Results 31 to 40 of about 2,904,339 (217)

24(S)-hydroxycholesterol participates in a liver X receptor-controlled pathway in astrocytes that regulates apolipoprotein E-mediated cholesterol efflux [PDF]

, 2006
Both apolipoprotein E (apoE) and 24(S)-hydroxycholesterol are involved in the pathogenesis of Alzheimer disease (AD). It has been hypothesized that apoE affects AD development via isoform-specific effects on lipid trafficking between astrocytes and ...
Ramaekers, FCS, Wellington, CL, Bakker, AHF, Mulder, M, Bakker, Arjen H. F., Ramaekers, F C S, Hirsch-Reinshagen, V., Ramaekers, F.C.S., Wellington, C L, Hirsch-Reinshagen, Veronica, Abildayeva, K, de Vente, J., Bloks, VW, Bakker, A.H.F., Bloks, V.W., Bakker, A H F, Groen, AK, Kuipers, F., Ramaekers, Frans C. S., Jansen, PJ, Mulder, M., de Vente, Jan, Abildayeva, Karlygash, Jansen, P J, Hirsch Reinshagen, V., Kuipers, F, Bloks, V W, Mulder, Monique, Groen, A K, Kuipers, F; id_orcid, Wellington, C.L., Kuipers, Folkert, Jansen, P.J., Abildayeva, K., Wellington, Cheryl L., Groen, A.K., Jansen, Paula J., de Vente, J, Groen, Albert K., Bloks, Vincent W.   +39 more
core   +1 more source

Cholesterol homeostasis in human brain: turnover of 24S-hydroxycholesterol and evidence for a cerebral origin of most of this oxysterol in the circulation

Journal of Lipid Research, 1998
We have previously demonstrated that the brain contains about 80% of the 24S-hydroxycholesterol in the human body and that there is a net flux of this steroid from the brain into the circulation (Lütjohann, D. et al. 1996. Proc. Natl. Acad. Sci. USA. 93:
Ingemar Björkhem, Dieter Lütjohann, Ulf Diczfalusy, Lars Ståhle, Gunvor Ahlborg, John Wahren   +5 more
doaj   +1 more source

High levels of (24S)-24-hydroxycholesterol 3-sulfate, 24-glucuronide in the serum and urine of children with severe cholestatic liver disease

Journal of Lipid Research, 1997
Extracts of urine and serum from children with cholestatic liver disease were analyzed by fast atom bombardment (FAB) mass spectrometry. About half of all spectra showed a peak at m/z 657, compatible with the presence of a glucuronidated cholestenediol ...
L J Meng, W J Griffiths, H Nazer, Y Yang, J Sjövall   +4 more
doaj   +1 more source

27-Hydroxycholesterol: production rates in normal human subjects

Journal of Lipid Research, 1999
We attempted to quantitate production of bile acid via the 27-hydroxylation pathway in six human subjects. After bolus intravenous injection of known amounts of [24-14C]cholic acid and [24-14C]chenodeoxycholic acid, each subject underwent a constant ...
William C. Duane, Norman B. Javitt
doaj   +1 more source

Side chain hydroxylation of cholesterol, campesterol and β-sitosterol in rat liver mitochondria

Journal of Lipid Research, 1976
The extent of the side chain hydroxylation of cholesterol, campesterol (24 α-methylcholesterol), and β-sitosterol (24 α-ethylcholesterol) in rat liver mitochondria has been compared.
L Aringer, P Eneroth, L Nordström
doaj   +1 more source

Metabolism of 27-, 25- and 24-hydroxycholesterol in rat glial cells and neurons [PDF]

Biochemical Journal, 1997
The metabolism of 27-, 25- and 24-hydroxycholesterol in cultures of rat astrocytes, Schwann cells and neurons was studied. 27- and 25-Hydroxycholesterol, but not 24-hydroxycholesterol, underwent 7α-hydroxylation with subsequent oxidation to 7α-hydroxy-3-oxo-Δ4 steroids in all three cell types.
J, Zhang, Y, Akwa, M, el-Etr, E E, Baulieu, J, Sjövall   +4 more
openaire   +2 more sources

Cholesterol 25-hydroxylation activity of CYP3A

Journal of Lipid Research, 2011
To date, many studies have been conducted using 25-hydroxycholesterol, which is a potent regulator of lipid metabolism. However, the origins of this oxysterol have not been entirely elucidated. Cholesterol 25-hydroxylase is one of the enzymes responsible
Akira Honda, Teruo Miyazaki, Tadashi Ikegami, Junichi Iwamoto, Tomomi Maeda, Takeshi Hirayama, Yoshifumi Saito, Tamio Teramoto, Yasushi Matsuzaki   +8 more
doaj   +1 more source

Reduction in Levels of 24S-Hydroxycholesterol by Statin Treatment in Patients With Alzheimer Disease [PDF]

Archives of Neurology, 2003
The statin treatment of dyslipidemia is associated with a reduced risk of development of Alzheimer disease (AD). The effect may be mediated by a reduction in cholesterol biosynthesis in the brain, by lowering levels of apolipoprotein E (apo E)-containing lipoproteins, or by pleitropic effects such as reduction in beta-amyloid production.
Gloria Lena, Vega, Myron F, Weiner, Anne M, Lipton, Klaus, Von Bergmann, Dieter, Lutjohann, Carol, Moore, Doris, Svetlik   +6 more
openaire   +2 more sources

Changes in the levels of cerebral and extracerebral sterols in the brain of patients with Alzheimer's disease

Journal of Lipid Research, 2004
24S-hydroxycholesterol is a side-chain oxidized oxysterol formed in the brain that is continuously crossing the blood-brain barrier to reach the circulation. There may be an opposite flux of 27-hydroxycholesterol, which is formed to a lower extent in the
Maura Heverin, Nenad Bogdanovic, Dieter Lütjohann, Thomas Bayer, Irina Pikuleva, Lionel Bretillon, Ulf Diczfalusy, Bengt Winblad, Ingemar Björkhem   +8 more
doaj   +1 more source

Plasma 24S-hydroxycholesterol (cerebrosterol) is increased in Alzheimer and vascular demented patients [PDF]

Journal of Lipid Research, 2000
Alzheimer's disease (AD) is characterized by the presence of senile plaques, neurofibrillary tangles, and neuronal cell loss associated with membrane cholesterol release. 24S-hydroxycholesterol (24S-OH-Chol) is an enzymatically oxidized product of cholesterol mainly synthesized in the brain. We tested the hypothesis that plasma levels of this oxysterol
Lütjohann, D., Papassotiropoulos, A., Björkhem, I., Locatelli, S., Bagli, M., Oehring, R. D., Schlegel, U., Jessen, F., Rao, M. L., von Bergmann, K., Heun, R.   +10 more
openaire   +3 more sources