Results 11 to 20 of about 6,856 (158)
Breast Cancer Research, 2020 Background 27-Hydroxycholesterol (27HC) stimulates estrogen receptor-positive (ER+) breast cancer (BC) progression. Inhibiting the sterol 27-hydroxylase (CYP27A1) abrogates these growth-promoting effects of 27HC in mice.
Siker Kimbung +10 more
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27-Hydroxylation of oncosterone by CYP27A1 switches its activity from pro-tumor to anti-tumor
Journal of Lipid Research, 2023 Oncosterone (6-oxo-cholestane-3β,5α-diol; OCDO) is an oncometabolite and a tumor promoter on estrogen receptor alpha-positive breast cancer (ER(+) BC) and triple-negative breast cancers (TN BC). OCDO is an oxysterol formed in three steps from cholesterol:
Silia Ayadi +7 more
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Increased maternal and fetal cholesterol efflux capacity and placental CYP27A1 expression in preeclampsia[S] [PDF]
Journal of Lipid Research, 2017 Preeclampsia is a pregnancy-specific condition that leads to increased cardiovascular risk in later life. A decrease in cholesterol efflux capacity is linked to CVD.
Hiten D. Mistry +5 more
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Hormonal Regulation of the Human CYP27A1 and CYP7B1 Genes [Elektronisk resurs]
, 2007 CYP27A1 and CYP7B1 are widely expressed in various human tissues and are two key enzymes involved in the pathways for conversion of cholesterol to bile acids.
Norlin, Maria +3 more
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BMC Immunology, 2023 Background The association between lipid metabolism disorder and carcinogenesis is well-established, but there is limited research on the connection between lipid metabolism-related genes (LRGs) and lung adenocarcinoma (LUAD).
Yi Yin +3 more
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Hepatic caveolin-1 is enhanced in Cyp27a1/ApoE double knockout mice [PDF]
, 2016 Sterol 27-hydroxylase (CYP27A1) is involved in bile acid synthesis and cholesterol homoeostasis. Cyp27a1(-/-)/Apolipoprotein E(-/-) double knockout mice (DKO) fed a western diet failed to develop atherosclerosis. Caveolin-1 (CAV-1), the main component of
Mansour, Yosef T. +16 more
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Activity of 25-hydroxylase in human gingival fibroblasts and periodontal ligament cells. [PDF]
PLoS ONE, 2012 We previously demonstrated that 25-hydroxyvitamin D(3) concentrations in gingival crevicular fluid are 300 times higher than those in the plasma of patients with aggressive periodontitis. Here we explored whether 25-hydroxyvitamin D(3) can be synthesized
Kaining Liu, Huanxin Meng, Jianxia Hou
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Molecular Therapy: Methods & Clinical Development, 2021 Cerebrotendinous xanthomatosis (CTX) is an autosomal recessive disease caused by mutations in the CYP27A1 gene, encoding the sterol 27-hydroxylase. Disruption of the bile acid biosynthesis pathway and accumulation of toxic precursors such as cholestanol ...
Sara Lumbreras +12 more
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PXR induces CYP27A1 and regulates cholesterol metabolism in the intestine
Journal of Lipid Research, 2007 Mitochondrial sterol 27-hydroxylase (CYP27A1) catalyzes oxidative cleavage of the sterol side chain in the bile acid biosynthetic pathway in the liver and 27-hydroxylation of cholesterol in most tissues. Recent studies suggest that 27-hydroxycholesterol (
Tiangang Li +2 more
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Zhongguo shiyan zhenduanxue, 2021 目的 研究CYP27A1对膀胱癌细胞的影响及其作用机制。方法 qRY-PCR检测膀胱癌细胞中AR和CYP27A1的mRNA水平;采用转染的实验技术使T24细胞稳定表达CYP27A1;MTT实验检测CYP27A1和27-HC对膀胱癌细胞增殖的影响;裸鼠移植瘤模型检测CYP27A1对膀胱癌细胞增殖的影响;ELIAE检测细胞上清液中27-HC的含量。结果 T24细胞中AR处于高表达水平CYP27A1处于低表达水平,5637细胞中AR处于低表达水平,CYP27A1处于高表达水平 ...
景中民, 朱海松, 徐海亮, 张超
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