Results 91 to 100 of about 1,942 (152)

CYP46A1 activation by low-dose efavirenz uncovers the link between brain cholesterol metabolism, energetics, and vasculature. [PDF]

Biomed Pharmacother
Mast N, Bederman I, El-Darzi N, Pikuleva IA.   +3 more
europepmc   +1 more source

CYP46A1 Activation Improves Retinal Neovascularization in a Mouse Model of Retinopathy of Prematurity.

Previous studies have shown the metabolic and regulatory significance of CYP46A1 in the adult retina; however, its role in the developing retina is unknown.
Thounaojam, Menaka C, Bailey, Briah, Seth, Gayatri, Oxenrider, Allston, Zhong Manis, Josephine Rudd, Rajpurohit, Shubhra, Martin, Pamela M, Jadeja, Ravirajsinh N   +7 more
core  

Dysregulated Cholesterol Clearance via CYP46A1 Contributes to Cerebellar Sterol Imbalance in <i>Mecp2</i>-Null Mice. [PDF]

Int J Mol Sci
Tapia PJ, Rivera BI, Espinoza CS, Stolzenbach F, Yáñez MJ, Kerr B.   +5 more
europepmc   +1 more source

Cholesterol metabolism in neurodegenerative diseases: mechanisms and therapeutic advances. [PDF]

Mol Neurodegener
Tu D, Zheng Y, Ding P, Shen M, Tang W, Wei B, Wang H.   +6 more
europepmc   +1 more source

Restoring cholesterol homeostasis in neurons by cyp46a1 does not stall the progression of niemann-pick type C disease

Tese de mestrado, Ciências Biofarmacêuticas, 2022, Universidade de Lisboa, Faculdade de Farmácia.A enzima colesterol 24-hidroxilase (CYP46A1) consiste num citocromo P450 neuro-específico, que catalisa a conversão do colesterol em 24S-hydroxycholesterol ...
Reis, Joana Pinheiro Leite da Anunciação
core   +2 more sources

Radiosynthesis and Evaluation of ¹⁸F‑Labeled Deuterated Radioligand for Positron Emission Tomography Imaging of Cholesterol 24-Hydroxylase. [PDF]

ACS Med Chem Lett
Li Y, Song Z, Shi H, Zhao T, Chen J, Zhou X, Hu Q, Li X, Meng L, Song R, Sun Z, Li C, Haider A, Yuan H, Liang SH.   +14 more
europepmc   +1 more source

Cholesterol at the Center of Alzheimer's Disease: A Unifying Hypothesis on the Pathogenic Mechanism. [PDF]

Molecules
Zhu BT.
europepmc   +1 more source

Head-to-head comparison of [¹⁸F]CHL2205 versus [¹⁸F]T008 as PET radioligands to study brain cholesterol homeostasis in rodent models and nonhuman primates. [PDF]

Eur J Nucl Med Mol Imaging
Goutal S, Caille F, Piguet F, Goislard M, Amargier-Barrial S, Leterrier S, Marie S, Bottlaender M, Tournier N.   +8 more
europepmc   +1 more source

Clinical Failure Validates a Fifth Predictive Preclinical Antiseizure Medicine Discovery Model. [PDF]

Epilepsy Curr
Barker-Haliski M.
europepmc   +1 more source

Physiological Functions of Side-Chain-Retaining Sterols in the Brain and Their Roles in Neurodegenerative Diseases. [PDF]

Metabolites
Kiriyama Y, Nakatsuma A, Tokumaru H, Sadamoto H, Nochi H.   +4 more
europepmc   +1 more source