Results 61 to 70 of about 1,473 (145)

Cholesterol and oxysterols in retinal neuron-glia interactions: relevance for glaucoma

Frontiers in Ophthalmology
Cholesterol is an essential component of cellular membranes, crucial for maintaining their structural and functional integrity. It is especially important for nervous tissues, including the retina, which rely on high amounts of plasma membranes for the ...
Elodie A.Y. Masson, Jeanne Serrano, Jeanne Serrano, Elise Leger-Charnay, Niyazi Acar   +4 more
doaj   +1 more source

Construction and verification of an endoplasmic reticulum stress-related prognostic model for endometrial cancer based on WGCNA and machine learning algorithms

Frontiers in Oncology
BackgroundEndoplasmic reticulum (ER) stress arises from the accumulation of misfolded or unfolded proteins within the cell and is intricately linked to the initiation and progression of various tumors and their therapeutic strategies.
Shanshan Lin, Changqiang Wei, Yiyun Wei, Jiangtao Fan   +3 more
doaj   +1 more source

CYP46A1 Activation Improves Retinal Neovascularization in a Mouse Model of Retinopathy of Prematurity

Abstract Previous studies have shown the metabolic and regulatory significance of CYP46A1 in the adult retina; however, its role in the developing retina is unknown. Here, we evaluate CYP46A1 expression and the impact of its activation in the developing mouse retina under normal and pathological conditions.
Bailey, Briah, Zhong Manis, Josephine Rudd, Seth, Gayatri, Rajpurohit, Shubhra, Oxenrider, Allston, Martin, Pamela M., Jadeja, Ravirajsinh N., Thounaojam, Menaka C.   +7 more
openaire   +2 more sources

Salinity modulates gut microbiota and host transcriptome dynamics in juvenile euryhaline fish yellowfin seabream (Acanthopagrus latus)

Aquaculture Reports
Salinity critically modulates physiological adaptations in aquatic animals, particularly in euryhaline species frequently encountering salinity fluctuations. Here, we investigated how environmental salinity (10 ppt vs.
Cheng Peng, Huayi Xue, Jingjing Zhang, Jin Zhang, Jiage Dai, Yong Zhang, Shijia Hu   +6 more
doaj   +1 more source

Quantitative Determination of Cholesterol Hydroxylase Specificities by GC–MS/MS in Living Mammalian Cells

Bio-Protocol
Cholesterol is oxygenated by a variety of cholesterol hydroxylases; oxysterols play diverse important roles in physiological and pathophysiological conditions by regulating several transcription factors and cell-surface receptors.
Hodaka Saito, Mizuki Nishimura, Ryuichiro Sato, Yoshio Yamauchi   +3 more
doaj   +1 more source

Editorial: Cholesterol and Neurodegenerative Diseases - Pressing Questions and How to Address Them

Frontiers in Aging Neuroscience, 2022
Sandrine Betuing, Sandrine Betuing, Sandrine Betuing, Irina A. Pikuleva, Joseph M. Castellano   +4 more
doaj   +1 more source

CYP46A1-Targeted Treatment Alleviates Long-Term White Matter Injury Following Traumatic Brain Injury by Promoting Cholesterol Metabolic Clearance and Remyelination. [PDF]

CNS Neurosci Ther
Li L, Shi Y, Luo Q, Guo P, Jin T, Ru X, Jiang Z, Niu Y, Li W, Chen Y, Chen Z.   +10 more
europepmc   +1 more source

CYP46A1 activation by low-dose efavirenz uncovers the link between brain cholesterol metabolism, energetics, and vasculature. [PDF]

Biomed Pharmacother
Mast N, Bederman I, El-Darzi N, Pikuleva IA.   +3 more
europepmc   +1 more source

Targeting Brain Cholesterol Homeostasis in Alzheimer's Disease: Mechanisms and Therapeutic Perspectives. [PDF]

J Neurochem
Ruthirakuhan M, Taha AY, Swardfager W.
europepmc   +1 more source

Radiosynthesis and Evaluation of ¹⁸F‑Labeled Deuterated Radioligand for Positron Emission Tomography Imaging of Cholesterol 24-Hydroxylase. [PDF]

ACS Med Chem Lett
Li Y, Song Z, Shi H, Zhao T, Chen J, Zhou X, Hu Q, Li X, Meng L, Song R, Sun Z, Li C, Haider A, Yuan H, Liang SH.   +14 more
europepmc   +1 more source