Results 91 to 100 of about 2,904,339 (217)

24(S)-Hydroxycholesterol protects the ex vivo rat retina from injury by elevated hydrostatic pressure

, 2016
In the central nervous system, 24(S)-hydroxycholesterol (24(S)-HC) is an oxysterol synthesized from cholesterol by cholesterol 24-hydroxylase (CYP46A1) encoded by the cyp46a1 gene.
Ishikawa, Makoto, Yoshitomi, Takeshi, Zorumski, CharlesF., Izumi, Yukitoshi   +3 more
core   +2 more sources

Oxysterols and apolipoproteins in multiple sclerosis: a 5 year follow-up study[S]

Journal of Lipid Research, 2019
The purpose of this work was to investigate whether changes in oxysterol and apolipoprotein levels over 5 years are associated with disease course and disability progression in multiple sclerosis (MS).
Kelly Fellows Maxwell, Sonia Bhattacharya, Mary Lou Bodziak, Dejan Jakimovski, Jesper Hagemeier, Richard W. Browne, Bianca Weinstock-Guttman, Robert Zivadinov, Murali Ramanathan   +8 more
doaj   +1 more source

Metabolic Regulation of Immune Responses: Molecular Mechanisms, Diseases, and Therapeutic Targets

MedComm, Volume 7, Issue 6, June 2026.
FBP1 loss drives immune evasion and therapy resistance by enhancing glycolysis, STAT3 activation, and PD‐L1 expression, leading to T cell exhaustion and NK cell inhibition. FBP1 restoration, via LNP‐mRNA or epigenetic modulation, reverses these immunosuppressive effects, reactivates cytotoxic T cells, promotes M1 macrophage polarization, and enhances ...
Chunwei Li, Ziqiang Liu, Dezheng Kong, Zhengze Li, Yiming Yan, Yanyu Dong, Lili Zhu, JiaNing Cao, Zhirui Fan, Gautam Sethi, Lifeng Li   +10 more
wiley   +1 more source

24-Hydroxycholesterol is a substrate for hepatic cholesterol 7 alpha-hydroxylase (CYP7A)

, 2000
(24S)-Hydroxycholesterol is formed from cholesterol in the brain and is important for cholesterol homeostasis in this organ. Elimination of (24S)-hydroxycholesterol has been suggested to occur in the liver but little is known about the metabolism of this
Toll, Anders,, Bjorkhem, Ingemar, Wikvall, Kjell,, Norlin, Maria,   +3 more
core  

Cholesterol

Journal of Lipid Research, 2003
The accumulation and aggregation of the amyloid-β peptide (Aβ) in the brain are important contributing factors to Alzheimer's disease (AD). Consequently, blocking the generation of Aβ is a potentially important treatment strategy.
Robert L. Raffaï, Karl H. Weisgraber
doaj   +1 more source

The Use of Statins in Parkinson's and Alzheimer's Disease: A 2021–2025 State‐of‐the‐Art Review of Clinical and Preclinical Evidence

Pharmacology Research &Perspectives, Volume 14, Issue 3, June 2026.
ABSTRACT Statins, widely prescribed for cardiovascular prevention, have emerged as potential disease‐modifying agents in neurodegenerative disorders due to their pleiotropic effects on cholesterol metabolism, neuroinflammation, oxidative stress, and protein aggregation.
Luigi Maria Chiatto, Lucia Buccarello, Giuseppe Carota, Rocco Salvatore Calabrò, Carmela Rifici, Emanuela Esposito, Alessio Ardizzone, Giuseppe Caruso   +7 more
wiley   +1 more source

Soybean phytoestrogens reduce 27-hydroxycholesterol concentration in the liver of middle-aged female rats

, 2017
Hypercholesterolemia is associated with athero-thrombotic disease, a leading cause of mortality worldwide. Advances in both dietary and pharmacological interventions contribute to prevention and treatment of modifiable risk factors.Purified soybean ...
Verica Milošević, Miler, Marko, Filipović, Branko, Milošević, Verica, Branko Filipović, Vladimir Ajdžanović, Branka Šošić-Jurjević, Marko Miler, Lutjohann, Dieter, Snežana Janković, Ivana Jarić, Šošić-Jurjević, Branka, Janković, Snežana, Ajdžanović, Vladimir, Dieter Lutjohann, Jarić, Ivana   +15 more
core   +1 more source

Altitude‐Associated Divergence of the Gut Microbiome in Endangered Forest Musk Deer: Evidence From Integrated Metagenomics, Metabolomics, and Culturomics

Evolutionary Applications, Volume 19, Issue 6, June 2026.
ABSTRACT High‐altitude environments expose mammals and their gut symbionts to multifaceted stressors—hypoxia, cold, and intense UV radiation. Whether gut microbial communities undergo compositional restructuring in response to these stressors, and whether such restructuring carries translational value for captive conservation, remain unresolved ...
Feiyun Huang, Zexiu Zhang, Yanni Zhao, Sen Ye, Maoyuan Gan, Xuxin Li, Yele Zhang, Lei Chen, Yushuo Zhang, Lingxi Chen, Ting Wang, Jinming Huang, Xiuyue Zhang   +12 more
wiley   +1 more source

Trend of 25-hydroxycholesterol and 27-hydroxycholesterol plasma levels in patients affected by active chronic hepatitis B virus infection and inactive carriers

, 2021
Hepatitis B virus (HBV) infection is a global health problem with different immunological phases and therapeutic approaches. The serological condition of inactive carrier (IC) was recently well defined as a clinical and virological stable status, in ...
Di Perri G., Leoni V., Caccia C., Cusato J., Civra A., Poli G., D'Avolio A., Boglione L., Biasi F., Lembo D.   +9 more
core   +1 more source

Unravelling the biochemical aspects of the interaction between ticks and Leishmania using a tick cell line

Medical and Veterinary Entomology, Volume 40, Issue 2, Page 350-359, June 2026.
Leishmania infantum propagated in IDE8 tick cell line in vitro. L. infantum reduces tick cell viability and induces reactive oxygen species production. Lipidic profile of IDE8 tick cell line is altered during Leishmania infection. Abstract Leishmaniasis comprises a group of vector‐borne neglected tropical diseases caused by species of the obligatory ...
Beatriz Filgueiras Silvestre, Karoline dos Anjos Lima, Fernanda de Paula Pepino, Daniela Cosentino‐Gomes, Adivaldo Fonseca, Lesley Bell‐Sakyi, Georgia Correa Atella, Lucia H. Pinto‐da‐Silva   +7 more
wiley   +1 more source