Results 121 to 130 of about 1,473 (145)

Hypothalamic CYP46A1 cholesterol metabolism regulates diet-induced obesity

Abstract Obesity is a growing global health challenge which affects over 38% of the population and increases the risk of developing metabolic disorders. Effective long-term treatment options remain limited and often lead to significant side effects.
David V.C. Brito, Adriana Arrulo Pereira, Renata Sandres de Souza Araujo, Bruno André Martins Várzea, Xavier Guerreiro Anastácio, Telma Cristina Aureliano Castro, Célia Aveleira, Sara Carmo-Silva, Marisa Ferreira-Marques, Ana Luísa Sousa-Coelho, José Matos, Leonor Faleiro, Nathalie Cartier, Sandro Alves, Clévio Nóbrega   +14 more
openaire   +1 more source

P699. Association Between CYP46A1 rs754203 Polymorphism and Completed Suicide

Biological Psychiatry, 2022
Maria Fernanda Serna, Ricardo M. Serna-Flores, Alfonso Ontiveros, Mario Alberto Hernandez-Ordoñez, Antonio Ali Perez-Maya   +4 more
openaire   +1 more source

Cell-Type Specific Regulation of Cholesterogenesis by CYP46A1 Re-Expression in zQ175 HD Mouse Striatum

International Journal of Molecular Sciences, 2023
Coline Mounier, Jean-François Gilles, Peter Vanhoutte   +2 more
exaly  

Therapeutic implications of altered cholesterol homeostasis mediated by loss of CYP46A1 in human glioblastoma

EMBO Molecular Medicine, 2020
Mingzhi Han, Shuai Wang, Ning Yang
exaly  

Brain Acetyl-CoA Production and Phosphorylation of Cytoskeletal Proteins Are Targets of CYP46A1 Activity Modulation and Altered Sterol Flux

Neurotherapeutics, 2021
Natalia Mast, Alexey M Petrov, Erin Prendergast   +2 more
exaly  

Neuronal differentiation alters the ratio of Sp transcription factors recruited to the CYP46A1 promoter

Journal of Neurochemistry, 2012
Inés Milagre, Maria João Nunes, Margarida Castro-Caldas   +2 more
exaly  

Role of CYP46A1 in brain cholesterol homeostasis

2008
Rodrigues, E, Milagre, I, Nunes, MJ, Gama, MJ, Rodrigues, CMP   +4 more
openaire   +3 more sources

In vivo consequences of cholesterol-24S-hydroxylase (CYP46A1) inhibition by voriconazole on cholesterol homeostasis and function in the rat retina

Biochemical and Biophysical Research Communications, 2014
Cynthia Fourgeux, Lucy Martine, Niyazi Acar   +2 more
exaly  

Sp proteins play a critical role in histone deacetylase inhibitor‐mediated derepression of CYP46A1 gene transcription

Journal of Neurochemistry, 2010
Maria João Nunes, Inés Milagre, Michael Schnekenburger   +2 more
exaly  

CYP46A1 T/C polymorphism associated with the APOEε4 allele increases the risk of Alzheimer’s disease

Journal of Neurology, 2012
Gongbo Li, Hua-Dong Zhou, Wang Yanjiang   +2 more
exaly