Results 31 to 40 of about 13,032 (223)

Intronic CYP46 polymorphism along with ApoE genotype in sporadic Alzheimer Disease: from risk factors to disease modulators [PDF]

, 2004
Increasing biological and clinical findings argue for a link between brain cholesterol turnover and Alzheimer Disease (AD), high cerebral levels of the former increasing Abeta load.
AGOSTI C, AKKAWI N, ARCHETTI S, BORRONI, Barbara, BRAMBILLA C, CAIMI, Luigi, CALTAGIRONE C, DI LUCA M, PADOVANI, Alessandro   +8 more
core   +1 more source

High levels of (24S)-24-hydroxycholesterol 3-sulfate, 24-glucuronide in the serum and urine of children with severe cholestatic liver disease

Journal of Lipid Research, 1997
Extracts of urine and serum from children with cholestatic liver disease were analyzed by fast atom bombardment (FAB) mass spectrometry. About half of all spectra showed a peak at m/z 657, compatible with the presence of a glucuronidated cholestenediol ...
L J Meng, W J Griffiths, H Nazer, Y Yang, J Sjövall   +4 more
doaj   +1 more source

27-Hydroxycholesterol: production rates in normal human subjects

Journal of Lipid Research, 1999
We attempted to quantitate production of bile acid via the 27-hydroxylation pathway in six human subjects. After bolus intravenous injection of known amounts of [24-14C]cholic acid and [24-14C]chenodeoxycholic acid, each subject underwent a constant ...
William C. Duane, Norman B. Javitt
doaj   +1 more source

Cholesterol-Metabolizing Enzyme Cytochrome P450 46A1 as a Pharmacologic Target for Alzheimer’s Disease [PDF]

, 2017
Cytochrome P450 46A1 (CYP46A1 or cholesterol 24-hydroxylase) controls cholesterol elimination from the brain and plays a role in higher order brain functions.
Arajawa, Hiroyuki, Constans, James, Landreth, Gary, Li, Young, Mast, Natalia, Maxfield, Erin, Pikuleva, Irina A., Saadane, Aicha, Valencia-Olvera, Ana   +8 more
core   +1 more source

Multiplexed Tandem Mass Spectrometry Imaging Enables Large‐Scale Isomer Mapping and Annotation in Tissues

Angewandte Chemie, EarlyView.
Parallel mass spectrometry imaging acquires high mass resolution and tandem mass spectrometry images from 108 isolation windows in a single run. Spatial similarity networking clusters product ions by spatial distribution, enabling annotation of isomers and isobars as demonstrated for phospholipids and oxidized cholesterol in mouse and human brain ...
Varun V. Sharma, Gabor Toth, Robert Martinis, Cathrin E. Hansen, Gijs Kooij, Ingela Lanekoff   +5 more
wiley   +2 more sources

Side chain hydroxylation of cholesterol, campesterol and β-sitosterol in rat liver mitochondria

Journal of Lipid Research, 1976
The extent of the side chain hydroxylation of cholesterol, campesterol (24 α-methylcholesterol), and β-sitosterol (24 α-ethylcholesterol) in rat liver mitochondria has been compared.
L Aringer, P Eneroth, L Nordström
doaj   +1 more source

Amyloidogenicity and toxicity of the reverse and scrambled variants of amyloid-β 1-42 [PDF]

, 2017
β-amyloid 1-42 (Aβ1-42) is a self-assembling peptide that goes through many conformational and morphological changes before forming the fibrils that are deposited in extracellular plaques characteristic of Alzheimer's disease.
Gbajumo, Oyinkansola, Marshall, Karen E, Serpell, Louise C, Vadukul, Devkee M   +3 more
core   +1 more source

Cholesterol 25-hydroxylation activity of CYP3A

Journal of Lipid Research, 2011
To date, many studies have been conducted using 25-hydroxycholesterol, which is a potent regulator of lipid metabolism. However, the origins of this oxysterol have not been entirely elucidated. Cholesterol 25-hydroxylase is one of the enzymes responsible
Akira Honda, Teruo Miyazaki, Tadashi Ikegami, Junichi Iwamoto, Tomomi Maeda, Takeshi Hirayama, Yoshifumi Saito, Tamio Teramoto, Yasushi Matsuzaki   +8 more
doaj   +1 more source

Upregulation of brain renin angiotensin system by 27-hydroxycholesterol in Alzheimer's disease [PDF]

, 2011
In spite of the fact that cholesterol does not pass the blood-brain barrier, hypercholesterolemia has been linked to increase Alzheimer's disease (AD) risk.
Björkhem, I. (Ingemar), Cedazo-Minguez, A. (Ángel), Gil-Bea, F.J. (Francisco J.), Ismail, M.A. (Muhammad Al-Mustaf), Leoni, V. (Valerio), Mateos, L. (Laura), Winblad, B. (Bengt)   +6 more
core   +1 more source

Changes in the levels of cerebral and extracerebral sterols in the brain of patients with Alzheimer's disease

Journal of Lipid Research, 2004
24S-hydroxycholesterol is a side-chain oxidized oxysterol formed in the brain that is continuously crossing the blood-brain barrier to reach the circulation. There may be an opposite flux of 27-hydroxycholesterol, which is formed to a lower extent in the
Maura Heverin, Nenad Bogdanovic, Dieter Lütjohann, Thomas Bayer, Irina Pikuleva, Lionel Bretillon, Ulf Diczfalusy, Bengt Winblad, Ingemar Björkhem   +8 more
doaj   +1 more source