Results 51 to 60 of about 4,101,858 (162)

Studies on the oxysterols 4alpha- and 4beta-hydroxycholesterol

, 2011
Cytochrome P450 (CYP) enzymes catalyze the metabolism of both foreign and endogenous substances such as drugs and steroids. Enzymes in subfamily CYP3A sum up to 30% of the total CYP content in the liver and metabolize about 50% of all drugs.
Hanna Nylén (18685588)
core   +1 more source

The Oral‐Hepatic Axis: Epidemiological and Mechanistic Links Between Periodontal and Liver Diseases

Journal of Periodontal Research, EarlyView.
This review summarizes current epidemiological, clinical and mechanistic evidence linking periodontitis and chronic liver diseases, highlighting the oral‐gut‐liver axis, shared immunometabolic and nutritional pathways and opportunities for integrated preventive and therapeutic strategies.
Sinem Esra Sahingur, Kinga Grzech‐Leśniak, Samuel F. Suslavich, Janina Golob Deeb   +3 more
wiley   +1 more source

The Impact of Brain Cholesterol (24-hydroxycholesterol (24-HC) and 27- hydroxycholesterol (27-HC)) on Invitro Phenotypes of Brain Metastatic Breast Cancer Cells [PDF]

Introduction: Brain metastases is one of the leading causes of breast cancer mortality and rates continue to increase. It has been previously shown that cholesterol metabolism is an important regulator of cancer progression.
Iroabuchi, Cherish
core   +3 more sources

A Japanese prospective multicenter study of urinary oxysterols in biliary atresia

Scientific Reports, 2021
Diagnosis of biliary atresia (BA) can involve uncertainties. In the present prospective multicenter study, we considered whether urinary oxysterols represent a useful marker for diagnosis of BA in Japanese children.
Ken-ichiro Konishi, Tatsuki Mizuochi, Hajime Takei, Ryosuke Yasuda, Hirotaka Sakaguchi, Jun Ishihara, Yugo Takaki, Masahiro Kinoshita, Naoki Hashizume, Suguru Fukahori, Hiromichi Shoji, Go Miyano, Koichiro Yoshimaru, Toshiharu Matsuura, Yukihiro Sanada, Takahisa Tainaka, Hiroo Uchida, Yumiko Kubo, Hiromu Tanaka, Hideyuki Sasaki, Tsuyoshi Murai, Jun Fujishiro, Yushiro Yamashita, Masaki Nio, Hiroshi Nittono, Akihiko Kimura   +25 more
doaj   +1 more source

Epigenomic Cascades Across Organs in Metabolic Dysfunction–Associated Steatotic Liver Disease: New Therapeutic Horizons

Obesity Reviews, EarlyView.
ABSTRACT Metabolic dysfunction–associated steatotic liver disease (MASLD) is the most common chronic liver disorder worldwide, affecting approximately one‐third of the population and increasing the risk of severe hepatic and cardiovascular complications.
Shurui Yang, Zhongyu Huang, Sanchun Tan, Fengxia Liang, Li Chen   +4 more
wiley   +1 more source

Targeting cytochrome P450 46A1 and brain cholesterol 24-hydroxylation to treat neurodegenerative diseases

Exploration of Neuroprotective Therapy, 2021
The brain cholesterol content is determined by the balance between the pathways of in situ biosynthesis and cholesterol elimination via 24-hydroxylation catalyzed by cytochrome P450 46A1 (CYP46A1). Both pathways are tightly coupled and determine the rate
Irina A. Pikuleva
doaj   +1 more source

Leptin–cholesterol crosstalk in pregnancy: Mechanistic implications for placental function and cardiometabolic programming

Experimental Physiology, EarlyView.
Abstract Pregnancy requires the coordinated maternal reorganization of lipid and endocrine pathways to sustain fetal growth and anticipate neonatal nutrition. Leptin, produced by adipose tissue and the placenta, acts as an integrative signal linking maternal energy status with trophoblast function and vascular adaptation, while cholesterol provides ...
Julio Flores, Diego Gumera, Andreina Arias, Cristián A. Amador, María José Yañez   +4 more
wiley   +1 more source

Biotin attenuation of oxidative stress, mitochondrial dysfunction, lipid metabolism alteration and 7β-hydroxycholesterol-induced cell death in 158N murine oligodendrocytes

, 2019
Mitochondrial dysfunction and oxidative stress are involved in neurodegenerative diseases associated with an enhancement of lipid peroxidation products such as 7β-hydroxycholesterol (7β-OHC).
Ilham Badreddine (6838493), Claudio Caccia (87835), Mustapha Cherkaoui-Malki (618942), Mohammad Samadi (3028275), Valerio Leoni (440542), Gérard Lizard (3300573), Anne Vejux (6838502), Thomas Nury (6838490), Boubker Nasser (779666), Amira Zarrouk (6838487), Thibault Moreau (765638), Ahmed Salhedine Masmoudi (6838505), Randa Sghaier (6838484), Nora O’Brien (6838496), John J. Mackrill (6838499)   +14 more
core   +1 more source

Molecular basis for the recognition of 24-(S)-hydroxycholesterol by integrin αvβ3

Scientific Reports, 2023
A growing body of evidence suggests that oxysterols such as 25-hydroxycholesterol (25HC) are biologically active and involved in many physiological and pathological processes.
Jeevan B. Gc, Justin Chen, Swechha M. Pokharel, Indira Mohanty, Charles Mariasoosai, Peter Obi, Paul Panipinto, Smarajit Bandyopadhyay, Santanu Bose, Senthil Natesan   +9 more
doaj   +1 more source

Hepatic uptake and metabolism of ingested 24-hydroxycholesterol and 24(S),25-epoxycholesterol.

, 1993
Although two hepatic sterol metabolites, 24(S)-hydroxycholesterol and 24(S),25-epoxycholesterol, are thought to be important regulators of cholesterol biosynthesis, nothing is known of their degradation and disposal in liver, nor of the mechanisms ...
Kandutsch, A A, Spencer, T A, Clark, D S, Saucier, S E   +3 more
core   +1 more source