Results 61 to 70 of about 2,697 (198)

Altered Cholesterol Homeostasis in Huntington’s Disease

Frontiers in Aging Neuroscience, 2022
Huntington’s disease (HD) is an autosomal dominant genetic disorder caused by an expansion of the CAG repeat in the first exon of Huntingtin’s gene.
Radhia Kacher, Radhia Kacher, Coline Mounier, Coline Mounier, Coline Mounier, Jocelyne Caboche, Jocelyne Caboche, Jocelyne Caboche, Sandrine Betuing, Sandrine Betuing, Sandrine Betuing   +10 more
doaj   +1 more source

Cholesterolomics: An update [PDF]

, 2017
Cholesterolomics can be regarded as the identification and quantification of cholesterol, its precursors post squalene, and metabolites of cholesterol and of its precursors, in a biological sample.
Alvelius, Alwena H. Morgan, Andersson, Axelson, Bauman, Bazan, Bjorkhem, Bjorkhem, Bjorkhem, Blanc, Byrne, Cobice, Crick, Crick, Davies, de Medina, Diczfalusy, Dzeletovic, Eylan Yutuc, Fakheri, Griffiths, Griffiths, Griffiths, Griffiths, Griffiths, Griffiths, Gustafsson, Hannedouche, Hu, Ian Gilmore, Ikegami, Jiang, Jiang, Jonas Abdel-Khalik, Klinke, Korade, Kotti, Lehmann, Lin, Liu, Liu, Liu, Maioli, Matysik, Mazzacuva, McDonald, McDonald, McDonald, Myers, Nachtergaele, Nedelcu, Nelson, Novakova, Park, Pataj, Porter, Porter, Radhakrishnan, Reboldi, Roberg-Larsen, Roberg-Larsen, Robertson, Russell, Sacchetti, Saeed, Saeed, Santori, Schroepfer, Setchell, Sever, Shinkyo, Sidhu, Silvente-Poirot, Simigdala, Soncini, Soroosh, Stiles, Theofilopoulos, Theofilopoulos, Thomas Hearn, Wassif, Watabe, William J. Griffiths, Wu, Xu, Yuqin Wang, Zhang   +86 more
core   +1 more source

Inhibition of SLC11A1‐Mediated Lysosomal Iron Accumulation in Microglia Promotes Repair Following White Matter Stroke

Advanced Science, Volume 13, Issue 19, 2 April 2026.
Genetic and pharmacological inhibition of SLC11A1 functioning as an H+/Fe2+ antiporter–mediated lysosomal iron accumulation in microglia promotes lysosomal lumen acidification, increases CTSD expression, enhances lysosomal myelin debris uptake and degradation, and promotes repair following white matter stroke. ABSTRACT White matter stroke (WMS) results
Lingling Qiu, Yajie Zhang, Yushi Tang, Hongli Hu, Ying Zhang, Junwen Xue, Hao Wang, Yecheng Wang, Chunfeng Liu, Jia Jia, Jian Cheng, Yongjun Cao   +11 more
wiley   +1 more source

PPAR-γ and CYP46A1 genes polymorphism is associated with Primary Open Angle Glaucoma (POAG) in hypertensive North Indians

Egyptian Journal of Medical Human Genetics, 2017
Background: Involvement of genetic factors like gene polymorphisms was found to contribute significantly to development and progression of Primary Open Angle Glaucoma (POAG) in the last few decades.
Syed Tasleem Raza, Saliha Rizvi, Luxmi Singh, Shania Abbas, Zeashan Haider Zaidi, Farzana Mahdi   +5 more
doaj   +1 more source

The CH24H metabolite, 24HC, blocks viral entry by disrupting intracellular cholesterol homeostasis

