Results 31 to 40 of about 1,942 (152)

CYP46A1 activation by low-dose efavirenz enhances brain cholesterol metabolism in subjects with early Alzheimer’s disease

Alzheimer’s Research & Therapy, 2022
Background Efavirenz is an anti-HIV drug, and cytochrome P450 46A1 (CYP46A1) is a CNS-specific enzyme that metabolizes cholesterol to 24-hydroxycholesterol (24HC).
Alan J. Lerner, Steven E. Arnold, Erin Maxfield, Aaron Koenig, Maria E. Toth, Brooke Fortin, Natalia Mast, Bianca A. Trombetta, John Denker, Andrew A. Pieper, Curtis Tatsuoka, Sangeetha Raghupathy, Irina A. Pikuleva   +12 more
doaj   +1 more source

Targeting cytochrome P450 46A1 and brain cholesterol 24-hydroxylation to treat neurodegenerative diseases

Exploration of Neuroprotective Therapy, 2021
The brain cholesterol content is determined by the balance between the pathways of in situ biosynthesis and cholesterol elimination via 24-hydroxylation catalyzed by cytochrome P450 46A1 (CYP46A1). Both pathways are tightly coupled and determine the rate
Irina A. Pikuleva
doaj   +1 more source

Low-Dose Anti-HIV Drug Efavirenz Mitigates Retinal Vascular Lesions in a Mouse Model of Alzheimer’s Disease

Frontiers in Pharmacology, 2022
A small dose of the anti-HIV drug efavirenz (EFV) was previously discovered to activate CYP46A1, a cholesterol-eliminating enzyme in the brain, and mitigate some of the manifestation of Alzheimer’s disease in 5XFAD mice.
Nicole El-Darzi, Natalia Mast, David A. Buchner, Aicha Saadane, Brian Dailey, Georgios Trichonas, Irina A. Pikuleva   +6 more
doaj   +1 more source

Therapeutic rescue of NPC phenotype by CYP46A1 cerebellar expression [PDF]

, 2020
Niemann-Pick type C (NPC) disease is a rare neurogenerative disorder characterized by accumulation of cholesterol and other lipids in late endosomes/lysosomes.
Brito, Sara Filipa Correia de
core  

Effect of Amyloid Beta on Cholesterol Metabolism-Correlated microRNAs in Primary Cultured Astrocytes of C57BL/6J Mice: A Focus on CYP46A1 and APOE Genes [PDF]

Cell Journal
Objective: The accumulation of amyloid plaques and disturbance of cholesterol homeostasis are implicated in thepathophysiology of Alzheimer’s disease. Apolipoprotein E (ApoE) and cholesterol 24-hydroxylase (CYP46A1) are keyproteins involved in the efflux
Bahar Jaberian Asl, Zahra Nazeri, Seyadeh Pardis Pezeshki, Alireza Kheirollah, Shirin Azizidoost, Maryam Adelipour, Maryam Cheraghzadeh   +6 more
doaj   +1 more source

Food Restriction Counteracts Dexamethasone-Induced Downregulation of Genes Involved in Cholesterol Homeostasis in Rat Brain during Aging

Brain Sciences, 2022
Glucocorticoids are the most potent anti-inflammatory agents known. Limited in vivo data are available to characterize the mechanism underlying their cognitive side effects and transient occurrence of steroid psychosis.
Jelena Ciric, Vesna Tesic, Nikola Milovanovic, Irena Jovanovic Macura, Sanja Ivkovic, Selma Kanazir, Milka Perovic   +6 more
doaj   +1 more source

Chromatin-Modifying Agents Increase Transcription of CYP46A1, a Key Player in Brain Cholesterol Elimination

, 2010
The major mechanism of brain cholesterol elimination is the conversion of cholesterol into 24S-hydroxycholesterol by CYP46A1, a neuron-specific cytochrome P450.
Maria João Gama, Elsa Rodrigues, I. Milagre, Sigfrido Scarpa, Isabel Rivera, E. Rodrigues, Joao M. Nunes, Inês Milagre, Joao M. Gama, Miguel Moutinho, SCARPA, Sigfrido, Andrea Fuso, FUSO, ANDREA, Maria João Nunes, I. Rivera, M. Moutinho   +15 more
core   +1 more source

The Roles of EETs in Neurological Disorders

CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
Epoxyeicosatrienoic acids (EETs), derived from arachidonic acid (ARA) via cytochrome P450 (CYP450) enzymes, are produced in nearly all human tissues and exert a wide range of beneficial effects. This review summarizes the roles and potential mechanisms of EETs in neurological disorders, with a focus on cerebrovascular diseases, epilepsy, Parkinson's ...
Rong Tang, Mengya Li, Banglian Hu, Guoqiang Fei, Honghua Zheng, Xin Wang, Jing Ding   +6 more
wiley   +1 more source

Sex-dependent effects of CYP46A1 overexpression on cognitive function during aging

, 2021
Cholesterol turnover and CYP46A1 regulation are reported to be crucial for memory functions. An increasing body of evidence shows that CYP46A1 activation is able to reduce Alzheimer’s Disease (AD) pathological processes.
Eroli, F, Pacciarini, M, Zetterberg, H, Latorre-Leal, M, Kivipelto, M, Daniilidou, M, Franchini, L, Winblad, B, Blennow, K, Rodriguez-Rodriguez, P   +9 more
core   +1 more source

Phytosterols reverse antiretroviral-induced hearing loss, with potential implications for cochlear aging.

PLoS Biology, 2023
Cholesterol contributes to neuronal membrane integrity, supports membrane protein clustering and function, and facilitates proper signal transduction. Extensive evidence has shown that cholesterol imbalances in the central nervous system occur in aging ...
Alejandro O Sodero, Valeria C Castagna, Setiembre D Elorza, Sara M Gonzalez-Rodulfo, María A Paulazo, Jimena A Ballestero, Mauricio G Martin, María Eugenia Gomez-Casati   +7 more
doaj   +1 more source