Results 91 to 100 of about 13,032 (223)

24S-hydroxycholesterol effects on lipid metabolism genes are modeled in traumatic brain injury [PDF]

Brain Research, 2010
Membrane damage during traumatic brain injury (TBI) alters the brain homeostasis of cholesterol and other lipids. Cholesterol 24S-hydroxylase (Cyp46) is a cholesterol metabolic enzyme that is increased after TBI. Here, we systematically examined the effects of the enzymatic product of Cyp46, 24S-hydroxycholesterol, on the cholesterol regulatory genes ...
Casandra M, Cartagena, Mark P, Burns, G William, Rebeck   +2 more
openaire   +2 more sources

THE CONCISE GUIDE TO PHARMACOLOGY 2017/18:Enzymes [PDF]

, 2017
The Concise Guide to PHARMACOLOGY 2017/18 provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective pharmacology (where available), plus links to an open access knowledgebase of drug targets and ...
,, Alexander, Stephen Ph, Davies, Jamie A, Fabbro, Doriano, Faccenda, Elena, Harding, Simon D, Kelly, Eamonn, Marrion, Neil V, Pawson, Adam J, Peters, John A, Sharman, Joanna L, Southan, Christopher   +11 more
core   +15 more sources

Gut Microbiota and Extraintestinal Cancers: Mechanistic Insights and Microbiome‐Targeted Interventions

JGH Open, Volume 10, Issue 5, May 2026.
ABSTRACT The gut microbiota is a dynamic community of bacteria, viruses, fungi, and archaea that plays a pivotal role in regulating host immunity, metabolism, and systemic homeostasis. Dysbiosis, characterized by an imbalance in the microbial composition, is being increasingly recognized as a contributor not only to gastrointestinal cancers but also to
Rishi Chowdhary, Manjeet Kumar Goyal, Kirti Arora, Tanisha Sehgal, Prachi Dawer, F. N. U. Anirudh, Jeffrey Berinstein, Shrinivas Bishu, Laurie Matt‐Amaral   +8 more
wiley   +1 more source

Pharmacological inhibition of hydroxysteroid 11‐beta dehydrogenase type 1 (11‐βHSD1) after myocardial infarction preserves cardiac function in a translational mini‐pig model

British Journal of Pharmacology, Volume 183, Issue 10, Page 2236-2255, May 2026.
Abstract Background and Purpose Plasma glucocorticoids increase acutely after MI, thereafter tissue levels are amplified selectively within cells expressing 11‐ßhydroxysteroid dehydrogenase type 1 (11‐ßHSD1) that regenerates active glucocorticoids from circulating metabolites.
Sara Al Disi, Raimondo Ascione, Shazia Khan, Thomas Johnson, Eva Sammut, Vito Domenico Bruno, Daniel Baz Lopez, Carol‐Anne James, Joanna Simpson, Natalie Z. Homer, Michael Millar, Trisha Singh, Alex von Kreigsheim, Nick L. Mills, Brian R. Walker, Ruth Andrew, Scott P. Webster, Andrew Whittaker, Adrian Freeman, Gillian A. Gray   +19 more
wiley   +1 more source

CYP46A1 activation by low-dose efavirenz enhances brain cholesterol metabolism in subjects with early Alzheimer’s disease

Alzheimer’s Research & Therapy, 2022
Background Efavirenz is an anti-HIV drug, and cytochrome P450 46A1 (CYP46A1) is a CNS-specific enzyme that metabolizes cholesterol to 24-hydroxycholesterol (24HC).
Alan J. Lerner, Steven E. Arnold, Erin Maxfield, Aaron Koenig, Maria E. Toth, Brooke Fortin, Natalia Mast, Bianca A. Trombetta, John Denker, Andrew A. Pieper, Curtis Tatsuoka, Sangeetha Raghupathy, Irina A. Pikuleva   +12 more
doaj   +1 more source

Up-regulation of β-amyloidogenesis in neuron-like human cells by both 24- and 27-hydroxycholesterol: protective effect of N-acetyl-cysteine. [PDF]

, 2014
An abnormal accumulation of cholesterol oxidation products in the brain of patients with Alzheimer's disease (AD) would further link an impaired cholesterol metabolism in the pathogenesis of the disease.
Biasi, Fiorella, Gamba, Paola Francesca, Gargiulo, Simona, Giaccone, G, Guglielmotto, Michela, Iuliano, L, Leonarduzzi, Gabriella Marisa, Mauro, Alessandro, Monteleone, Debora, Poli, Giuseppe, Tamagno, Elena, Testa, Gabriella, Zerbinati, C   +12 more
core   +2 more sources

Involvement of 27-Hydroxycholesterol in Mitotane Action on Adrenocortical Carcinoma [PDF]

, 2020
Adrenocortical carcinoma (ACC) is a rare cancer with poor prognosis. Mitotane, the standard treatment for ACC, impairs adrenocortical steroid biosynthesis and cholesterol metabolism.
Basile, Vittoria, Biasi, Fiorella, Caccia, Claudio, Germano, Antonina, Iaia, Noemi, Leoni, Valerio, Poli, Giuseppe, Puglisi, Soraya, Rossin, Daniela, Saba, Laura, Terzolo, Massimo   +10 more
core   +1 more source

High cholesterol absorption efficiency interferes with bile acid metabolism and cholesterol elimination from the body

Journal of Internal Medicine, Volume 299, Issue 5, Page 628-638, May 2026.
Abstract Background Elevated low‐density lipoprotein (LDL) cholesterol causes atherosclerotic cardiovascular diseases. Variables of whole‐body cholesterol metabolism, for example, high cholesterol absorption efficiency, might also be atherogenic, whereas the role of bile acids is controversial.
Piia Simonen, Ingmar Wester, Jyri Lommi, Juha Sinisalo, Helena Gylling   +4 more
wiley   +1 more source

Reduction in Levels of 24S-Hydroxycholesterol by Statin Treatment in Patients With Alzheimer Disease [PDF]

Archives of Neurology, 2003
The statin treatment of dyslipidemia is associated with a reduced risk of development of Alzheimer disease (AD). The effect may be mediated by a reduction in cholesterol biosynthesis in the brain, by lowering levels of apolipoprotein E (apo E)-containing lipoproteins, or by pleitropic effects such as reduction in beta-amyloid production.
Gloria Lena, Vega, Myron F, Weiner, Anne M, Lipton, Klaus, Von Bergmann, Dieter, Lutjohann, Carol, Moore, Doris, Svetlik   +6 more
openaire   +2 more sources

Oxysterols and apolipoproteins in multiple sclerosis: a 5 year follow-up study[S]

Journal of Lipid Research, 2019
The purpose of this work was to investigate whether changes in oxysterol and apolipoprotein levels over 5 years are associated with disease course and disability progression in multiple sclerosis (MS).
Kelly Fellows Maxwell, Sonia Bhattacharya, Mary Lou Bodziak, Dejan Jakimovski, Jesper Hagemeier, Richard W. Browne, Bianca Weinstock-Guttman, Robert Zivadinov, Murali Ramanathan   +8 more
doaj   +1 more source