Results 101 to 110 of about 2,697 (198)

Mapping of the Allosteric Site in Cholesterol Hydroxylase CYP46A1 for Efavirenz, a Drug That Stimulates Enzyme Activity [PDF]

Journal of Biological Chemistry, 2016
Cytochrome P450 46A1 (CYP46A1) is a microsomal enzyme and cholesterol 24-hydroxylase that controls cholesterol elimination from the brain. This P450 is also a potential target for Alzheimer disease because it can be activated pharmacologically by some marketed drugs, as exemplified by efavirenz, the anti-HIV medication.
Kyle W, Anderson, Natalia, Mast, Jeffrey W, Hudgens, Joseph B, Lin, Illarion V, Turko, Irina A, Pikuleva   +5 more
openaire   +2 more sources

Treatment of Inborn Errors by Product Replacement: The Example of Inborn Errors of Bile Acid Synthesis

Journal of Inherited Metabolic Disease, Volume 48, Issue 5, September 2025.
ABSTRACT Many inborn errors of metabolism affect pathways involved in the synthesis of a metabolite that has an important biochemical or physiological function, and adverse effects of the disorder can be attributed to the lack of this metabolite. Thus, there is the opportunity for treatment by ‘product replacement’. One of the disorders in the pathways
Peter T. Clayton, Rohit Hirachan, Elaine Murphy   +2 more
wiley   +1 more source

Elevated 24-hydroxycholesterol levels counteract okadaic acid-induced tau hyperphosphorylation and neuronal morphology impairment

Neurobiology of Disease
Multiple findings underline a link between altered brain cholesterol metabolism and Alzheimer's disease (AD) pathogenesis. Physiologically, excess brain cholesterol is mainly converted into 24-hydroxycholesterol (24-OHC) by the neuron-specific enzyme ...
Serena Giannelli, Francesca Eroli, Raúl Loera-Valencia, Valerio Leoni, Maria Latorre-Leal, Gabriella Testa, Erica Staurenghi, Barbara Sottero, Paola Gamba, Silvia Maioli, Gabriella Leonarduzzi   +10 more
doaj   +1 more source

Implications of cholesterol and cholesterol-lowering therapy in Alzheimer s disease [PDF]

, 2007
BACKGROUND: Alzheimer s disease (AD) is a severe neurodegenerative disease that mainly afflicts elderly persons, with a characteristic progressive decline of cognitive functions and dementia.
Famer, Daniel
core  

Pathway-Wide Association Study Implicates Multiple Sterol Transport and Metabolism Genes in HDL Cholesterol Regulation [PDF]

, 2011
Pathway-based association methods have been proposed to be an effective approach in identifying disease genes, when single-marker association tests do not have sufficient power.
Kai eWang, Kai eWang, Andrew C Edmondson, Andrew C Edmondson, Mingyao eLi, Fan eGao, Atif N Qasim, Joseph M Devaney, Mary Susan eBurnett, Dawn M Waterworth, Vincent eMooser, Struan F.A. Grant, Struan F.A. Grant, Stephen E Epstein, Muredach P Reilly, Hakon eHakonarson, Hakon eHakonarson, Daniel J Rader, Daniel J Rader   +18 more
core   +1 more source

Implications for soluble iron accumulation, oxidative stress, and glial glutamate release in motor neuron death associated with sporadic amyotrophic lateral sclerosis

Neuropathology, Volume 45, Issue 3, Page 177-201, June 2025.
Oxidative stress in sporadic amyotrophic lateral sclerosis (ALS) has been evidenced by accumulation of oxidatively modified products of nucleic acids, lipids, sugars, and proteins in the motor neuron system of brains and spinal cords obtained at autopsy from the patients.
Noriyuki Shibata, Ikuko Kataoka, Yukinori Okamura, Kumiko Murakami, Yoichiro Kato, Tomoko Yamamoto, Kenta Masui   +6 more
wiley   +1 more source

Context-dependent compensation among phosphatidylserine-recognition receptors [PDF]

, 2017
Phagocytes express multiple phosphatidylserine (PtdSer) receptors that recognize apoptotic cells. It is unknown whether these receptors are interchangeable or if they play unique roles during cell clearance.
Han, Claudia Z, Lee, Chang Sup, Lysiak, Jeffrey J, Onengut-Gumuscu, Suna, Palczewski, Krzysztof, Penberthy, Kristen K, Perry, Justin SA, Ravichandran, Kodi, Raymond, Michael H, Rival, Claudia, Shankman, Laura S, Zhang, Jianye   +11 more
core   +3 more sources

Successful therapies for Alzheimer's disease: why so many in animal models and none in humans? [PDF]

, 2015
Peering into the field of Alzheimer's disease (AD), the outsider realizes that many of the therapeutic strategies tested (in animal models) have been successful.
Cedazo-Mínguez, Ángel, Franco Fernández, Rafael   +1 more
core   +2 more sources

Cholesterol‐27α‐hydroxylase inhibitor nilvadipine can effectively treat cholestatic liver injury in adult offspring induced by prenatal dexamethasone exposure

MedComm, Volume 6, Issue 3, March 2025.
Dexamethasone enhanced CYP27A1 promoter H3K14ac level and expression through the GR/miR‐450b‐3p/SIRT1 pathway during pregnancy. The elevated CYP27A1 persists until birth, which elevates primary unconjugated bile acids and endoplasmic reticulum stress, causing cholestatic liver injury in adult female offspring. CYP27A1 and nilvadipine are first proposed
Wen Hu, Jiayong Zhu, Qi Zhang, Xiaoqian Lu, Luting Yu, Bin Li, Liaobin Chen, Hui Wang   +7 more
wiley   +1 more source

27-Hydroxycholesterol Promotes the Transfer of Astrocyte-Derived Cholesterol to Neurons in Co-cultured SH-SY5Y Cells and C6 Cells

Frontiers in Cell and Developmental Biology, 2020
Abnormality in cholesterol homeostasis in the brain is a feature of Alzheimer’s disease (AD). 27-Hydroxycholesterol (27-OHC) has been identified as a possible biomarker of AD, but its effects on cholesterol metabolism have not been fully characterized ...
Yushan Wang, Xiaona Zhang, Tao Wang, Wen Liu, Lijing Wang, Ling Hao, Mengwei Ju, Rong Xiao   +7 more
doaj   +1 more source