Redox Biology, 2023
Cholesterol-24-hydroxylase (CH24H or Cyp46a1) is a reticulum-associated membrane protein that plays an irreplaceable role in cholesterol metabolism in the brain and has been well-studied in several neuro-associated diseases in recent years.
Yueming Yuan, An Fang, Zongmei Wang, Zhihui Wang, Baokun Sui, Yunkai Zhu, Yuan Zhang, Caiqian Wang, Rong Zhang, Ming Zhou, Huanchun Chen, Zhen F. Fu, Ling Zhao   +12 more
doaj   +1 more source

Neuroendocrine Regulation of Metabolism [PDF]

, 2016
Given the current environment in most developed countries, it is a challenge to maintain a good balance between calories consumed and calories burned, although maintenance of metabolic balance is key to good health. Therefore, understanding how metabolic
Becu Villalobos, D., Coirini, Hector, Cornejo, María Paula, Elias, C. F., Hentges, S.T., Maliqueo, M.   +5 more
core   +3 more sources

Excitotoxicity increases the release of 24S-hydroxycholesterol via CYP46A1 activation [PDF]

Molecular Neurodegeneration, 2013
Background Excitotoxicity, a common hallmark of different neurological disorders including Alzheimer’s disease (AD), is the consequence of exacerbated neuronal stimulation and leads to a high influx of calcium trough membrane glutamate receptors [1]. On the other hand, high levels of the cholesterol metabolite 24S-hydroxycholesterol (24-HC) have been ...
Sodero, Alejandro, Vriens, Joris, Ghosh, Debapriya, Stegner, David, Brachet, Anna, Pallotto, Marta, Sassoe-Pognetto, Marco, Brouwers, Jos, Helms, Bernd, Nieswandt, Bernard, Voets, Thomas, Dotti, Carlos   +11 more
openaire   +1 more source

A CYPome-wide study reveals new potential players in the pathogenesis of Parkinson’s disease

Frontiers in Pharmacology, 2023
Genetic and environmental factors lead to the manifestation of Parkinson’s disease (PD) but related mechanisms are only rudimentarily understood. Cytochromes P450 (P450s) are involved in the biotransformation of toxic compounds and in many physiological ...
Philip Hartz, Tobias Fehlmann, Gudrun Wagenpfeil, Marcus Michael Unger, Marcus Michael Unger, Rita Bernhardt   +5 more
doaj   +1 more source

Charge-tagging liquid chromatography–mass spectrometry methodology targeting oxysterol diastereoisomers [PDF]

, 2017
The introduction of a hydroxy group to the cholesterol skeleton introduces not only the possibility for positional isomers but also diastereoisomers, where two or more isomers have different configurations at one or more of the stereocentres but are not ...
Abdel-Khalik, Alison Dickson, Alvelius, Crick, Crick, DeBarber, Dzeletovic, Eylan Yutuc, Furster, Griffiths, Griffiths, Griffiths, Hult, Jonas Abdel-Khalik, Larsson, Lütjohann, McDonald, Meljon, Mitic, Murphy, Natowicz, Peter J. Crick, Quehenberger, Russell, Schroepfer, Shinkyo, Theofilopoulos, Thomas Hearn, Vilarinho, William J. Griffiths, Yuqin Wang   +30 more
core   +2 more sources

CYP46A1 gene therapy deciphers the role of brain cholesterol metabolism in Huntington’s disease [PDF]

Brain, 2019
AbstractDysfunctions in brain cholesterol homeostasis have been extensively related to brain disorders. The main pathway for brain cholesterol elimination is its hydroxylation into 24S-hydroxycholesterol by the cholesterol 24-hydrolase, CYP46A1.
Kacher, Radhia, Lamazière, Antonin, Heck, Nicolas, Kappes, Vincent, Mounier, Coline, Despres, Gaëtan, Dembitskaya, Yulia, Perrin, Elodie, Christaller, Wilhelm, Sasidharan Nair, Satish, Messent, Valérie, Cartier, Nathalie, Vanhoutte, Peter, Venance, Laurent, Saudou, Frédéric, Néri, Christian, Caboche, Jocelyne, Betuing, Sandrine   +17 more
openaire   +3 more sources