Results 11 to 20 of about 5,760 (129)
CYP27A1 deficiency promoted osteoclast differentiation [PDF]
PeerJ, 2023 Background The elevating osteoclast differentiation can lead to an imbalance in bone homeostasis, which was responsible for bone loss and bone diseases, such as osteoporosis. Multiple pathways and molecules have been involved in osteoclast formation, but
Ziqi Fang +3 more
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Poultry Science, 2023 : Vitamin D3 is hydroxylated by cytochrome P450 (CYP) before exerting biological effects. The chicken CYP involved in vitamin D3 25-hydroxylation has yet to be cloned, and little is known about its functional characteristics, tissue distribution, and ...
S. Shang +8 more
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BMC Immunology, 2023 Background The association between lipid metabolism disorder and carcinogenesis is well-established, but there is limited research on the connection between lipid metabolism-related genes (LRGs) and lung adenocarcinoma (LUAD).
Yi Yin +3 more
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Breast Cancer Research, 2020 Background 27-Hydroxycholesterol (27HC) stimulates estrogen receptor-positive (ER+) breast cancer (BC) progression. Inhibiting the sterol 27-hydroxylase (CYP27A1) abrogates these growth-promoting effects of 27HC in mice.
Siker Kimbung +10 more
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Activity of 25-hydroxylase in human gingival fibroblasts and periodontal ligament cells. [PDF]
PLoS ONE, 2012 We previously demonstrated that 25-hydroxyvitamin D(3) concentrations in gingival crevicular fluid are 300 times higher than those in the plasma of patients with aggressive periodontitis. Here we explored whether 25-hydroxyvitamin D(3) can be synthesized
Kaining Liu, Huanxin Meng, Jianxia Hou
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27-Hydroxylation of oncosterone by CYP27A1 switches its activity from pro-tumor to anti-tumor
Journal of Lipid Research, 2023 Oncosterone (6-oxo-cholestane-3β,5α-diol; OCDO) is an oncometabolite and a tumor promoter on estrogen receptor alpha-positive breast cancer (ER(+) BC) and triple-negative breast cancers (TN BC). OCDO is an oxysterol formed in three steps from cholesterol:
Silia Ayadi +7 more
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Molecular Therapy: Methods & Clinical Development, 2021 Cerebrotendinous xanthomatosis (CTX) is an autosomal recessive disease caused by mutations in the CYP27A1 gene, encoding the sterol 27-hydroxylase. Disruption of the bile acid biosynthesis pathway and accumulation of toxic precursors such as cholestanol ...
Sara Lumbreras +12 more
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PXR induces CYP27A1 and regulates cholesterol metabolism in the intestine
Journal of Lipid Research, 2007 Mitochondrial sterol 27-hydroxylase (CYP27A1) catalyzes oxidative cleavage of the sterol side chain in the bile acid biosynthetic pathway in the liver and 27-hydroxylation of cholesterol in most tissues. Recent studies suggest that 27-hydroxycholesterol (
Tiangang Li +2 more
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Zhongguo shiyan zhenduanxue, 2021 目的 研究CYP27A1对膀胱癌细胞的影响及其作用机制。方法 qRY-PCR检测膀胱癌细胞中AR和CYP27A1的mRNA水平;采用转染的实验技术使T24细胞稳定表达CYP27A1;MTT实验检测CYP27A1和27-HC对膀胱癌细胞增殖的影响;裸鼠移植瘤模型检测CYP27A1对膀胱癌细胞增殖的影响;ELIAE检测细胞上清液中27-HC的含量。结果 T24细胞中AR处于高表达水平CYP27A1处于低表达水平,5637细胞中AR处于低表达水平,CYP27A1处于高表达水平 ...
景中民, 朱海松, 徐海亮, 张超
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Enzyme activity assay for cholesterol 27-hydroxylase in mitochondria
Journal of Lipid Research, 2006 Mitochondrial cholesterol 27-hydroxylase (CYP27A1) plays an important role in the maintenance of intracellular cholesterol homeostasis. Cholesterol delivery to the mitochondrial inner membrane is believed to be a rate-limiting step for the “acidic ...
Xiaobo Li +3 more
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