CYP27A1 deficiency promoted osteoclast differentiation [PDF]
PeerJ, 2023 Background The elevating osteoclast differentiation can lead to an imbalance in bone homeostasis, which was responsible for bone loss and bone diseases, such as osteoporosis. Multiple pathways and molecules have been involved in osteoclast formation, but
Ziqi Fang +3 more
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PXR induces CYP27A1 and regulates cholesterol metabolism in the intestine [PDF]
Journal of Lipid Research, 2007 Mitochondrial sterol 27-hydroxylase (CYP27A1) catalyzes oxidative cleavage of the sterol side chain in the bile acid biosynthetic pathway in the liver and 27-hydroxylation of cholesterol in most tissues. Recent studies suggest that 27-hydroxycholesterol (
Tiangang Li +2 more
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On the substrate specificity of human CYP27A1 [PDF]
Journal of Lipid Research, 2003 The mitochondrial sterol 27-hydroxylase (CYP27A1) is required for degradation of the C27-sterol side chain in bile acid biosynthesis. CYP27A1 seems, however, to have roles beyond this, as illustrated by patients with a deficient sterol 27-hydroxylase due
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Cell Death and Disease, 2023 Cholesterol metabolism plays a critical role in the progression of hepatocellular carcinoma (HCC), but it is not clear how cholesterol metabolism is regulated.
Xiaobo Wang +8 more
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NPC1L1 Drives Osteoporosis by Activating the C/EBPα/Cyp27a1/27‐Hydroxycholesterol Axis: A Novel Therapeutic Target for Bone Loss [PDF]
FASEB BioAdvancesThis study investigated how NPC1L1, a cholesterol transporter, regulates osteogenic differentiation through cholesterol metabolism independently of its transport function.
Bohao Li +9 more
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Increased maternal and fetal cholesterol efflux capacity and placental CYP27A1 expression in preeclampsia[S] [PDF]
Journal of Lipid Research, 2017 Preeclampsia is a pregnancy-specific condition that leads to increased cardiovascular risk in later life. A decrease in cholesterol efflux capacity is linked to CVD.
Hiten D. Mistry +5 more
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Molecular dynamics, docking and quantum calculations reveal conformational changes influenced by CYP271A amino acid mutations related to cerebrotendinous xanthomatosis [PDF]
Scientific ReportsCerebrotendinous xanthomatosis (CTX) is an autosomal recessive lipid disorder caused by a deficiency in CYP27A1, the first enzyme in the bile acid biosynthesis pathway.
Yudibeth Sixto-López +4 more
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Cholesterol‐27α‐hydroxylase inhibitor nilvadipine can effectively treat cholestatic liver injury in adult offspring induced by prenatal dexamethasone exposure [PDF]
MedCommPrenatal dexamethasone exposure (PDE) can increase offspring susceptibility to various diseases. However, the pathogenesis and early prevention for PDE offspring prone to cholestatic liver injury have been unclear.
Wen Hu +7 more
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Clinical and genetic analysis of a family with cerebrotendinous xanthomatosis [PDF]
Frontiers in NeurologyObjectiveThis study aims to analyze the clinical and genetic characteristics of cerebrotendinous xanthomatosis (CTX) in a Chinese family.MethodsClinical data, including medical history, neurologic and auxiliary examinations, imaging studies, and genetic ...
You Guoliang +10 more
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Poultry Science, 2023 : Vitamin D3 is hydroxylated by cytochrome P450 (CYP) before exerting biological effects. The chicken CYP involved in vitamin D3 25-hydroxylation has yet to be cloned, and little is known about its functional characteristics, tissue distribution, and ...
S. Shang +8 more
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