Results 21 to 30 of about 9,315 (207)

Metabolism of Lumisterol2 by CYP27A1

The Journal of Steroid Biochemistry and Molecular Biology, 2023
Lumisterol2 (L2) is a photoproduct of UVB action on the fungal membrane sterol, ergosterol. Like vitamin D2, it is present in edible mushrooms, especially after UV irradiation. Lumisterol3 is similarly produced in human skin from 7-dehydrocholesterol by UVB and can be converted to hydroxy-metabolites by CYP27A1 and CYP11A1.
Dongxian, Wu, Gareth, Nealon, Yuchen, Liu, Tae-Kang, Kim, Andrzej T, Slominski, Robert C, Tuckey   +5 more
openaire   +2 more sources

Transcriptomic analysis identifies CYP27A1 as a diagnostic marker for the prognosis and immunity in lung adenocarcinoma

BMC Immunology, 2023
Background The association between lipid metabolism disorder and carcinogenesis is well-established, but there is limited research on the connection between lipid metabolism-related genes (LRGs) and lung adenocarcinoma (LUAD).
Yi Yin, Muqun He, Yunjian Huang, Xianhe Xie   +3 more
doaj   +1 more source

Optimization of CYP27A1 recombinant protein expression. [PDF]

Protein Expr Purif
Papa JE, Vaughn LR, Bartholomew-Schoch JL, Stone EK, Culpepper MA, Reddish MJ.   +5 more
europepmc   +3 more sources

Activity of 25-hydroxylase in human gingival fibroblasts and periodontal ligament cells. [PDF]

PLoS ONE, 2012
We previously demonstrated that 25-hydroxyvitamin D(3) concentrations in gingival crevicular fluid are 300 times higher than those in the plasma of patients with aggressive periodontitis. Here we explored whether 25-hydroxyvitamin D(3) can be synthesized
Kaining Liu, Huanxin Meng, Jianxia Hou
doaj   +1 more source

Host CYP27A1 expression is essential for ovarian cancer progression [PDF]

Endocrine-Related Cancer, 2019
There is an urgent need for more effective strategies to treat ovarian cancer. Elevated cholesterol levels are associated with a decreased progression-free survival time (PFS) while statins are protective. 27-Hydroxycholesterol (27HC), a primary metabolite of cholesterol, has been shown to modulate the activities of the estrogen receptors (ERs) and ...
Sisi, He, Liqian, Ma, Amy E, Baek, Anna, Vardanyan, Varsha, Vembar, Joy J, Chen, Adam T, Nelson, Joanna E, Burdette, Erik R, Nelson   +8 more
openaire   +2 more sources

Cerebrotendinous xanthomatosis: recurrence of the CYP27A1 mutation p.Arg479Cys in Sardinia [PDF]

Neurological Sciences, 2014
Cerebrotendinous xanthomatosis (CTX) is a rare autosomal recessive disorder, due to mutations of the CYP27A1 gene, leading to cholestanol accumulation because of the sterol27-hydroxylase enzyme deficiency [1]. Treatment with chenodeoxycholic acid (CDCA) normalizes cholestanol and improves neurophysiological findings.
Mandrile G, GALLUS, GIAN NICOLA, Mura G, Di Sapio A, Sotgiu MA, Montella A, Giachino DF, DOTTI, MARIA, Ulgheri L, FEDERICO, ANTONIO   +9 more
openaire   +5 more sources

Vitamin D enzymes (CYP27A1, CYP27B1 and CYP24A1) and receptor expression in non-melanoma skin cancer [PDF]

, 2019
No abstract available for this ...
Apostolopoulos, Vasso, Blatch, Gregory L, Dass, Crispin R, Nemazannikova, Natalie, Sinclair, Rodney   +4 more
core   +2 more sources

27-Hydroxylation of oncosterone by CYP27A1 switches its activity from pro-tumor to anti-tumor

Journal of Lipid Research, 2023
Oncosterone (6-oxo-cholestane-3β,5α-diol; OCDO) is an oncometabolite and a tumor promoter on estrogen receptor alpha-positive breast cancer (ER(+) BC) and triple-negative breast cancers (TN BC). OCDO is an oxysterol formed in three steps from cholesterol:
Silia Ayadi, Silvia Friedrichs, Regis Soulès, Laly Pucheu, Dieter Lütjohann, Sandrine Silvente-Poirot, Marc Poirot, Philippe de Medina   +7 more
doaj   +1 more source

Cholestenoic acid, an endogenous cholesterol metabolite, is a potent γ-secretase modulator. [PDF]

, 2015
BackgroundAmyloid-β (Aβ) 42 has been implicated as the initiating molecule in the pathogenesis of Alzheimer's disease (AD); thus, therapeutic strategies that target Aβ42 are of great interest.
Akula, Rajender, Ba, Saritha, Ceballos-Diaz, Carolina, Felsenstein, Kevin M, Golde, Todd E, Hochhaus, Günther, Jung, Joo In, Koo, Edward H, Ladd, Thomas B, Park, Hyo-Jin, Price, Ashleigh R, Ran, Yong, Shapiro, Gideon, Smithson, Lisa A, Tang, Yufei   +14 more
core   +3 more sources

Gene supplementation of CYP27A1 in the liver restores bile acid metabolism in a mouse model of cerebrotendinous xanthomatosis

Molecular Therapy: Methods & Clinical Development, 2021
Cerebrotendinous xanthomatosis (CTX) is an autosomal recessive disease caused by mutations in the CYP27A1 gene, encoding the sterol 27-hydroxylase. Disruption of the bile acid biosynthesis pathway and accumulation of toxic precursors such as cholestanol ...
Sara Lumbreras, Ana Ricobaraza, Lucia Baila-Rueda, Manuela Gonzalez-Aparicio, Lucia Mora-Jimenez, Iker Uriarte, Maria Bunuales, Matias A. Avila, Maria J. Monte, Jose J.G. Marin, Ana Cenarro, Gloria Gonzalez-Aseguinolaza, Ruben Hernandez-Alcoceba   +12 more
doaj   +1 more source