Results 21 to 30 of about 6,856 (158)
Enzyme activity assay for cholesterol 27-hydroxylase in mitochondria
Journal of Lipid Research, 2006 Mitochondrial cholesterol 27-hydroxylase (CYP27A1) plays an important role in the maintenance of intracellular cholesterol homeostasis. Cholesterol delivery to the mitochondrial inner membrane is believed to be a rate-limiting step for the “acidic ...
Xiaobo Li +3 more
doaj +1 more source
A novel CYP27A1 frameshift mutation causing cerebrotendinous xanthomatosis in an Indian family
Annals of Movement Disorders, 2022 Cerebrotendinous xanthomatosis is a rare and underreported lipid storage disorder caused by various mutations in the CYP27A1 gene. Here, we report a novel homozygous mutation in the CYP27A1 gene in an Indian family.
Shilpi Shukla +4 more
doaj +1 more source
Journal of Lipid Research, 2013 Posttranslational modification by isolevuglandins (isoLGs), arachidonate oxidation products, is an important yet understudied process associated with altered protein properties.
Casey D. Charvet +4 more
doaj +1 more source
International Journal of Endocrinology, 2015 Metabolic syndrome (MetS) confers increased risks of cardiovascular disease (CVD). Both vitamin D3 and adipocytokines (especially adiponectin and leptin) have a great impact on CVD and MetS.
Kai-Hung Cheng +10 more
doaj +1 more source
Journal of Lipid Research, 2010 The rare disease cerebrotendinous xanthomatosis (CTX) is due to a lack of sterol 27-hydroxylase (CYP27A1) and is characterized by cholestanol-containing xanthomas in brain and tendons. Mice with the same defect do not develop xanthomas. The driving force
Ann Båvner +7 more
doaj +1 more source
Hematopoietic overexpression of Cyp27a1 reduces hepatic inflammation independently of 27-hydroxycholesterol levels in Ldlr(-/-) mice [PDF]
, 2015 Background & Aims: Non-alcoholic steatohepatitis (NASH) is characterized by hepatic lipid accumulation and inflammation. Currently, the underlying mechanisms, leading to hepatic inflammation, are still unknown.
Luetjohann, D. +14 more
core +2 more sources
Dermatologica Sinica, 2018 Cerebrotendinous xanthomatosis (CTX), a rare autosomal recessive lipid storage disorder which is caused by mutations in gene CYP27A1 leads to deficiency of enzyme sterol 27-hydroxylase.
Jeng Yuan +3 more
doaj +1 more source
Cell Death and Disease, 2023 Cholesterol metabolism plays a critical role in the progression of hepatocellular carcinoma (HCC), but it is not clear how cholesterol metabolism is regulated.
Xiaobo Wang +8 more
doaj +1 more source
Role of CYP27A1 in progesterone metabolism in vitro and in vivo
, 2009 In the kidney, progesterone is inactivated to 20alpha-dihydro-progesterone (20alpha-DH-progesterone) to protect the mineralocorticoid receptor from progesterone excess.
Krozowski, Zygmunt +6 more
core +1 more source
On the substrate specificity of human CYP27A1
Journal of Lipid Research, 2003 The mitochondrial sterol 27-hydroxylase (CYP27A1) is required for degradation of the C27-sterol side chain in bile acid biosynthesis. CYP27A1 seems, however, to have roles beyond this, as illustrated by patients with a deficient sterol 27-hydroxylase due
Maria Norlin +3 more
doaj +1 more source