Results 101 to 110 of about 2,904,339 (217)

24-Hydroxycholesterol Moderates the Effects of Amyloid-β on Expression of HMG-CoA Reductase and ABCA1 Proteins in Mouse Astrocytes. [PDF]

Adv Biomed Res, 2023
Nazeri Z, Mohammadzadeh G, Rashidi M, Azizdoost S, Cheraghzadeh M, Kheirollah A.   +5 more
europepmc   +1 more source

Primary open-angle glaucoma: association with cholesterol 24S-hydroxylase (CYP46A1) gene polymorphism and plasma 24-hydroxycholesterol levels

, 2009
Purpose. Genetics has made significant contributions to the study of glaucoma over the past few decades. Cholesterol-24S-hydroxylase (CYP46A1) is a cholesterol-metabolizing enzyme that is especially expressed in retinal ganglion cells.
Brétillon, Lionel, Creuzot-Garcher, C, Martine, Lucy, Björkhem, Ingemar, Joffre, Corinne, Diczfalusy, Ulf, Creuzot Garcher, Catherine, Martine, L, Diczfalusy, U,, Bjoerkhem, I, Bron, A, Fourgeux, Cynthia, Bron, Alain, Acar, Niyazi, Acar, N, Fourgeux, C, Bretillon, L, Lucy, Martine, Joffre, C   +18 more
core   +1 more source

Changes in brain oxysterols at different stages of Alzheimer's disease: Their involvement in neuroinflammation

Redox Biology, 2016
Alzheimer's disease (AD) is a gradually debilitating disease that leads to dementia. The molecular mechanisms underlying AD are still not clear, and at present no reliable biomarkers are available for the early diagnosis.
Gabriella Testa, Erica Staurenghi, Chiara Zerbinati, Simona Gargiulo, Luigi Iuliano, Giorgio Giaccone, Fausto Fantò, Giuseppe Poli, Gabriella Leonarduzzi, Paola Gamba   +9 more
doaj   +1 more source

Ventriculoperitoneal Shunt Treatment Increases 7 Alpha Hy-Droxy-3-Oxo-4-Cholestenoic Acid and 24-Hydroxycholesterol Concentrations in Idiopathic Normal Pressure Hydrocephalus. [PDF]

Brain Sci, 2022
Porru E, Edström E, Arvidsson L, Elmi-Terander A, Fletcher-Sandersjöö A, Sandblom AL, Hansson M, Duell F, Björkhem I.   +8 more
europepmc   +1 more source

Characterization of soticlestat, a novel cholesterol 24-hydroxylase inhibitor, in acute and chronic neurodegeneration models

Neuroscience Research
We investigated whether soticlestat (TAK-935), a newly discovered cholesterol 24-hydroxylase (CH24H) inhibitor now in phase 3 clinical trials for Dravet and Lennox-Gastaut syndromes, has effects on neurodegeneration in both chronic and acute animal ...
Shigeo Hasegawa, Sayuri Watanabe, Shinji Fujimoto, Shinichi Kondo, Toshiya Nishi   +4 more
doaj   +1 more source

Investigation of Liver X Receptor Gene Variants and Oxysterol Dysregulation in Autism Spectrum Disorder

Children
The NR1H2 gene produces the Liver X Receptor Beta (LXRB) protein, which is crucial for brain cholesterol metabolism and neuronal development. However, its involvement in autism spectrum disorder (ASD) remains largely unexplored, aside from animal studies.
Tuğba Menteşe Babayiğit, Güvem Gümüş-Akay, Merve Çikili Uytun, Özlem Doğan, Muhittin A. Serdar, Gökçe Yağmur Efendi, Ayşe Gökçe Erman, Esra Yürümez, Didem Behice Öztop   +8 more
doaj   +1 more source

Side chain oxidized oxysterols in cerebrospinal fluid and the integrity of blood-brain and blood-cerebrospinal fluid barriers

Journal of Lipid Research, 2003
The side chain oxidized oxysterol 24S-hydroxycholesterol (24-OH-chol) is formed almost exclusively in the brain, and there is a continuous passage of this oxysterol through the circulation to the liver.
Valerio Leoni, Thomas Masterman, Pria Patel, Steve Meaney, Ulf Diczfalusy, Ingemar Björkhem   +5 more
doaj   +1 more source

Identification of regulatory oxysterols, 24(S),25-epoxycholesterol and 25-hydroxycholesterol, in cultured fibroblasts.

, 1985
Biosynthetically tritiated sterols from Chinese hamster lung (Dede) cells were fractionated by high performance liquid chromatography, and fractions were assayed for their ability to repress 3-hydroxy-3-methylglutaryl-CoA reductase in L cell cultures.
Kandutsch, A A, Gayen, A K, Spencer, T A, Saucier, S E, Phirwa, S, Taylor, F R   +5 more
core  

Dietary vitamin E supplementation on cholesterol and cholesterol oxides of pig meat and cooked ham

Brazilian Archives of Biology and Technology, 2006
Objective of this work was to evaluate the protective effect of vitamin E on the cooked ham. Ninety-six pigs (LW X L X P), forty-eight barrows and forty-eight gilts were divided in four randomized blocks.
Vera Lúcia Ferreira de Souza, Rui Sérgio S. Ferreira da Silva   +1 more
doaj   +1 more source

Modulation of lipid membrane organization of Müller Glial Cells (MGC) by 24-(S)-hydroxycholesterol (24-S-OHC) in glaucoma: Session 3: Nutrition and oxysterols biological activities

, 2016
ENO= the European Network for Oxysterol ResearchENO= the European Network for Oxysterol ResearchModulation of lipid membrane organization of Müller Glial Cells (MGC) by 24-(S)-hydroxycholesterol (24-S-OHC) in glaucoma. Session 3: Nutrition and oxysterols
Brétillon, Lionel, Martine, Lucy, Gabrielle, Pierre Henry, Gendrault, Clément, Lachot, Méline, Ferrero, Arthur, Gambert, Ségolène, Masson, Elodie A.Y., Masson, Elodie, Leclere, Laurent   +9 more
core