Results 51 to 60 of about 13,032 (223)
Separations, 2018 Oxysterols are metabolites produced in the first step of cholesterol metabolism, which is related to neurodegenerative disorder. They can be detected by testing blood, plasma, serum, or cerebrospinal fluid.
Lucia Valverde-Som +7 more
doaj +1 more source
A quantitative LC-MS/MS method for analysis of mitochondrial -specific oxysterol metabolism
Redox Biology, 2020 Oxysterols are critical regulators of inflammation and cholesterol metabolism in cells. They are oxidation products of cholesterol and may be differentially metabolised in subcellular compartments and in biological fluids.
Khushboo Borah +8 more
doaj +1 more source
24(S)-Hydroxycholesterol protects the ex vivo rat retina from injury by elevated hydrostatic pressure [PDF]
, 2016 In the central nervous system, 24(S)-hydroxycholesterol (24(S)-HC) is an oxysterol synthesized from cholesterol by cholesterol 24-hydroxylase (CYP46A1) encoded by the cyp46a1 gene.
Ishikawa, Makoto +3 more
core +3 more sources
Targeting cholesterol homeostasis to fight hearing loss: a new perspective. [PDF]
, 2015 Sensorineural hearing loss (SNHL) is a major pathology of the inner ear that affects nearly 600 million people worldwide. Despite intensive researches, this major health problem remains without satisfactory solutions.
de Medina, Philippe +3 more
core +5 more sources
Journal of Lipid Research, 2014 Iso-octyl chain-hydroxylated oxysterols were determined in attomoles per 10,000 cells concentrations in 10,000–80,000 cultured pancreatic adenocarcinoma cells, using a sensitive, highly automated nano-LC-ESI-MS-based method.
Hanne Roberg-Larsen +9 more
doaj +1 more source
Journal of Lipid Research, 2023 CYP46A1 is a CNS-specific enzyme, which eliminates cholesterol from the brain and retina by metabolism to 24-hydroxycholesterol, thus contributing to cholesterol homeostasis in both organs.
Nicole El-Darzi +5 more
doaj +1 more source
The major brain cholesterol metabolite 24(s)-hydroxycholesterol is a potent allosteric modulator of N-methyl-d-aspartate receptors [PDF]
, 2013 N-methyl-d-aspartate receptors (NMDARs) are glutamate-gated ion channels that are critical to the regulation of excitatory synaptic function in the CNS.
Belfort, Gabriel M +11 more
core +2 more sources
Nuclear Receptors as Therapeutic Targets for Neurodegenerative Diseases: Lost in Translation [PDF]
, 2019 Neurodegenerative diseases are characterized by a progressive loss of neurons that leads to a broad range of disabilities, including severe cognitive decline and motor impairment, for which there are no effective therapies.
Codocedo, Juan F. +3 more
core +1 more source
Plasma 24S-hydroxycholesterol (cerebrosterol) is increased in Alzheimer and vascular demented patients [PDF]
Journal of Lipid Research, 2000 Alzheimer's disease (AD) is characterized by the presence of senile plaques, neurofibrillary tangles, and neuronal cell loss associated with membrane cholesterol release. 24S-hydroxycholesterol (24S-OH-Chol) is an enzymatically oxidized product of cholesterol mainly synthesized in the brain. We tested the hypothesis that plasma levels of this oxysterol
Lütjohann, D. +10 more
openaire +4 more sources
Lipid peroxidation biomarkers for evaluating oxidative stress in equine neuroaxonal dystrophy. [PDF]
, 2018 BackgroundEquine neuroaxonal dystrophy/equine degenerative myeloencephalopathy (eNAD/EDM) is a neurodegenerative disorder affecting genetically predisposed foals maintained on an α-tocopherol (α-TOH) deficient diet.
Bordbari, Matthew H +9 more
core