Results 61 to 70 of about 1,942 (152)

Deletion of TSPO Causes Dysregulation of Cholesterol Metabolism in Mouse Retina

Cells, 2021
Cholesterol dysregulation has been implicated in age-related macular degeneration (AMD), the most common cause of visual impairment in the elderly.
Fahad Farhan, Mohammad Almarhoun, Aileen Wong, Amy S. Findlay, Chris Bartholomew, Mark T. S. Williams, Toby W. Hurd, Xinhua Shu   +7 more
doaj   +1 more source

Changes in the gut microbiome during fasting‐induced molting and its effects on gut–liver function

iMetaOmics, Volume 3, Issue 2, June 2026.
During fasting, harmful microbiota and metabolites rise, triggering intestinal injury and activation of the TGF‐β signaling pathway, which enhances intestinal stem cell proliferation. Concurrently, hepatic function declines, indicated by increased hepatic and serum bile acids and upregulation of the non‐classical bile acid synthesis pathway.
Hao Zhang, Zhixuan Luo, Jun Zhang, Chenxu Wang, Yadong Tian, Donghua Li, Yujie Guo, Yanhua Zhang, Wenting Li, Yujie Gong, Xiangtao Kang, Ruirui Jiang   +11 more
wiley   +1 more source

Okadaic acid inhibits the trichostatin A-mediated increase of human CYP46A1 neuronal expression in a ERK1/2-Sp3-dependent pathway

Journal of Lipid Research, 2012
The CYP46A1 gene codes for the cholesterol 24-hydroxylase, a cytochrome P450 specifically expressed in neurons and responsible for the majority of cholesterol turnover in the central nervous system.
Maria João Nunes, Miguel Moutinho, Inês Milagre, Maria João Gama, Elsa Rodrigues   +4 more
doaj   +1 more source

Inhibition of SLC11A1‐Mediated Lysosomal Iron Accumulation in Microglia Promotes Repair Following White Matter Stroke

Advanced Science, Volume 13, Issue 19, 2 April 2026.
Genetic and pharmacological inhibition of SLC11A1 functioning as an H+/Fe2+ antiporter–mediated lysosomal iron accumulation in microglia promotes lysosomal lumen acidification, increases CTSD expression, enhances lysosomal myelin debris uptake and degradation, and promotes repair following white matter stroke. ABSTRACT White matter stroke (WMS) results
Lingling Qiu, Yajie Zhang, Yushi Tang, Hongli Hu, Ying Zhang, Junwen Xue, Hao Wang, Yecheng Wang, Chunfeng Liu, Jia Jia, Jian Cheng, Yongjun Cao   +11 more
wiley   +1 more source

Histological Study on the Therapeutic Effect of Gene Modified Bone Marrow Hemopoeitic Stem Cells (BMHSCs) Versus Unmodified BMHSCs Derived Exosomes in Early Diabetic Retinopathy Male Rat Model

The Egyptian Journal of Histology
Background and Objectives: Globally, one of the main causes of blindness and vision impairment in the working class is diabetic retinopathy (DR). The goal of the current study was to evaluate and investigate the therapeutic benefits of bone marrow ...
Maha Zickri, Zeinab Hegab, Hala Metwally, Nour Abdelwahab, Hossam El Din Kareem, Mohammed Hameed, layth AbdulAdeem, Taha Yousif, Mohamed AbdelRahman, Amal Farag   +9 more
doaj   +1 more source

Repeated Intake of Grapefruit Juice Inhibits CYP2B6, CYP2C9, CYP2C19, and CYP3A4 while Lingonberry Powder Does Not Induce Major CYP Enzymes in Humans

Clinical Pharmacology &Therapeutics, Volume 119, Issue 4, Page 953-963, April 2026.
Grapefruit juice is a well‐established inhibitor of cytochrome P450 (CYP) 3A4, but its effects on other CYP enzymes or organic anion transporting polypeptides (OATPs) are not fully characterized in humans. Recently, lingonberry powder was shown to induce murine CYP enzymes. We investigated the effects of lingonberry powder and grapefruit juice on seven
Laura Aurinsalo, Outi Lapatto‐Reiniluoto, Mika Kurkela, Mikko Neuvonen, Eeva Moilanen, Mikko Niemi, Aleksi Tornio, Janne T. Backman   +7 more
wiley   +1 more source

Interaction of CYP46A1 with CFH, LOC387715 and HTRA1 gene polymorphisms in age-related macular degeneration

, 2009
RésuméInternational audiencePurpose: To estimate the association and interaction of single nucleotide polymorphism (SNP) in cholesterol-24S-hydroxylase (CYP46A1) gene with HTRA1, LOC387715, CFH SNPs with age-related macular degeneration (AMD) in a North ...
Brétillon, Lionel, Martine, Lucy, Bjorkhem, Ingemar, Creuzot-Garcher, C., Dugas, Brice, Buteau, Bénédicte, Acar, Niyazi, Nicot, Frédéric, Bron, Alain, M., Fourgeux, Cynthia   +9 more
core   +2 more sources

Cholestérol-24S-hydroxylase (CYP46A1) et homéostasie du cholestérol dans la rétine en conditions physiologiques et pathologiques [PDF]

, 2012
Cholesterol is the major sterol found in the retina. In its free form, cholesterol is present in all cell layers of the retina, whereas cholesteryl esters mainly accumulate at the basement of the retinal pigment epithelium.
Fourgeux, Cynthia, Jaeger
core   +2 more sources

Elevated 24-hydroxycholesterol levels counteract okadaic acid-induced tau hyperphosphorylation and neuronal morphology impairment

Neurobiology of Disease
Multiple findings underline a link between altered brain cholesterol metabolism and Alzheimer's disease (AD) pathogenesis. Physiologically, excess brain cholesterol is mainly converted into 24-hydroxycholesterol (24-OHC) by the neuron-specific enzyme ...
Serena Giannelli, Francesca Eroli, Raúl Loera-Valencia, Valerio Leoni, Maria Latorre-Leal, Gabriella Testa, Erica Staurenghi, Barbara Sottero, Paola Gamba, Silvia Maioli, Gabriella Leonarduzzi   +10 more
doaj   +1 more source

Unilateral mastication‐induced memory deficits linked to disrupted hippocampal cholesterol metabolism in rats

VIEW, Volume 7, Issue 2, April 2026.
Unilateral mastication, a common oral habit, induces cognitive decline in rats by disrupting hippocampal cholesterol metabolism. It triggers astrocyte hyperplasia, enhances cholesterol synthesis, impairs transport/degradation, and reduces 24‐hydroxycholesterol (24‐OHC), ultimately damaging synaptic function.
Xiaoting Zhai, Yifan Hu, Rongchen Xu, Xinyu Xu, Bowen Ma, Dongzong Huang, Hongchen Liu, Hongbo Li, Yuan Hu, Hua Jiang   +9 more
wiley   +1 more source