Results 111 to 120 of about 1,473 (145)

The potential of CYP46A1 as a novel therapeutic target for neurological disorders: An updated review of mechanisms

European Journal of Pharmacology, 2023
Cholesterol is a key component of the cell membrane that impacts the permeability, fluidity, and functions of membrane-bound proteins. It also participates in synaptogenesis, synaptic function, axonal growth, dendrite outgrowth, and microtubule stability. Cholesterol biosynthesis and metabolism are in balance in the brain.
Mohaddeseh Sadat Alavi, Gholamreza Karimi, Hussein A Ghanimi   +2 more
exaly   +3 more sources

Metabolism of oral turinabol by the human brain cholesterol 24-hydroxylase CYP46A1

The Journal of Steroid Biochemistry and Molecular Biology, 2021
The human microsomal cytochrome P450 enzyme CYP46A1 plays a crucial role in cholesterol elimination from the brain. It performs a 24-hydroxylation of cholesterol and is of outstanding significance for memory and cognition. This study demonstrates the catalytic activity of human CYP46A1 towards an anabolic androgenic steroid, oral turinabol ...
Natalia Putkaradze, Philip Hartz, Michael C. Hutter, Josef Zapp, Mario Thevis, Rita Bernhardt   +5 more
openaire   +2 more sources

Cholesterol-24S-hydroxylase (CYP46A1) Is Specifically Expressed in Neurons of the Neural Retina

Current Eye Research, 2007
Increasing biological findings argue for the importance of cholesterol-24S-hydroxylase (CYP46A1) in cholesterol homeostasis in cerebral structures. Based on the similarity between the brain and the neural retina, the aim of the current study was to evaluate the expression of CYP46A1 in the mammalian retina.
Brétillon, Lionel, Diczfalusy, Ulf, Bjorkhem, Ingemar, Maire, Marie-Annick, Martine, Lucy, Joffre, Corinne, Acar, Niyazi, Bron, Alain, M., Creuzot Garcher, Catherine, Creuzot-Garcher, Catherine   +9 more
openaire   +4 more sources

The association between CYP46A1 rs4900442 polymorphism and the risk of Alzheimer’s disease: A meta-analysis

Neuroscience Letters, 2016
Polymorphisms in the CYP46A1 rs4900442 have been controversially associated with increased risk of developing Alzheimer's disease (AD). Therefore, a meta-analysis was performed to assess the possible association between CYP46A1 gene rs4900442 polymorphism and AD. A comprehensive search was conducted to identify all case-control or cohort design studies
Ning Song, Xixun Du, Junxia Xie
exaly   +3 more sources

$CYP46A1$ Functional Promoter Haplotypes Decipher Genetic Susceptibility to Alzheimer's Disease

Journal of Alzheimer's Disease, 2010
We here demonstrate that promoter polymorphisms rs8003602 and rs3783320 of cholesterol 24S-hydroxylase (CYP46A1) were significantly associated with Alzheimer's disease (AD) in Chinese subjects. Haplotype analyses showed that haplotype CG is the risk haplotype.
Li, Y, Song, YQ, Wang, B, Huriletemuer, Jin, DY, Ma, X, Chu, LW, Yik, PY   +7 more
openaire   +4 more sources

An Intronic CYP46A1 Polymorphism Is Associated with Alzheimer Disease in a Chinese Han Population

Journal of Molecular Neuroscience, 2012
Excess cholesterol is removed from the brain via hydroxylation mediated by cholesterol 24S-hydroxylase (CYP46), which is a mechanism of maintaining cholesterol homeostasis in the brain. The CYP46A1 gene has been suggested as a genetic risk factor for sporadic late-onset Alzheimer's disease (AD).
Xiao-ming, He, Zhen-xin, Zhang, Jun-Wu, Zhang, Yong-tao, Zhou, Cheng-bin, Wu, Mou-ni, Tang, Zhen, Hong   +6 more
openaire   +2 more sources

The Relationship Between CYP46A1 Polymorphism and Suicide Risk: A Preliminary Investigation

NeuroMolecular Medicine
Suicide is a global public health issue, with a particularly high incidence in individuals suffering from Major Depressive Disorder (MDD). The role of cholesterol in suicide risk remains controversial, prompting investigations into genetic markers that may be implicated.
María Fernanda, Serna-Rodríguez, Oscar, Cienfuegos-Jiménez, Ricardo Martín, Cerda-Flores, Iván Alberto, Marino-Martínez, Mario Alberto, Hernández-Ordoñez, José Alfonso, Ontiveros-Sánchez de la Barquera, Antonio Alí, Pérez-Maya   +6 more
openaire   +2 more sources

Cholesterol metabolism via cyp46a1 in glaucoma

2012
Cholesterol metabolism via cyp46a1 in glaucoma.
Brétillon, Lionel, Fourgeux, Cynthia, Acar, Niyazi, Creuzot-Garcher, Catherine, Bron, Alain   +4 more
openaire   +1 more source

Repression of the human CYP46A1 promoter by retinoic acid

2007
FCT, FEDER.
Milagre, I, Nunes, MJ, Gama, MJ, Pascussi, JM, Lechner, MC, Rodrigues, E   +5 more
openaire   +1 more source

ABCA1 AND CYP46A1 GENES VARIANTS ARE ASSOCIATED WITH SUICIDAL BEHAVIOR.

European Neuropsychopharmacology, 2022
Maria Fernanda Serna Rodriguez, Mario Alberto Hernández-Ordoñez, Iván Alberto Marino-Martínez, José Alfonso Ontiveros-Sánchez de la Barquera, Antonio Alí Pérez-Maya   +4 more
openaire   +1 more source