Results 51 to 60 of about 2,904,339 (217)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Plasma 24S-hydroxycholesterol and caudate MRI in pre-manifest and early Huntington's disease [PDF]

Brain, 2008
Huntington's disease (HD) is a hereditary neurodegenerative disorder for which biological indicators of disease progression, or disease stage, would be especially important for therapeutic trials. 24S-hydroxycholesterol (24OHC) is a brain-generated cholesterol metabolite which has been associated with neurodegeneration, and alterations of cholesterol ...
V. Leoni, C. Mariotti, S. J. Tabrizi, M. Valenza, E. J. Wild, S. M. Henley, N. Z. Hobbs, M. L. Mandelli, M. Grisoli, I. Bjorkhem, E. Cattaneo, S. Di Donato   +11 more
openaire   +4 more sources

Metabolism of 4 beta -hydroxycholesterol in humans

, 2002
One of the major oxysterols in the human circulation is 4 beta-hydroxycholesterol formed from cholesterol by the drug-metabolizing enzyme cytochrome P450 3A4.
Björkhem, Ingemar, Norlin, Maria,, Diczfalusy, Ulf, Andersson, Ulla, Eggertsen, Gösta, Rystedt, Eva, Ellis, Eva, Bodin, Karl, Pikuleva, Irina   +8 more
core   +1 more source

On the substrate specificity of human CYP27A1

Journal of Lipid Research, 2003
The mitochondrial sterol 27-hydroxylase (CYP27A1) is required for degradation of the C27-sterol side chain in bile acid biosynthesis. CYP27A1 seems, however, to have roles beyond this, as illustrated by patients with a deficient sterol 27-hydroxylase due
Maria Norlin, Sara von Bahr, Ingemar Björkhem, Kjell Wikvall   +3 more
doaj   +1 more source

Extracellular Vesicle‐Transferred ATP‐Citrate Lyase Induces Monocyte Differentiation Toward Tumor‐Associated Macrophages and Fuels Hepatocellular Carcinoma Progression

Advanced Science, EarlyView.
Hepatocellular carcinoma (HCC)‐derived extracellular vesicles (EVs) enrich the metabolic enzyme ATP‐citrate lyase (ACLY). EV‐transferred ACLY enhances palmitate biosynthesis, increases the S‐palmitoylation and stability of multiple immune checkpoint proteins, augments the cellular immunosuppressive activity, and ultimately accelerates the malignant ...
Zhijun Liu, Haihong Lai, Qing Yang, Chaoyue Zhang, Bin Jia, Qiyi Chen, Yuling Deng, Fen Cao, Yuyu You, Zhe Li, Dongming Kuang, Bo Li   +11 more
wiley   +1 more source

In vivo formation of 25-hydroxycholesterol from endogenous cholesterol after a single meal, dietary cholesterol challenge.

Journal of Lipid Research, 1994
The role of oxysterols as regulatory molecules in the suppression of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase activity was investigated in the intact rat in response to an acute dietary cholesterol challenge.
K A Johnson, C J Morrow, G D Knight, T J Scallen   +3 more
doaj   +1 more source

Palmitic Acid Promotes Antiviral Innate Immunity via ZDHHC20‐Mediated CMPK2 Palmitoylation

Advanced Science, EarlyView.
Metabolites have important functions in innate immune activation and regulation. Wang et al. uncover metabolic regulation of antiviral immunity through CMPK2 palmitoylation, which regulates CMPK2 mitochondrial localization and is promoted by ZDHHC20 but reversed by PPT1, inhibition of which antagonizes viral infection in mice.
Yujia Wang, Zenghui Cui, Yunkai Zhang, Zhiqing Li, Xuetao Cao   +4 more
wiley   +1 more source

Modulation of Muller cell membrane organization by 24S‐hydroxycholesterol

Acta Ophthalmologica, 2017
PurposeMuller glial cells (MGC) are involved in the retinal homeostasis and they are sustaining cholesterol homeostasis. A lack or an excess of cholesterol in neurons can cause neuro‐degeneration. Cholesterol is eliminated from the retina mainly as 24S‐hydroxycholesterol (24S‐OHC).
P.H. Gabrielle, S. Gambert, E. Masson, E. Leger‐Charnay, A. Ferrerro, A. Vannier, C. Gendrault, M. Lachot, C. Creuzot‐Garcher, A. Bon, S. Gregoire, L. Leclere, L. Martine, G. Lucchi, C. Truntzer, L. Bretillon   +15 more
openaire   +1 more source

Excitotoxicity increases the release of 24S-hydroxycholesterol via CYP46A1 activation [PDF]

Molecular Neurodegeneration, 2013
Background Excitotoxicity, a common hallmark of different neurological disorders including Alzheimer’s disease (AD), is the consequence of exacerbated neuronal stimulation and leads to a high influx of calcium trough membrane glutamate receptors [1]. On the other hand, high levels of the cholesterol metabolite 24S-hydroxycholesterol (24-HC) have been ...
Sodero, Alejandro, Vriens, Joris, Ghosh, Debapriya, Stegner, David, Brachet, Anna, Pallotto, Marta, Sassoe-Pognetto, Marco, Brouwers, Jos, Helms, Bernd, Nieswandt, Bernard, Voets, Thomas, Dotti, Carlos   +11 more
openaire   +1 more source

Cholesterol‐Mediated Metabolic‐mechanotransductive Crosstalk Orchestrates Castration Resistance in Prostate Cancer

Advanced Science, EarlyView.
Full androgen deprivation (FAD) induces paracrine cholesterol in prostate cancer that drives the polarization of cancer‐associated fibroblasts (CAFs) and subsequent elevated matrix stiffness. Matrix stiffness in turn potentiates tumor cell survival under FAD pressure via dual mechanotransductive activation of the IRE1α‐XBP1s stress‐response axis ...
Shaojie Liu, Chao Xu, Jun Jiang, Limin He, Yike Zhou, Zhengxuan Li, Yu Li, Keying Zhang, Fa Yang, Tong Lu, Hongtao Song, Hai Zhu, Zhihao Hu, Xiaolong Zhao, Kai Gan, Hongji Li, Bo Yang, Rui Zhang, Weihong Wen, Donghui Han, Weijun Qin   +20 more
wiley   +1 more source