Results 131 to 140 of about 1,942 (152)

Biochemical, Molecular and Behavioral Changes Induced by High-fat and High-sugar Diets: A Systematic Review of Non-clinical Studies. [PDF]

Mol Neurobiol
Bach C, Souza JV, Oliveira CS, Mello RG, Maria-Ferreira D.   +4 more
europepmc   +1 more source

Cell-Type Specific Regulation of Cholesterogenesis by CYP46A1 Re-Expression in zQ175 HD Mouse Striatum

International Journal of Molecular Sciences, 2023
International audienceCholesterol metabolism dysregulation is associated with several neurological disorders. In Huntington’s disease (HD), several enzymes involved in cholesterol metabolism are downregulated, among which the neuronal cholesterol 24 ...
Peter VANHOUTTE, Jean-Francois Gilles, Sandrine Betuing   +2 more
exaly   +2 more sources

CYP46A1, the rate-limiting enzyme for cholesterol degradation, is neuroprotective in Huntington's disease. [PDF]

Brain, 2016
International audienceHuntington’s disease is an autosomal dominant neurodegenerative disease caused by abnormal polyglutamine expansion in huntingtin (Exp-HTT) leading to degeneration of striatal neurons.
Sandro Alves, Sandrine Betuing, Nicolas Heck   +2 more
exaly   +2 more sources

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The potential of CYP46A1 as a novel therapeutic target for neurological disorders: An updated review of mechanisms

European Journal of Pharmacology, 2023
Ali Roohbakhsh, Gholamreza Karimi, Mohaddeseh Sadat Alavi   +2 more
exaly  

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Frontiers in Aging Neuroscience, 2020
Hua-Dong Zhou, Yan-Jiang Wang, Fan Zeng
exaly  

Brain Acetyl-CoA Production and Phosphorylation of Cytoskeletal Proteins Are Targets of CYP46A1 Activity Modulation and Altered Sterol Flux

Neurotherapeutics, 2021
Natalia Mast, Irina Pikuleva, Alexey M. Petrov   +2 more
exaly  

Cholesterol 24-Hydroxylation by CYP46A1: Benefits of Modulation for Brain Diseases

Neurotherapeutics, 2019
Irina Pikuleva, Alexey M. Petrov
exaly  

Therapeutic implications of altered cholesterol homeostasis mediated by loss of CYP46A1 in human glioblastoma

EMBO Molecular Medicine, 2020
Mingzhi Han, Shuai Wang, Shuai Wang
exaly  

Neuronal differentiation alters the ratio of Sp transcription factors recruited to the CYP46A1 promoter.

Journal of Neurochemistry, 2012
Maria João Nunes, Maria João Gama, Margarida Castro-Caldas   +2 more
exaly