Results 91 to 100 of about 2,697 (198)

N,N-Dimethyl-3β-hydroxycholenamide Reduces Retinal Cholesterol via Partial Inhibition of Retinal Cholesterol Biosynthesis Rather Than its Liver X Receptor Transcriptional Activity

Frontiers in Pharmacology, 2018
N,N-dimethyl-3β-hydroxycholenamide (DMHCA) is an experimental pharmaceutical and a steroidal liver X receptor (LXR) agonist, which does not induce undesired hepatic lipogenesis.
Nicole El-Darzi, Artem Astafev, Natalia Mast, Aicha Saadane, Morrie Lam, Irina A. Pikuleva   +5 more
doaj   +1 more source

Role of platelet-derived growth factor B in cholesterol and glucose metabolism [PDF]

, 2017
Platelet-derived growth factor (PDGFB) is a critical molecule for recruiting pericytes. Due to the fundamental role of the pericytes in angiogenesis and vascular stability, PDGFB knockout mice die perinatally from severe hemorrhage and edema.
Li, Tian
core   +1 more source

Oxysterols and Their Cellular Effectors [PDF]

, 2012
Oxysterols are oxidized 27-carbon cholesterol derivatives or by-products of cholesterol biosynthesis, with a spectrum of biologic activities. Several oxysterols have cytotoxic and pro-apoptotic activities, the ability to interfere with the lateral domain
Béaslas, Olivier, Nissilä, Eija, Olkkonen, Vesa M.   +2 more
core   +3 more sources

Kinetics of the chromosome 14 microRNA cluster ortholog and its potential role during placental development in the pregnant mare [PDF]

, 2018
Background: The human chromosome 14 microRNA cluster (C14MC) is a conserved microRNA (miRNA) cluster across eutherian mammals, reported to play an important role in placental development.
Ball, Barry A, Carossino, Mariano, Daels, Peter, Dini, Pouya, Esteller-Vico, Alejandro, Loux, Shavahn C, Scoggin, Kirsten E   +6 more
core   +5 more sources

Okadaic acid inhibits the trichostatin A-mediated increase of human CYP46A1 neuronal expression in a ERK1/2-Sp3-dependent pathway

Journal of Lipid Research, 2012
The CYP46A1 gene codes for the cholesterol 24-hydroxylase, a cytochrome P450 specifically expressed in neurons and responsible for the majority of cholesterol turnover in the central nervous system.
Maria João Nunes, Miguel Moutinho, Inês Milagre, Maria João Gama, Elsa Rodrigues   +4 more
doaj   +1 more source

Impact of the Interaction between 3′-UTR SNPs and microRNA on the Expression of Human Xenobiotic Metabolism Enzyme and Transporter Genes [PDF]

, 2012
Genetic variation in the expression of human XMETs leads to inter-individual variability in metabolism of therapeutic agents as well as differed susceptibility to various diseases.
David A Flockhart, Fan eYang, Lang eLi, Naga eChalasani, Rongrong eWei, Thomas J. Urban, Wanqing eLiu, Wanqing eLiu   +7 more
core   +2 more sources

The Concise Guide to PHARMACOLOGY 2025/26: Enzymes

British Journal of Pharmacology, Volume 182, Issue S1, Page S307-S403, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander, Doriano Fabbro, Alasdair J. Gibb, Eamonn Kelly, Alistair A. Mathie, Chloe J. Peach, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Stephanie Annett, Detlev Boison, Kathryn Elisa Burns, Carmen Dessauer, Jürg Gertsch, Nuala Ann Helsby, Angelo A. Izzo, Rennolds Ostrom, Ester Pagano, Andreas Papapetropoulos, Nigel J. Pyne, Susan Pyne, Tracy Robson, Roland Seifert, Johannes‐Peter Stasch, Csaba Szabo, Mario van der Stelt, Albert van der Vliet, Val Watts, Szu Shen Wong   +31 more
wiley   +1 more source

Identifying Oxysterols Associated With Age and Diet in Mice Using Optimized Reversed‐phase Liquid Chromatography‐Mass Spectrometry (RPLC‐MS)

Journal of Separation Science, Volume 48, Issue 10, October 2025.
ABSTRACT Structurally similar oxysterols such as 7α‐hydroxycholesterol, 7β‐hydroxycholesterol, and 7‐ketocholesterol; 5,6α‐ and 5,6β‐epoxycholesterol; and 24(R/S)‐hydroxy cholesterol, 25‐hydroxy cholesterol, and 27‐hydroxycholesterol are traditionally difficult to resolve using reversed‐phase liquid chromatography (RPLC). We present a simple yet highly
Indhumathy Subramaniyan, Benjamin Barr, Ninh M. La‐Beck, Benjamin G. Janesko, Lauren Gollahon, Li Li   +5 more
wiley   +1 more source

Polymorphisms of CR1, CLU and PICALM confer susceptibility of Alzheimer's disease in a southern Chinese population [PDF]

, 2012
In this case-controlled study, we tested susceptible genetic variants for Alzheimer's disease (AD) in CR1, CLU and PICALM from genome-wide association studies (GWAS) in a southern Chinese population.
Chan, CSY, Chen, LH, Chu, LW, Fan, YH, Ha, JCT, Ho, DTY, Kao, PYP, Song, YQ, Yik, PY   +8 more
core   +1 more source

CYP46A1variants influence Alzheimer’s disease risk and brain cholesterol metabolism

European Psychiatry, 2009
AbstractBackgroundCholesterol 24S-hydroxylase (CYP46) catalyzes the conversion of cholesterol to 24S-hydroxycholesterol, the primary cerebral cholesterol elimination product. Only few gene variations in CYP46 gene (CYP46A1) have been investigated for their relevance as genetic risk factors of Alzheimer’s disease (AD) and results are contradictory ...
Heike, Kölsch, Dieter, Lütjohann, Frank, Jessen, Julius, Popp, Frank, Hentschel, Peter, Kelemen, Sandra, Schmitz, Wolfgang, Maier, Reinhard, Heun   +8 more
openaire   +2 more sources