Results 121 to 130 of about 2,697 (198)

Cholesterol and oxysterols in retinal neuron-glia interactions: relevance for glaucoma

Frontiers in Ophthalmology
Cholesterol is an essential component of cellular membranes, crucial for maintaining their structural and functional integrity. It is especially important for nervous tissues, including the retina, which rely on high amounts of plasma membranes for the ...
Elodie A.Y. Masson, Jeanne Serrano, Jeanne Serrano, Elise Leger-Charnay, Niyazi Acar   +4 more
doaj   +1 more source

The Evolution of Cholesterol-Rich Membrane in Oxygen Adaption: The Respiratory System as a Model. [PDF]

, 2019
The increase in atmospheric oxygen levels imposed significant environmental pressure on primitive organisms concerning intracellular oxygen concentration management.
Patel, Hemal H, Zuniga-Hertz, Juan Pablo
core   +1 more source

Retinal pigment epithelium cholesterol efflux mediated by the 18kDa translocator protein, TSPO, a potential target for treating age-related macular degeneration [PDF]

, 2017
Biswas, Lincoln, Dhillon, Baljean, Graham, Annette, Shu, Xinhua, Zhou, Xinzhi   +4 more
core   +2 more sources

CYP46A1 Activation Improves Retinal Neovascularization in a Mouse Model of Retinopathy of Prematurity

Abstract Previous studies have shown the metabolic and regulatory significance of CYP46A1 in the adult retina; however, its role in the developing retina is unknown. Here, we evaluate CYP46A1 expression and the impact of its activation in the developing mouse retina under normal and pathological conditions.
Bailey, Briah, Zhong Manis, Josephine Rudd, Seth, Gayatri, Rajpurohit, Shubhra, Oxenrider, Allston, Martin, Pamela M., Jadeja, Ravirajsinh N., Thounaojam, Menaka C.   +7 more
openaire   +2 more sources

Salinity modulates gut microbiota and host transcriptome dynamics in juvenile euryhaline fish yellowfin seabream (Acanthopagrus latus)

Aquaculture Reports
Salinity critically modulates physiological adaptations in aquatic animals, particularly in euryhaline species frequently encountering salinity fluctuations. Here, we investigated how environmental salinity (10 ppt vs.
Cheng Peng, Huayi Xue, Jingjing Zhang, Jin Zhang, Jiage Dai, Yong Zhang, Shijia Hu   +6 more
doaj   +1 more source

RETRACTED ARTICLE: Age-dependent Increase in Desmosterol Restores DRM Formation and Membrane-related Functions in Cholesterol-free DHCR24−/− Mice [PDF]

, 2018
Cholesterol is a prominent modulator of the integrity and functional activity of physiological membranes and the most abundant sterol in the mammalian brain. DHCR24-knock-out mice lack cholesterol and accumulate desmosterol with age.
Crameri, Arames, Heppner, Frank, Kalvodova, Lucie, Kuehnle, Katrin, Kulic, Luka, Ledesma, Maria, Lütjohann, Dieter, Mohajeri, M., Nitsch, Roger, Skaanes-Brunner, Fabienne, Smith, Alicia, Thelen, Karin   +11 more
core  

Quantitative Determination of Cholesterol Hydroxylase Specificities by GC–MS/MS in Living Mammalian Cells

Bio-Protocol
Cholesterol is oxygenated by a variety of cholesterol hydroxylases; oxysterols play diverse important roles in physiological and pathophysiological conditions by regulating several transcription factors and cell-surface receptors.
Hodaka Saito, Mizuki Nishimura, Ryuichiro Sato, Yoshio Yamauchi   +3 more
doaj   +1 more source

Editorial: Cholesterol and Neurodegenerative Diseases - Pressing Questions and How to Address Them

Frontiers in Aging Neuroscience, 2022
Sandrine Betuing, Sandrine Betuing, Sandrine Betuing, Irina A. Pikuleva, Joseph M. Castellano   +4 more
doaj   +1 more source

Simultaneous inferences based on empirical Bayes methods and false discovery rates ineQTL data analysis [PDF]

, 2013

core   +1 more source

Radiosynthesis and Evaluation of ¹⁸F‑Labeled Deuterated Radioligand for Positron Emission Tomography Imaging of Cholesterol 24-Hydroxylase. [PDF]

ACS Med Chem Lett
Li Y, Song Z, Shi H, Zhao T, Chen J, Zhou X, Hu Q, Li X, Meng L, Song R, Sun Z, Li C, Haider A, Yuan H, Liang SH.   +14 more
europepmc   +1 more source