Results 1 to 10 of about 5,760 (129)

Circadian Clock Regulates Epidermal Endocrine System in Homeostatic Skin Pigmentation. [PDF]

Exp Dermatol
ABSTRACT The circadian clock regulates multiple physiological processes in the skin, including local hormone synthesis and pigmentation. However, how circadian regulation interacts with epidermal endocrine signalling in melanocytes remains unclear.
Zhu A, Yang L, Lai S, Yang F, Tsuruta D, Katayama I.   +5 more
europepmc   +2 more sources

Integrative multi-omics and machine learning reveals the spatial niche distribution and role of CYP27A1+TAMs in immunotherapy response in non-small cell lung cancer [PDF]

Frontiers in Immunology
BackgroundThe response rate to immune checkpoint blockade (ICB) in non-small cell lung cancer (NSCLC) varies significantly among individuals. Cancer-associated macrophages (TAMs) are key components of the tumor immune microenvironment (TIME), influencing
Qingsheng Liu, Xufeng Liu, Han Zhang, Yuhang Jiang, Ying Shi, Qiuqiao Mu, Yuhao Jing, Daqiang Sun   +7 more
doaj   +2 more sources

Tissue specific role of ABCA1 in lung cholesterol homeostasis under high-cholesterol diet [PDF]

Frontiers in Nutrition
BackgroundATP-binding cassette subfamily A1 (ABCA1) and sterol 27-hydroxylase (CYP27A1) are essential regulators of cholesterol metabolism. However, their tissue-specific roles, particularly in the lung, under high-cholesterol diet (HCD) conditions ...
Jian Ma, Jian Ma, Zhongwen Gong, Hong Lu, Han Yang, Shengquan Wang, Qian Zhu, Hongya Liu, Yongjia Li, Yuemei Zhang, Xuemei Lian, Xuemei Lian   +11 more
doaj   +2 more sources

CYP27A1 suppresses brain metastasis via ferroptosis in lung adenocarcinoma: a six-gene signature predicting the immunotherapy response and clinical outcomes [PDF]

Cancer Cell International
Background: Lung adenocarcinoma (LUAD) brain metastasis has limited therapeutic options and a poor prognosis. This study aimed to identify molecular drivers, construct a prognostic model, and assess immunotherapy response.
Lu Xu, Liyou Huang, Zihao Liu, Xiaojie Jiang, Linchun Wen   +4 more
doaj   +2 more sources

Polygenic Prediction of Equestrian Sport Discipline Among Horses Bred for Jumping and Dressage. [PDF]

Anim Genet
ABSTRACT Horses bred for different equestrian sports vary in physical, physiological and behavioural requirements. Characterising genetic markers associated with discipline provides an opportunity to improve identification of horses best suited to either jumping or dressage.
Hill EW, Han H, Holtby AR, Anhold H, McGivney BA.   +4 more
europepmc   +2 more sources

CYP27A1-27-hydroxycholesterol axis in the respiratory system contributes to house dust mite-induced allergic airway inflammation

Allergology International
Background: 27-Hydroxycholesterol (27-HC) derived from sterol 27-hydroxylase (CYP27A1) has pro-inflammatory biological activity and is associated with oxidative stress and chronic inflammation in COPD.
Yorihiko Kyogoku
exaly   +3 more sources

Heterozygous CYP27A1 gene mutation presenting with Achilles tendon xanthoma: a case report [PDF]

Journal of Medical Case Reports
Background Cerebrotendinous xanthomatosis is a rare autosomal recessive lipid storage disorder involving bile acid biosynthesis. Reduced mitochondrial cytochrome P450 enzyme activity leads to abnormal lipid accumulation in various tissues, especially ...
Yushi Oyama, Keishiro Okawa, Takuya Miyagi, Takahiro Sakai, Kyuhachi Otagiri, Hiroshi Kitabayashi   +5 more
doaj   +2 more sources

Targeting Brain Cholesterol Homeostasis in Alzheimer's Disease: Mechanisms and Therapeutic Perspectives. [PDF]

J Neurochem
Brain cholesterol homeostasis is tightly regulated and largely independent of peripheral cholesterol. This review proposes a unifying framework in which aging, sex, and related biological stressors, including hypercholesterolemia, neurodegeneration, inflammation, and oxidative stress, converge to disrupt cholesterol homeostasis in the brain ...
Ruthirakuhan M, Taha AY, Swardfager W.
europepmc   +2 more sources

NPC1L1 Drives Osteoporosis by Activating the C/EBPα/Cyp27a1/27‐Hydroxycholesterol Axis: A Novel Therapeutic Target for Bone Loss [PDF]

FASEB BioAdvances
This study investigated how NPC1L1, a cholesterol transporter, regulates osteogenic differentiation through cholesterol metabolism independently of its transport function.
Bohao Li, Wuling Zhou, Yueming Yu, Boyu Chen, Zhicheng Lv, Jiarui Zhang, Tieqi Zhang, Shiwei Sun, Lei Zhou, Minghai Wang   +9 more
doaj   +2 more sources

Genetic variants in the vitamin D pathway genes are predictors of the risk of diabetic kidney disease in Central Asian Kazakhstani cohort with type 2 diabetes [PDF]

Frontiers in Medicine
IntroductionDiabetic kidney disease (DKD) is a common microvascular complication of type 2 diabetes mellitus (T2DM). Given vitamin D’s roles in glucose metabolism and renal function, this study investigated associations between common variants in vitamin
Binura Taurbekova, Abay Tursunov, Aida Kabibulatova, Alimzhan Muxunov, Assel Issabayeva, Kuralay Atageldiyeva, Kuralay Atageldiyeva, Kamilya Sydykova, Aigul Durmanova, Akbayan Markabayeva, Andrey Starodubov, Kymbat Mukhtarova, Wassim Y. Almawi, Antonio Sarria-Santamera   +13 more
doaj   +2 more sources