Results 31 to 40 of about 1,473 (145)
Brain Sciences, 2022 Glucocorticoids are the most potent anti-inflammatory agents known. Limited in vivo data are available to characterize the mechanism underlying their cognitive side effects and transient occurrence of steroid psychosis.
Jelena Ciric +6 more
doaj +1 more source
Effect of Amyloid Beta on Cholesterol Metabolism-Correlated microRNAs in Primary Cultured Astrocytes of C57BL/6J Mice: A Focus on CYP46A1 and APOE Genes [PDF]
Cell JournalObjective: The accumulation of amyloid plaques and disturbance of cholesterol homeostasis are implicated in thepathophysiology of Alzheimer’s disease. Apolipoprotein E (ApoE) and cholesterol 24-hydroxylase (CYP46A1) are keyproteins involved in the efflux
Bahar Jaberian Asl +6 more
doaj +1 more source
Transcriptional regulation of the human CYP46A1 brain‐specific expression by Sp transcription factors [PDF]
Journal of Neurochemistry, 2008 AbstractBrain defective cholesterol homeostasis has been associated with neurologic diseases, such as Alzheimer’s and Huntington’s disease. The elimination of cholesterol from the brain involves its conversion into 24(S)‐hydroxycholesterol by CYP46A1, and the efflux of this oxysterol across the blood–brain barrier.
Milagre, I +6 more
openaire +4 more sources
Sex-dependent effects of CYP46A1 overexpression on cognitive function during aging [PDF]
, 2021 ABSTRACT Cholesterol turnover and CYP46A1 regulation are reported to be crucial for memory functions. An increasing body of evidence shows that CYP46A1 activation is able to reduce Alzheimer’s Disease (AD) pathological processes.
María Latorre-Leal +16 more
openaire +1 more source
Antifungal Azoles: Structural Insights into Undesired Tight Binding to Cholesterol-Metabolizing CYP46A1 [PDF]
Molecular Pharmacology, 2013 Although there are currently three generations of antifungal azoles on the market, even the third-generation agents show undesirable interactions with human cytochrome P450 (P450) enzymes. CYP46A1 is a cholesterol-metabolizing P450 in the brain that tightly binds a number of structurally distinct azoles. Previously, we determined the crystal structures
Natalia, Mast +3 more
openaire +2 more sources
PLoS Biology, 2023 Cholesterol contributes to neuronal membrane integrity, supports membrane protein clustering and function, and facilitates proper signal transduction. Extensive evidence has shown that cholesterol imbalances in the central nervous system occur in aging ...
Alejandro O Sodero +7 more
doaj +1 more source
Altered Cholesterol Homeostasis in Huntington’s Disease
Frontiers in Aging Neuroscience, 2022 Huntington’s disease (HD) is an autosomal dominant genetic disorder caused by an expansion of the CAG repeat in the first exon of Huntingtin’s gene.
Radhia Kacher +10 more
doaj +1 more source
Excitotoxicity increases the release of 24S-hydroxycholesterol via CYP46A1 activation [PDF]
Molecular Neurodegeneration, 2013 Background Excitotoxicity, a common hallmark of different neurological disorders including Alzheimer’s disease (AD), is the consequence of exacerbated neuronal stimulation and leads to a high influx of calcium trough membrane glutamate receptors [1]. On the other hand, high levels of the cholesterol metabolite 24S-hydroxycholesterol (24-HC) have been ...
Sodero, Alejandro +11 more
openaire +1 more source
Egyptian Journal of Medical Human Genetics, 2017 Background: Involvement of genetic factors like gene polymorphisms was found to contribute significantly to development and progression of Primary Open Angle Glaucoma (POAG) in the last few decades.
Syed Tasleem Raza +5 more
doaj +1 more source
The CH24H metabolite, 24HC, blocks viral entry by disrupting intracellular cholesterol homeostasis
Redox Biology, 2023 Cholesterol-24-hydroxylase (CH24H or Cyp46a1) is a reticulum-associated membrane protein that plays an irreplaceable role in cholesterol metabolism in the brain and has been well-studied in several neuro-associated diseases in recent years.
Yueming Yuan +12 more
doaj +1 more source