neurodegenerative diseases, highlighting both cholesterol‐dependent and cholesterol‐independent pathways. By inhibiting 3‐hydroxy‐3‐methylglutaryl coenzyme A (HMG‐CoA) reductase, statins reduce cholesterol synthesis, leading to altered lipid raft structures that ...
Jun Han Kuan +5 more
wiley +1 more source
Cellular and Molecular Gastroenterology and Hepatology, 2018 Hepatic encephalopathy is a serious neurologic complication of acute and chronic liver diseases. We previously showed that aberrant bile acid signaling contributes to the development of hepatic encephalopathy via farnesoid X receptor (FXR)-mediated ...
Matthew McMillin +8 more
doaj +1 more source
24s-Hydroxycholesterol. Studies on regulatory mechanisms behind its formation in the brain and its potential use as a marker for neurodegeneration [PDF]
, 2010 Cholesterol 24-hydroxylase (CYP46A1) belongs to the cytochrome P450 super family and is responsible for conversion of cholesterol to the oxysterol 24S- hydroxycholesterol (24S-OHC).
Shafaati, Marjan
core
Analysis of gene regulatory networks of maize in response to nitrogen [PDF]
, 2018 Nitrogen (N) fertilizer has a major influence on the yield and quality. Understanding and optimising the response of crop plants to nitrogen fertilizer usage is of central importance in enhancing food security and agricultural sustainability.
Anne Coules +9 more
core +2 more sources
BioFactors, Volume 52, Issue 1, January/February 2026.Primary bile acids synthesized in the liver are transformed by gut microbes into secondary bile acids that engage receptors such as FXR and TGR5, thereby modulating immune function and metabolic homeostasis. Dysregulation of these signaling pathways contributes to MASH, NAFLD, IBD, and neurodegenerative disorders, underscoring their relevance as ...
Simone Baldi +5 more
wiley +1 more source
Deletion of TSPO Causes Dysregulation of Cholesterol Metabolism in Mouse Retina
Cells, 2021 Cholesterol dysregulation has been implicated in age-related macular degeneration (AMD), the most common cause of visual impairment in the elderly.
Fahad Farhan +7 more
doaj +1 more source
Role of Cholesterol Metabolic Enzyme CYP46A1 and Its Metabolite 24S-Hydroxycholesterol in Ischemic Stroke. [PDF]
StrokeBACKGROUND: For several decades, it has been recognized that overactivation of the glutamate-gated N-methyl-D-aspartate receptors (NMDARs) and subsequent Ca 2+ toxicity play a critical role in ischemic brain injury.
Sun H +4 more
europepmc +4 more sources
A study on the association of the chromosome 12p13 locus with sporadic late-onset alzheimer's disease in Chinese [PDF]
, 2009 Recent linkage and association studies have implicated the chromosome 12p13 locus as possibly harboring genetic variants predisposed to Alzheimer's disease (AD).
Chu, LW, Li, Y, Li, Z, Song, YQ, Yik, PY
core +1 more source
Scientific Reports, 2017 Increased evidence suggests that dysregulation of cholesterol metabolism may be a key event contributing to progression of multiple sclerosis (MS). Using an experimental autoimmune encephalomyelitis (EAE) model of MS we revealed specific changes in the ...
Irena Lavrnja +6 more
doaj +1 more source