Results 71 to 80 of about 4,101,858 (162)

Cerebrospinal Fluid 24(S)-hydroxycholesterol levels post intrathecal adrabetadex infusion

Cerebrospinal fluid 24(S)-hydroxycholesterol levels pre administration and 48 hours after intrathecal administration of adrabetadex (2-hydroxypropyl-B-cyclodextrin.
Porter, Forbes
core   +1 more source

Serum VIP and IL‐1β Levels Are Associated With Anxiety and Depression in Patients With Parkinson's Disease: A Cross‐Sectional Study

Brain and Behavior, Volume 16, Issue 9, September 2026.
ABSTRACT Background Anxiety and depressive symptoms frequently accompany Parkinson's disease (PD), yet the biological processes underlying these affective complications and their potential peripheral indicators remain incompletely understood. This study evaluated whether circulating concentrations of vasoactive intestinal peptide (VIP), interleukin‐1β (
Liangyu Li, Xiaoyang Jia, Ying Shi, Zexin Yuan, Caoyuan Niu, Yujing Huang, Xiaoli Zhang, Honglei Li, Tiantian Han, Yanji Cui, Pengge Fei, Guihua Wang, Ailing Du   +12 more
wiley   +1 more source

Oxysterols and apolipoproteins in multiple sclerosis: a 5 year follow-up study[S]

Journal of Lipid Research, 2019
The purpose of this work was to investigate whether changes in oxysterol and apolipoprotein levels over 5 years are associated with disease course and disability progression in multiple sclerosis (MS).
Kelly Fellows Maxwell, Sonia Bhattacharya, Mary Lou Bodziak, Dejan Jakimovski, Jesper Hagemeier, Richard W. Browne, Bianca Weinstock-Guttman, Robert Zivadinov, Murali Ramanathan   +8 more
doaj   +1 more source

Targeting the GPR183/EBI2‒oxysterol axis in tuberculosis: Immunometabolic regulation and prospects for host‐directed therapy

Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.
GPR183/EBI2 links oxysterol metabolism with immune‐cell positioning and macrophage function in tuberculosis. The 7α,25‐OHC‐GPR183 axis regulates macrophage trafficking, autophagy and type I interferon responses. GPR183 represents a potential immunometabolic target for host‐directed therapy against tuberculosis..
Junfei Wang, Yingnan Zhou, Xunming Ji, Haiping Zhao, Lingjun Zhan   +4 more
wiley   +1 more source

Bile acid metabolism and signaling in human and animal health: A One Health perspective

iMetaOmics, Volume 3, Issue 3, September 2026.
Bile acids maintain host homeostasis through enterohepatic circulation, microbial transformation, and bile acid receptor signaling, thereby regulating glucose and lipid metabolism, intestinal barrier integrity, and immunity. These effects support human disease intervention and health‐oriented animal production, reducing drug dependence and residue ...
Lei Li, Shuai Liu, Zhijun Cao, Yangchun Cao, Shengru Wu, Lu Deng, Junhu Yao, Jun Zhang   +7 more
wiley   +1 more source

24-Hydroxycholesterol is a substrate for hepatic cholesterol 7 alpha-hydroxylase (CYP7A)

, 2000
(24S)-Hydroxycholesterol is formed from cholesterol in the brain and is important for cholesterol homeostasis in this organ. Elimination of (24S)-hydroxycholesterol has been suggested to occur in the liver but little is known about the metabolism of this
Toll, Anders,, Bjorkhem, Ingemar, Wikvall, Kjell,, Norlin, Maria,   +3 more
core  

Cholesterol

Journal of Lipid Research, 2003
The accumulation and aggregation of the amyloid-β peptide (Aβ) in the brain are important contributing factors to Alzheimer's disease (AD). Consequently, blocking the generation of Aβ is a potentially important treatment strategy.
Robert L. Raffaï, Karl H. Weisgraber
doaj   +1 more source

Biomimetic mineralization‐inspired formulation‐adjuvant integrated circRNA nanovaccine against COVID‐19

Interdisciplinary Medicine, Volume 4, Issue 5, September 2026.
Inspired by the role of Mg2+ in stabilizing RNA secondary structures, we developed a one‐pot biomimetic mineralization method for synthesizing a circular RNA‐based nanovaccine (circRNA@FAiNVac) that integrates formulation and adjuvant functions. This nanovaccine exhibits potent immunostimulatory activation enabling multimodal immune responses and ...
Liangru Lin, Yingying Ren, Jing Li, Panxing Ren, Xinran Wang, Yixin Ding, Linsu Liu, Cong Liu, Zhou Li, Yan Liu, Dan Luo   +10 more
wiley   +1 more source

Changes in brain oxysterols at different stages of Alzheimer's disease: Their involvement in neuroinflammation

Redox Biology, 2016
Alzheimer's disease (AD) is a gradually debilitating disease that leads to dementia. The molecular mechanisms underlying AD are still not clear, and at present no reliable biomarkers are available for the early diagnosis.
Gabriella Testa, Erica Staurenghi, Chiara Zerbinati, Simona Gargiulo, Luigi Iuliano, Giorgio Giaccone, Fausto Fantò, Giuseppe Poli, Gabriella Leonarduzzi, Paola Gamba   +9 more
doaj   +1 more source

Identification of regulatory oxysterols, 24(S),25-epoxycholesterol and 25-hydroxycholesterol, in cultured fibroblasts.

, 1985
Biosynthetically tritiated sterols from Chinese hamster lung (Dede) cells were fractionated by high performance liquid chromatography, and fractions were assayed for their ability to repress 3-hydroxy-3-methylglutaryl-CoA reductase in L cell cultures.
Kandutsch, A A, Gayen, A K, Spencer, T A, Saucier, S E, Phirwa, S, Taylor, F R   +5 more
core   +1 more source