Results 21 to 30 of about 2,697 (198)

Sterol imbalances and cholesterol-24-hydroxylase dysregulation is linked to the underlying progression of multiple sclerosis. [PDF]

Brain Pathol
We have sought to determine the role that cholesterol metabolism plays in disability worsening and its correlation with progressive MS by analysing patient CSF and post‐mortem tissues using cutting edge mass spectrometry approaches. Key sterol metabolites measured in the CSF link with important disability milestones at the very early stages of MS ...
Griffiths L, Hawkins K, Yutuc E, Angelini R, Fosuah R, Pacciarini M, Dickson A, Robertson N, Childs L, Loveless S, Tallantyre E, Griffiths WJ, Wang Y, Howell OW.   +13 more
europepmc   +2 more sources

Characterization of three naturally occurring lignans, sesamol, sesamolin, and sesamin, as potent inhibitors of human cytochrome P450 46A1: Implications for treating excitatory neurotoxicity

Frontiers in Pharmacology, 2022
CYP46A1 is a brain-specific enzyme responsible for cholesterol homeostasis. Inhibition of CYP46A1 activity serves as a therapeutic target for excitatory neurotoxicity.
Jie Du, Jie Du, Xiaodong Chen, Xiaodong Chen, Yongshun Zhao, Tingting Zhao, Tingting Zhao, Dalong Wang, Dalong Wang, Zujia Chen, Zujia Chen, Changyuan Wang, Changyuan Wang, Qiang Meng, Qiang Meng, Jialin Yao, Jialin Yao, Huijun Sun, Huijun Sun, Kexin Liu, Kexin Liu, Jingjing Wu, Jingjing Wu   +22 more
doaj   +1 more source

Neuronal Cholesterol Deficiency Mediated by Astrocytic SREBP2 Downregulation Leads to Postoperative Cognitive Dysfunction Through Impairment of Hippocampal Synaptic Plasticity and Excitatory Synaptic Transmission. [PDF]

Adv Sci (Weinh)
The results showed that the reduction of plasma 24‐hydroxycholesterol (24‐OHC) was related to the cognitive decline in elderly surgical patients. Neuroinflammation induced by anesthesia and surgery significantly downregulated SREBP2 in hippocampal reactive astrocytes, resulting in reduced cholesterol synthesis.
Huang H, Zhou C, Chen C, Tang H, Dong W, Wan J, Kang W, Sun A, Liu Y, Jin C, Lyu X, Zhu Y, Zhou C, Wu Y.   +13 more
europepmc   +2 more sources

Increased protein expression of ABCA1, HMG-CoA reductase, and CYP46A1 induced by garlic and allicin in the brain mouse and astrocytes-isolated from C57BL/6J [PDF]

Avicenna Journal of Phytomedicine, 2021
Objective: Regulation of cholesterol level is essential for the brain optimal function. The beneficial effect of garlic consumption on cholesterol homeostasis is well known; however, the molecular mechanism to support its properties is unclear.
Zahra Nazeri, Shirin Azizidoost, Maryam Cheraghzadeh, Asma Mohammadi, Alireza Kheirollah   +4 more
doaj   +1 more source

Transcriptional and post-translational changes in the brain of mice deficient in cholesterol removal mediated by cytochrome P450 46A1 (CYP46A1). [PDF]

PLoS ONE, 2017
Cytochrome P450 46A1 (CYP46A1) converts cholesterol to 24-hydroxycholesterol and thereby controls the major pathways of cholesterol removal from the brain.
Natalia Mast, Joseph B Lin, Kyle W Anderson, Ingemar Bjorkhem, Irina A Pikuleva   +4 more
doaj   +1 more source

Cholesterol Hydroxylating Cytochrome P450 46A1: From Mechanisms of Action to Clinical Applications

Frontiers in Aging Neuroscience, 2021
Cholesterol, an essential component of the brain, and its local metabolism are involved in many neurodegenerative diseases. The blood-brain barrier is impermeable to cholesterol; hence, cholesterol homeostasis in the central nervous system represents a ...
Irina A. Pikuleva, Nathalie Cartier
doaj   +1 more source

Brain cholesterol metabolism in Alzheimer's disease: Insights from ADNI and the UK BioBank [PDF]

Alzheimers Dement
Abstract Background Brain cholesterol metabolism plays a critical role in maintaining neuronal health and cognitive function. The CYP46A1 gene encodes cholesterol 24‐hydroxylase, which converts brain cholesterol to 24S‐hydroxycholesterol (24S‐HOC), a metabolite that can pass the blood brain barrier.
Ruthirakuhan M, Wong Y, Perfetto S, Xiong L, Wu C, Ryoo S, Mori‐Fegan D, Chenoweth M, Swardfager W.   +8 more
europepmc   +2 more sources

Localization of sterols and oxysterols in mouse brain reveals distinct spatial cholesterol metabolism [PDF]

, 2020
Dysregulated cholesterol metabolism is implicated in a number of neurological disorders. Many sterols, including cholesterol and its precursors and metabolites, are biologically active and important for proper brain function. However, spatial cholesterol
Angelini, Roberto, Baumert, Mark, Clench, Malcolm, Griffiths, William J., Howell, Owain W., Mast, Natalia, Newton, Jillian, Pikuleva, Irina, Skibinski, David O.F., Wang, Yuqin, Yutuc, Eylan   +10 more
core   +2 more sources

Bile Acid Profile Differs Between Brain Regions in Rodents and Is Disrupted in a Rodent Model of Alzheimer's Disease. [PDF]

Compr Physiol
We find that bile acid profile differs substantially between brain regions in mice and rats. However, differences in bile acid profile between brain regions are attenuated in a rat model of Alzheimer's disease. Together, these data demonstrate that both peripheral and central regulatory mechanisms maintain brain bile acid homeostasis, which is ...
Reuter MA, Moreno R, Agabao-Tucker ME, Shishani R, Bustamante JM, Marfori Z, Richieri T, Valenzuela AE, Taha AY, Lein PJ, Nandakumar R, Cummings BP.   +11 more
europepmc   +2 more sources

In vitro cytochrome P450 46A1 (CYP46A1) activation by neuroactive compounds [PDF]

Journal of Biological Chemistry, 2017
Cytochrome P450 46A1 (CYP46A1, cholesterol 24-hydroxylase) is the enzyme responsible for the majority of cholesterol elimination from the brain. Previously, we found that the anti-HIV drug efavirenz (EFV) can pharmacologically activate CYP46A1 in mice.
Natalia, Mast, Kyle W, Anderson, Kevin M, Johnson, Thanh T N, Phan, F Peter, Guengerich, Irina A, Pikuleva   +5 more
openaire   +2 more sources