Results 31 to 40 of about 2,697 (198)

Increased Plasma Level of 24S-Hydroxycholesterol and Polymorphism of CYP46A1 SNP (rs754203) Are Associated With Mild Cognitive Impairment in Patients With Type 2 Diabetes

Frontiers in Aging Neuroscience, 2021
BackgroundAbnormal cholesterol metabolism is common in type 2 diabetes mellitus (T2DM) and causes dementia. Cholesterol 24S-hydroxylase (CYP46A1) converts cholesterol into 24S-hydroxycholesterol (24-OHC) and maintains cholesterol homeostasis in the brain.
Jijing Shi, Jijing Shi, Jianhong Jia, Sai Tian, Sai Tian, Haoqiang Zhang, Haoqiang Zhang, Ke An, Ke An, Wenwen Zhu, Wenwen Zhu, Wuyou Cao, Wuyou Cao, Yang Yuan, Shaohua Wang   +14 more
doaj   +1 more source

Polymorphism of CYP46A1 Gene and Alzheimer’s Disease in the Iranian Population [PDF]

Shiraz E-Medical Journal, 2016
Background: Cholesterol homeostasis in the brain has been demonstrated in the pathogenesis of Alzheimer’s disease (AD). Experimental data support that brain cholesterol turnover can modulate central processes in AD pathogenesis. Excess cholesterol is eliminated from the brain via hydroxylation mediated by cholesterol 24S-hydroxylase (CYP46A1), a main ...
Rohollah Mousavidehmordi, Hossain Babaahmadi, Bita Shalbafan, Ghorban Mohammadzadeh, Mohammadreza Afsharmanesh, Alireza Kheirollah   +5 more
openaire   +1 more source

Cholesterol 24S-Hydroxylase overexpression inhibits the liver X receptor (LXR) pathway by activating small guanosine triphosphate-binding proteins (sGTPases) in neuronal cells [PDF]

, 2014
The neuronal-specific cholesterol 24S-hydroxylase (CYP46A1) is important for brain cholesterol elimination. Cyp46a1 null mice exhibit severe deficiencies in learning and hippocampal long-term potentiation, suggested to be caused by a decrease in ...
Björkhem, Ingemar, Cedazo-Minguez, Angel, Gama, Maria João, Gomes, Anita Q., Moutinho, Miguel, Nunes, Maria João, Rodrigues, C. M., Rodrigues, Elsa   +7 more
core   +1 more source

24(S)-Hydroxycholesterol protects the ex vivo rat retina from injury by elevated hydrostatic pressure [PDF]

, 2016
In the central nervous system, 24(S)-hydroxycholesterol (24(S)-HC) is an oxysterol synthesized from cholesterol by cholesterol 24-hydroxylase (CYP46A1) encoded by the cyp46a1 gene.
Ishikawa, Makoto, Izumi, Yukitoshi, Yoshitomi, Takeshi, Zorumski, Charles F   +3 more
core   +3 more sources

Oral administration of repurposed drug targeting Cyp46A1 increases survival times of prion infected mice

Acta Neuropathologica Communications, 2021
Prion diseases are fatal, infectious, and incurable neurodegenerative disorders caused by misfolding of the cellular prion protein (PrPC) into the infectious isoform (PrPSc). In humans, there are sporadic, genetic and infectious etiologies, with sporadic
Tahir Ali, Samia Hannaoui, Satish Nemani, Waqas Tahir, Irina Zemlyankina, Pearl Cherry, Su Yeon Shim, Valerie Sim, Hermann M. Schaetzl, Sabine Gilch   +9 more
doaj   +1 more source

2-Hydroxypropyl-β-cyclodextrin mitigates pathological changes in a mouse model of retinal cholesterol dyshomeostasis

Journal of Lipid Research, 2023
CYP46A1 is a CNS-specific enzyme, which eliminates cholesterol from the brain and retina by metabolism to 24-hydroxycholesterol, thus contributing to cholesterol homeostasis in both organs.
Nicole El-Darzi, Natalia Mast, Sandra S. Hammer, Tim F. Dorweiler, Julia V. Busik, Irina A. Pikuleva   +5 more
doaj   +1 more source

Mitochondria-Associated Endoplasmic Reticulum Membranes as Potential Therapeutic Targets in Epilepsy. [PDF]

CNS Neurosci Ther
MAMs are involved in the occurrence and development of epilepsy through calcium ion homeostasis imbalance, mitochondrial dysfunction, endoplasmic reticulum stress and inflammation, abnormal lipid metabolism, as well as autophagy and mitochondrial autophagy. This picture was drawn using Figdraw.
Sun H, Li X, Zhao W, Zhang W, Meng H.
europepmc   +2 more sources

TSPO ligands promote cholesterol efflux and suppress oxidative stress and inflammation in choroidal endothelial cells [PDF]

, 2018
Choroidal endothelial cells supply oxygen and nutrients to retinal pigment epithelial (RPE) cells and photoreceptors, recycle metabolites, and dispose of metabolic waste through the choroidal blood circulation.
Bartholomew, Christopher, Biswas, Lincoln, Farhan, Fahad, Reilly, James, Shu, Xinhua   +4 more
core   +1 more source

The antifungal drug voriconazole is an efficient inhibitor of brain cholesterol 24S-hydroxylase in vitro and in vivo

Journal of Lipid Research, 2010
Cholesterol 24S-hydroxylase (CYP46A1) is of key importance for cholesterol homeostasis in the brain. This enzyme seems to be resistant toward most regulatory factors and at present no drug effects on its activity have been described.
Marjan Shafaati, Natalia Mast, Olof Beck, Rima Nayef, Gun Young Heo, Linda Björkhem-Bergman, Dieter Lütjohann, Ingemar Björkhem, Irina A. Pikuleva   +8 more
doaj   +1 more source

CYP46A1 activation by low-dose efavirenz enhances brain cholesterol metabolism in subjects with early Alzheimer’s disease

Alzheimer’s Research & Therapy, 2022
Background Efavirenz is an anti-HIV drug, and cytochrome P450 46A1 (CYP46A1) is a CNS-specific enzyme that metabolizes cholesterol to 24-hydroxycholesterol (24HC).
Alan J. Lerner, Steven E. Arnold, Erin Maxfield, Aaron Koenig, Maria E. Toth, Brooke Fortin, Natalia Mast, Bianca A. Trombetta, John Denker, Andrew A. Pieper, Curtis Tatsuoka, Sangeetha Raghupathy, Irina A. Pikuleva   +12 more
doaj   +1 more source