Results 101 to 110 of about 4,101,858 (162)

Antiproliferative effect of LXR agonists T0901317 and 22(R)-Hydroxycholesterol on multiple human cancer cell lines

, 2010
[[abstract]]Previously, we and other groups reported that liver X receptor (LXR) agonists T0901317, 22(R)-hydroxycholesterol, and 24(S) -hydroxycholesterol suppressed the proliferation of prostate and breast cancer cells.
Chuu, CP;Lin, HP
core  

Effects of 25-hydroxycholesterol and 7-ketocholesterol, inhibitors of sterol synthesis, administered orally to mice.

, 1977
When 25-hydroxycholesterol or 7-ketocholesterol was fed to mice with the diet, growth was suppressed and mature mice lost weight. The effect of the 7-ketone upon body weight was effectively counteracted by cholesterol whereas cholestanol and beta ...
Kandutsch, A A, Heiniger, H J, Chen, H W, Heiniger, H   +3 more
core   +1 more source

Relevance of 24S-hydroxycholesterol as a biomarker of optic neuropathies

, 2009
 Purpose: 24S-Hydroxycholesterol is formed by enzymatic oxidation of cholesterol via cholesterol-24S-hydroxylase (CYP46A1) activity in neurons, including retinal ganglion cells and neurons from the inner retina.
Brétillon, Lionel, Pasquis, Bruno, Martine, Lucy, Bjorkhem, Ingemar, Schnebelen, Coralie, Bron, Alain, Acar, Niyazi, Creuzot Garcher, Catherine, Fourgeux, Cynthia   +8 more
core   +1 more source

Gut microbiota-dependent 24-hydroxycholesterol metabolism contributes to capsaicin-induced amelioration of Alzheimer's disease-like pathology in mice. [PDF]

Nat Commun
Li Y, Wang H, Zhang D, Wang S, Li Z, Li J, Tai S, Tong D, Wang B, Lu D, Yuan S, Sun W, Yang B, Bai C, Wang Q, Ding J, Wang Z, Gao Y, Yu H, Cui K, Liu C, Mao J, Yao Y, Liu F, Wan Y, Yuan J, Liu X, Zheng J.   +27 more
europepmc   +1 more source

24(S)-Hydroxycholesterol protects the ex vivo rat retina from injury by elevated hydrostatic pressure [PDF]

In the central nervous system, 24(S)-hydroxycholesterol (24(S)-HC) is an oxysterol synthesized from cholesterol by cholesterol 24-hydroxylase (CYP46A1) encoded by the cyp46a1 gene.
Ishikawa, Makoto, Yoshitomi, Takeshi, Zorumski, CharlesF., Izumi, Yukitoshi   +3 more
core  

SIRT6 Mediates Sterol-Dependent Feedback Regulation of Cholesterol Biosynthetic Genes in Hepatocytes. [PDF]

Biomol Ther (Seoul)
Kim Y, Cho YE, Lim H, Park Y, Hwang S.
europepmc   +1 more source

Plasma 4β-Hydroxycholesterol Predicts Ribociclib CYP3A-Mediated Metabolism, but Not Plasma Exposure, in Patients with Primary Brain Cancer. [PDF]

Cancers (Basel)
Wickramasinghe C, Bao X, Jiang Y, Jiang J, Yue Y, Sanai N, Li J.   +6 more
europepmc   +1 more source

Reconstruction of <i>de novo</i> verazine biosynthesis in <i>Saccharomyces cerevisiae</i> and computational analysis of cholesterol-binding geometry for 22<i>R</i> hydroxylation by <i>Vc</i>CYP90B27 to dissect the cyclopamine biosynthetic pathway. [PDF]

Eng Life Sci
Li C, Yu Q, Yue F, Wang X, Zhao Y, Zhang J, Song W, Xue Z.   +7 more
europepmc   +1 more source

A CRISPR activation screen identifies CH25H as a restriction factor against influenza viruses by targeting accessible cholesterol. [PDF]

Emerg Microbes Infect
Huang J, Ma K, Ding S, Wang Y, Xiong J, Yi J, Zhang J, He Z, Huang L, Ren X, Zhou J, Chen X, Liu L, Qi W, Wang S, Liao M.   +15 more
europepmc   +1 more source

Lipid remodeling in swine spermatozoa: Innovative model for the analysis of oxysterols during capacitation. [PDF]

Vet Anim Sci
Carlo DC, Fabiola E, Ramses BP, Costanza C, Federico F, Luca V, Nicola B, Dario C, Barbara B.   +8 more
europepmc   +1 more source