Results 71 to 80 of about 13,032 (223)

Serum 24S-hydroxycholesterol and hippocampal size in middle-aged normal individuals

Neurobiology of Aging, 2009
The present study assessed the association between serum 24S-hydroxycholesterol (24S-OH-Chol) and 27-hydroxycholesterol (27-OH-Chol) and hippocampal volumes in 69 middle-aged cognitively normal individuals. Results showed that subjects with high levels of oxysterols had significantly larger hippocampal volumes than subjects with low levels of ...
Koschack, Janka, Luetjohann, Dieter, Schmidt-Samoa, Carsten, Irle, Eva   +3 more
openaire   +3 more sources

Quantification and Localisation of New Brain Lipid Synthesis Using Deuterium Oxide and High Resolution Mass Spectrometry

Angewandte Chemie, Volume 138, Issue 18, 27 April 2026.
Liquid chromatography tandem mass spectrometry and mass spectrometry imaging were used in combination with deuterium oxide administration to quantify and localise newly synthesised myelin lipids in the mouse brain. This methodology, used here to show sites of myelin repair, enables the measurement of dynamic lipid synthesis in living systems and ...
Catherine Zhang, Jesse A. Michael, Jonathan D. Teo, Huitong Song, Mika T. Westerhausen, Shadrack M. Mutuku, Shane R. Ellis, Anthony S. Don   +7 more
wiley   +2 more sources

Simultaneous determination of oxysterols, cholesterol and 25-hydroxy-vitamin D3 in human plasma by LC-UV-MS. [PDF]

PLoS ONE, 2015
Oxysterols are promising biomarkers of neurodegenerative diseases that are linked with cholesterol and vitamin D metabolism. There is an unmet need for methods capable of sensitive, and simultaneous quantitation of multiple oxysterols, vitamin D and ...
Rohini Narayanaswamy, Vignesh Iyer, Prachi Khare, Mary Lou Bodziak, Darlene Badgett, Robert Zivadinov, Bianca Weinstock-Guttman, Todd C Rideout, Murali Ramanathan, Richard W Browne   +9 more
doaj   +1 more source

Role of platelet-derived growth factor B in cholesterol and glucose metabolism [PDF]

, 2017
Platelet-derived growth factor (PDGFB) is a critical molecule for recruiting pericytes. Due to the fundamental role of the pericytes in angiogenesis and vascular stability, PDGFB knockout mice die perinatally from severe hemorrhage and edema.
Li, Tian
core   +1 more source

Metabolism of 27-, 25- and 24-hydroxycholesterol in rat glial cells and neurons [PDF]

Biochemical Journal, 1997
The metabolism of 27-, 25- and 24-hydroxycholesterol in cultures of rat astrocytes, Schwann cells and neurons was studied. 27- and 25-Hydroxycholesterol, but not 24-hydroxycholesterol, underwent 7α-hydroxylation with subsequent oxidation to 7α-hydroxy-3-oxo-Δ4 steroids in all three cell types.
J, Zhang, Y, Akwa, M, el-Etr, E E, Baulieu, J, Sjövall   +4 more
openaire   +2 more sources

Soticlestat as an adjunctive therapy in children and young adults with Dravet syndrome

Epilepsia, EarlyView.
Overview of the phase 3 trial evaluating soticlestat as adjunctive therapy in children and young adults with Dravet syndrome. Abstract Objective This study evaluated the efficacy, safety, and tolerability of soticlestat as adjunctive therapy in children and young adults with Dravet syndrome (DS).
Joseph Sullivan, Kette Valente, Vicente Villanueva, Adam Strzelczyk, Rima Nabbout, Eiji Nakagawa, Yuehua Zhang, Marta Zolnowska, Yasir Khan, Cheng Dong, Samuel Hsiao, Sarah I. Sheikh, Philipp von Rosenstiel, Mahnaz Asgharnejad, Venkatesha Murthy   +14 more
wiley   +1 more source

Molecular basis for the recognition of 24-(S)-hydroxycholesterol by integrin αvβ3

Scientific Reports, 2023
A growing body of evidence suggests that oxysterols such as 25-hydroxycholesterol (25HC) are biologically active and involved in many physiological and pathological processes.
Jeevan B. Gc, Justin Chen, Swechha M. Pokharel, Indira Mohanty, Charles Mariasoosai, Peter Obi, Paul Panipinto, Smarajit Bandyopadhyay, Santanu Bose, Senthil Natesan   +9 more
doaj   +1 more source

Role of necroptosis in the pathogenesis of solid organ injury [PDF]

, 2015
Necroptosis is a type of regulated cell death dependent on the activity of receptor-interacting serine/threonine-protein (RIP) kinases. However, unlike apoptosis, it is caspase independent.
Eguchi, S, Jaffer, T, Linkermann, A, Ma, D, Wang, Z, Zhao, H   +5 more
core   +1 more source

Cholesterol and oxysterol sulfates:Pathophysiological roles and analytical challenges [PDF]

, 2021
Cholesterol and oxysterol sulfates are important regulators of lipid metabolism, inflammation, cell apoptosis, and cell survival. Among the sulfate-based lipids, cholesterol sulfate (CS) is the most studied lipid both quantitatively and functionally ...
Aleksandrov D. A., Ana Reis, Björkhem I., Drayer N. M., Honke K., Irundika H.K. Dias, Ito N., Iwamori M., Kallen J., Kong A. N., Lissette Carolina Sanchez‐Aranguren, Lopalco P., Lorena Diaz Sanchez, Lorenzo Pontini, Maura Marinozzi, Meng L. J., Merten M., Muskiet F. A., Nakagawa M., Nardi A., Otterness D. M., Rizner T. L., Sato J., Yang Z.   +23 more
core   +1 more source

A phase 3, randomized clinical trial of soticlestat as adjunctive therapy for Lennox–Gastaut syndrome

Epilepsia, EarlyView.
Soticlestat as adjunctive therapy for Lennox–Gastaut syndrome. Abstract Objective There remains a need for new treatments for Lennox–Gastaut syndrome (LGS), a developmental and epileptic encephalopathy with a heterogenous patient population that often requires polytherapy. The phase 3, randomized SKYWAY study (NCT04938427) investigated the efficacy and
Renzo Guerrini, Eric D. Marsh, Wei‐Ping Liao, Katsumi Imai, Ruzica Kravljanac, Anna Altmann, Cecil D. Hahn, Stéphane Auvin, Jimmy Schiemann, Yasir Khan, Pranab Mitra, Sarah I. Sheikh, Philipp von Rosenstiel, Mahnaz Asgharnejad, Dennis Dlugos, Venkatesha Murthy   +15 more
wiley   +1 more source